Results 31 to 40 of about 4,241,332 (192)

It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease

Frontiers in Molecular Neuroscience, 2023
The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and
Jane Dudley-Fraser, Katrin Rittinger
doaj   +1 more source

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

Cancers, 2022
Simple Summary Gliomas remain challenging tumors due to their increased heterogeneity, complex molecular profile, and infiltrative phenotype that are often associated with a dismal prognosis.
A. Giannopoulou, C. Xanthopoulos, C. Piperi, E. Kostareli   +3 more
semanticscholar   +1 more source

Enterovirus 71 induces degradation of TRIM38, a potential E3 ubiquitin ligase

Virology Journal, 2011
Background The tripartite motif (TRIM) proteins are a family of more than 70 members in human. However, only a few of them have been well studied. The TRIM proteins contain the conserved RING, B-box, coiled-coil, and SPRY domains, most of which are ...
Wang Jianwei, Xue Qinghua, Sun Zhenmin, Zhou Zhuo, Lei Xiaobo, Liu Xinlei, Hung Tao   +6 more
doaj   +1 more source

A Novel Gene Signature of Tripartite Motif Family for Predicting the Prognosis in Kidney Renal Clear Cell Carcinoma and Its Association With Immune Cell Infiltration

Frontiers in Oncology, 2022
Given the importance of tripartite motif (TRIM) proteins in diverse cellular biological processes and that their dysregulation contributes to cancer progression, we constructed a robust TRIM family signature to stratify patients with kidney renal clear ...
Di Zheng, Yunlong Zhang, Yuqi Xia, Fan Cheng   +3 more
doaj   +1 more source

Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish.

PLoS ONE, 2011
Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral
Pierre Boudinot, Lieke M van der Aa, Luc Jouneau, Louis Du Pasquier, Pierre Pontarotti, Valérie Briolat, Abdenour Benmansour, Jean-Pierre Levraud   +7 more
doaj   +1 more source

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members.

PLoS ONE, 2012
The TRIM family of proteins is distinguished by its tripartite motif (TRIM). Typically, TRIM proteins contain a RING finger domain, one or two B-box domains, a coiled-coil domain and the more variable C-terminal domains.
Jessica L Bell, Alena Malyukova, Jessica K Holien, Jessica Koach, Michael W Parker, Maria Kavallaris, Glenn M Marshall, Belamy B Cheung   +7 more
doaj   +1 more source

The role of TRIM family proteins in the regulation of cancer stem cell self‐renewal

Stem Cells, 2019
The tripartite‐motif (TRIM) family of proteins represents one of the largest classes of putative single protein RING‐finger E3 ubiquitin ligases. The members of this family are characterized by an N‐terminal TRIM motif containing one RING‐finger domain ...
A. Jaworska, N. Wlodarczyk, A. Mackiewicz, Patrycja Czerwińska   +3 more
semanticscholar   +1 more source

An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer

Human Genomics
Most TRIM family members characterized by the E3-ubiquitin ligases, participate in ubiquitination and tumorigenesis. While there is a dearth of a comprehensive investigation for the entire family in gastric cancer (GC).
Yixin Ding, Yangyang Lu, Jing Guo, Shuming Chen, Xiaoxi Han, Shibo Wang, Mengqi Zhang, Rui Wang, Jialin Song, Kongjia Wang, Wensheng Qiu, Weiwei Qi   +11 more
semanticscholar   +1 more source

Exploring the Mechanisms, Biomarkers, and Therapeutic Targets of TRIM Family in Gastrointestinal Cancer

Drug Design, Development and Therapy
Gastrointestinal region (GI) cancers are closely linked to the ubiquitination system, with the E3 ubiquitin ligase playing a crucial role by targeting various substrates.
Chunyan Weng, Rijuan Jin, Xiaoliang Jin, Zimei Yang, Chenghai He, Qiu-Lu Zhang, Jingli Xu, Bin Lv   +7 more
semanticscholar   +1 more source

Cellular Function of TRIM E3 Ubiquitin Ligases in Health and Disease

Cells, 2022
The field of the Tripartite Motif (TRIM) family has progressively attracted increasing interest during the last two decades [...]
Germana Meroni, Solange Desagher
doaj   +1 more source