Positive Selection and Duplication of Bat TRIM Family Proteins [PDF]
Viruses, 2023 Bats have received increasing attention because of some unique biological features they possess. TRIM is a large family of proteins that participate in diverse cellular functions, such as antiviral immunity, DNA damage repair, tumor suppression, and ...
Jiazheng Xie, Bowen Tan, Yi Zhang
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Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity [PDF]
Cells, 2021 Ubiquitination is a post-translational modification that has pivotal roles in protein degradation and diversified cellular processes, and for more than two decades it has been a subject of interest in the biotech or biopharmaceutical industry. Tripartite
Utsa Bhaduri, Giuseppe Merla
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TRIM family contribute to tumorigenesis, cancer development, and drug resistance [PDF]
Experimental Hematology & Oncology, 2022 The tripartite-motif (TRIM) family represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular signaling transductions and biological processes.
Ning Huang +6 more
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TRIM family proteins: roles in proteostasis and neurodegenerative diseases [PDF]
Open Biology, 2022 Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous systems. One of the major features of NDs, such as Alzheimer's disease (AD),
Yan Zhu +4 more
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The role of TRIM family in metabolic associated fatty liver disease [PDF]
Frontiers in Endocrinology, 2023 Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated.
Jingyue Zhang +4 more
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Intricate confrontation: Research progress and application potential of TRIM family proteins in tumor immune escape [PDF]
Journal of Advanced Research, 2023 Background: Tripartite motif (TRIM) family proteins have more than 80 members and are widely found in various eukaryotic cells. Most TRIM family proteins participate in the ubiquitin-proteasome degradation system as E3-ubiquitin ligases; therefore, they ...
Junjie Gu +4 more
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Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma [PDF]
Frontiers in Oncology, 2021 BackgroundAccumulating studies have demonstrated the abnormal expressions and prognostic values of certain members of the tripartite motif (TRIM) family in diverse cancers.
Weiyu Dai +19 more
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Therapeutic potential of TRIM family proteins in gastric cancer: from signaling pathway regulation to precision targeting strategies [PDF]
Frontiers in OncologyGastric cancer (GC) is a globally prevalent malignant tumor, causing approximately 770,000 deaths in 2020, ranking fourth among all cancers. The tripartite motif (TRIM) protein family is involved in various cellular regulations and has become a key ...
Caiqing Zhao +5 more
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Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design [PDF]
Journal of Structural Biology: XTripartite motif (TRIM) proteins constitute one of the largest subfamilies of RING-type E3 ubiquitin ligases and are attractive targets for the development of novel degraders that exploit the ubiquitin–proteasome pathway.
Rezart Zhubi +4 more
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Prognostic value of tripartite motif (TRIM) family gene signature from bronchoalveolar lavage cells in idiopathic pulmonary fibrosis [PDF]
BMC Pulmonary Medicine, 2022 Background Tripartite motif (TRIM) family genes get involved in the pathogenesis and development of various biological processes; however, the prognostic value of TRIM genes for idiopathic pulmonary fibrosis (IPF) needs to be explored.
Mi Zhou +3 more
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