Results 11 to 20 of about 4,241,332 (192)

Tumor suppressor p53 cross-talks with TRIM family proteins

Genes and Diseases, 2021
p53 is a key tumor suppressor. As a transcription factor, p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor ...
Juan Liu, Cen Zhang, Xue Wang, Wenwei Hu, Zhaohui Feng   +4 more
doaj   +2 more sources

Prognostic value of tripartite motif (TRIM) family gene signature from bronchoalveolar lavage cells in idiopathic pulmonary fibrosis

BMC Pulmonary Medicine, 2022
Background Tripartite motif (TRIM) family genes get involved in the pathogenesis and development of various biological processes; however, the prognostic value of TRIM genes for idiopathic pulmonary fibrosis (IPF) needs to be explored.
Mi Zhou, Jie Ouyang, Guoqing Zhang, Xin Zhu   +3 more
doaj   +2 more sources

Emerging RNA-binding roles in the TRIM family of ubiquitin ligases

Biological Chemistry, 2019
TRIM proteins constitute a large, diverse and ancient protein family which play a key role in processes including cellular differentiation, autophagy, apoptosis, DNA repair, and tumour suppression.
Kevin Haubrich, Janosch Hennig
exaly   +2 more sources

Identification of RING E3 pseudoligases in the TRIM protein family

Nature Communications
TRIpartite Motif (TRIM) family proteins have diverse roles across a broad variety of cellular functions, which are largely presumed to depend on their ubiquitin E3 ligase activity, conferred by a RING domain.
Jane Dudley-Fraser, Diego Esposito, Katherine A. McPhie, Coltrane Morley-Williams, Tania Auchynnikava, Katrin Rittinger   +5 more
doaj   +2 more sources

TRIM family proteins: dual roles in tumor immunity

Frontiers in Cell and Developmental Biology
Tripartite motif (TRIM) proteins represent one of the largest subfamilies of E3 ubiquitin ligases and exert complex yet critical dual roles in tumor immunology by orchestrating protein ubiquitination.
Runjie Cai, Runjie Cai, Runjie Cai, Liang Chen, Liang Chen   +4 more
doaj   +2 more sources

TRIM family proteins and their emerging roles in innate immunity

Nature Reviews Immunology, 2008
The superfamily of tripartite motif-containing (TRIM) proteins is conserved throughout the metazoan kingdom and has expanded rapidly during vertebrate evolution; there are now more than 60 TRIM proteins known in humans and mice.
Anup Dey, Dong-Mi Shin, Herbert Morse
exaly   +2 more sources

Crystal structure of cytomegalovirus IE1 protein reveals targeting of TRIM family member PML via coiled-coil interactions.

PLoS Pathogens, 2014
PML nuclear bodies (PML-NBs) are enigmatic structures of the cell nucleus that act as key mediators of intrinsic immunity against viral pathogens. PML itself is a member of the E3-ligase TRIM family of proteins that regulates a variety of innate immune ...
Myriam Scherer, Stefan Klingl, Madhumati Sevvana, Victoria Otto, Eva-Maria Schilling, Joachim D Stump, Regina Müller, Nina Reuter, Heinrich Sticht, Yves A Muller, Thomas Stamminger   +10 more
doaj   +2 more sources

The Roles of TRIMs in Antiviral Innate Immune Signaling

Frontiers in Cellular and Infection Microbiology, 2021
The Tripartite motif (TRIM) protein family, which contains over 80 members in human sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family.
Zhou Shen, Zhou Shen, Lin Wei, Zhi-bo Yu, Zhi-yan Yao, Jing Cheng, Yu-tong Wang, Xiao-tian Song, Miao Li   +8 more
doaj   +1 more source

TRIMming Down Hormone-Driven Cancers: The Biological Impact of TRIM Proteins on Tumor Development, Progression and Prognostication

Cells, 2021
The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple ...
Eleonora Pauletto, Nils Eickhoff, Nuno A. Padrão, Christine Blattner, Wilbert Zwart   +4 more
doaj   +1 more source

Origin and diversification of TRIM ubiquitin ligases. [PDF]

PLoS ONE, 2012
Most proteins of the TRIM family (also known as RBCC family) are ubiquitin ligases that share a peculiar protein structure, characterized by including an N-terminal RING finger domain closely followed by one or two B-boxes.
Ignacio Marín
doaj   +1 more source