Results 61 to 70 of about 273,980 (263)

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Associations of the triglyceride–glucose index and triglyceride–glucose/body mass index with all-cause mortality in Chinese centenarians

BMC Geriatrics
The triglyceride-glucose (TyG) index and triglyceride-glucose/body mass index (TyG-BMI) have been shown to be associated with cardiovascular and cerebrovascular disorders and the risk of death. The aim of this study was to explore the relationships of the TyG index and TyG-BMI with all-cause mortality among Chinese centenarians.Data from the China ...
Shiju Yan, Wenjing Dong, Yue Niu, Lingyun Song, Ping Pang, Di Sun, Yue Zhang, Wei Wang, Hongyan Hu, Xinye Jin, Jie Zhang, Qing Luo, Ding Sun, Hao Li, Zehao Zhang, Zeyu Qu, Qiao Zhu, Yujian Chen, Chaoxue Ning, Shihui Fu, Shanshan Yang, Shengshu Wang, Yao He, Bin Wang, Yali Zhao, Guoqing Yang, Xiangmei Chen, Miao Liu, Yizhi Chen   +28 more
openaire   +3 more sources

Sonogenetic Control of Engineered Probiotics for the Treatment of MASH by Modulating the Gut‐Liver Axis

Advanced Science, EarlyView.
Researchers developed an engineered probiotic encapsulated in an inulin hydrogel, enabling ultrasound‐triggered intestinal delivery of IL‐22. In MASH model mice, this system remodeled gut microbiota, strengthened the intestinal barrier and reduced portal LPS and hepatic IL‐6.
Chunya Ji, Yan Fang, Shen Zhang, Weichen Xu, Wenyun Guo, Jing Chen, Mingrui Zhu, Congjian Wen, Siming Chen, Yuli Zhu, Huixiong Xu, Haohao Yin   +11 more
wiley   +1 more source

Association of the C-reactive protein–triglyceride–glucose index with incident sarcopenia in Chinese middle-aged and older adults: A prospective cohort study

Journal of International Medical Research
Background Sarcopenia is a progressive skeletal muscle disorder associated with metabolic dysfunction and chronic inflammation. The C-reactive protein–triglyceride–glucose index integrates inflammatory and metabolic status; however, its longitudinal ...
Qin-li Xiao, Jin-feng Liu, Liang Huang, Wei Wei   +3 more
doaj   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Triglyceride-glucose index and related parameters in the diagnosis and predictive efficacy for older adults with NAFLD/MASLD: a prospective cohort study

Frontiers in Medicine
BackgroundNon-alcoholic fatty liver disease (NAFLD) affects over 25% of the global population and is associated with numerous comorbidities. Several indices, including the triglyceride-glucose (TyG) index, TyG-waist circumference (TyG-WC), TyG-body mass ...
Yuwei Chen, Xinjun Lin, Yanqiu Chen, Bingcai Wang, Chaoxiang Xu, Yaoguo Wang   +5 more
doaj   +1 more source

Triglycerides, Glucose Metabolism, and Type 2 Diabetes

International Journal of Molecular Sciences
Type 2 diabetes is a major global health burden, causing approximately 2 million deaths annually. Recent studies have revealed a strong positive correlation between elevated triglyceride levels and plasma glucose, as well as increased prevalence, incidence, and mortality of type 2 diabetes, suggesting a potential causal link.
openaire   +2 more sources

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Triglyceride-Glucose Index in the Prediction of Prediabetes

Revista Eugenio Espejo
Prediabetes is a metabolic disorder characterized by insulin resistance long before the diagnosis of type 2 diabetes mellitus (T2DM) and represents a key opportunity for intervention and prevention of T2DM. The triglyceride-glucose index (TGI) has been identified as an accessible marker of insulin resistance with potential diagnostic value.
Jorman Francisco Choez Alava, Marja Morales Baldeon, Carmen Vanessa Vaca Vera, Bertha Carolina Cruz Murillo   +3 more
openaire   +1 more source

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source