Results 41 to 50 of about 273,980 (263)

Association between Helicobacter pylori infection and MASLD: a cross-sectional study with interpretable machine learning for MASLD risk prediction

Frontiers in Nutrition
BackgroundHelicobacter pylori (HP) infection has been increasingly linked to metabolic dysfunction-associated steatotic liver disease (MASLD). However, evidence remains inconsistent, and the predictive value of HP status within integrated risk models is ...
Yue Zhang, Ruifeng Duan, Yuzhong Zhang, Lijuan Wei   +3 more
doaj   +1 more source

Evaluation of Role of Triglyceride Glucose Index as a Marker for Predicting severity of Coronary Artery Disease [PDF]

Zagazig University Medical Journal
One trustworthy substitute biomarker of insulin resistance (IR) has been found to be the triglyceride glucose (TyG) index. The development and prognosis of cardiovascular disease (CVD) have been linked to the triglyceride glucose index, according to a ...
Ibtesam El-Dosouky, Ahmed Ammar, Abdelmaaboud Abdelmaaboud, Moataz Elkot   +3 more
doaj   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Normal triglyceride levels are positively associated with plasma glucose levels and type 2 diabetes diagnosis in Chinese adults [PDF]

Exploration of Endocrine and Metabolic Diseases
Aim: Hypertriglyceridemia is linked to increased risk of diabetes diagnosis, incidence, and mortality. However, whether individuals with normal triglyceride levels (i.e., < 1.7 mmol/L) uniformly exhibit low diabetes risk remains underexplored ...
Yutang Wang, Hongying Liu, Shenzhou Ma, Tingting Qian, Hui Sun, Qun Xu, Xujuan Hou, Wenqi Hu, Guang Zhang, Maria Jelinic, Yan Fang, David Song, Guang Yang   +12 more
doaj   +1 more source

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Exploring the synergistic effects of Life’s Essential 8, insulin resistance, and CRP on cardiometabolic multimorbidity risk

Frontiers in Nutrition
BackgroundCardiometabolic multimorbidity (CMM) refers to the co-occurrence of two or more cardiometabolic diseases (CMDs), including coronary artery disease (CAD), stroke, and type 2 diabetes mellitus (T2DM), posing a substantial public health concern ...
Jiang Liu, Chuang Yang, Wenke Cheng, Daidi Li   +3 more
doaj   +1 more source

The correct formula for the triglycerides and glucose index [PDF]

European Journal of Pediatrics, 2020
Luis E, Simental-Mendía, Fernando, Guerrero-Romero   +1 more
openaire   +2 more sources

Triglycerides glucose index in Madrid university students

Nutrición Hospitalaria
Introduction: the World Health Organization has redefined the term obesity by introducing the concept of pre-obesity as a state of excess adiposity that does not compromise the body's functionality. The objective of this study is to determine the prevalence of pre-obesity in the university population, with a particular emphasis on the efficacy of the ...
Consuelo, Prado Martínez, María Dolores, Marrodán Serrano, Daysi Antonia, Navarro Despaigne   +2 more
openaire   +2 more sources