Results 21 to 30 of about 4,241,332 (192)

Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers

Cells, 2022
Increasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known
Kotaro Azuma, Satoshi Inoue
doaj   +1 more source

Comprehensive analysis of the prognostic and immunological signature of eight Tripartitemotif (TRIM) family molecules in human gliomas

Aging, 2023
Background: TRIM family molecules have been identified as being involved in the tumor progression of various cancer types. Increasingly, experimental evidence indicates that some of TRIM family molecules are implicated in glioma tumorigenesis.
Jiajie Lu, Kairong Liang, Renheng Zou, Yuecheng Peng, Haojian Wang, Rihong Huang, Zhao-Cheng Zeng, Zejiao Feng, Yongyan Fan, Shizhen Zhang, Yun-xiang Ji, Xiao Pang, Yezhong Wang, Hongri Zhang, Zhaotao Wang   +14 more
semanticscholar   +1 more source

TRIM proteins in hepatocellular carcinoma

Journal of Biomedical Science, 2022
The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain.
Kan Lu, Yonglong Pan, Zhao Huang, Huifang Liang, Ze-yang Ding, Bixiang Zhang   +5 more
doaj   +1 more source

E3 ubiquitin ligase-dependent regulatory mechanism of TRIM family in carcinogenesis

Cancer Insight, 2023
Tripartite motif-containing (TRIM) proteins consist of over 80 proteins, the majority of which exhibit E3 ubiquitin ligase activity. E3 ligases have a critical role in various cellular processes by specifically recognizing and ubiquitinating substrate ...
Gui Zhang, Yunfang Zhang, Luxuan Chen, Langxia Liu, Xuejuan Gao   +4 more
semanticscholar   +1 more source

Human TRIM gene expression in response to interferons. [PDF]

PLoS ONE, 2009
BackgroundTripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of ...
Laetitia Carthagena, Anna Bergamaschi, Joseph M Luna, Annie David, Pradeep D Uchil, Florence Margottin-Goguet, Walther Mothes, Uriel Hazan, Catherine Transy, Gianfranco Pancino, Sébastien Nisole   +10 more
doaj   +1 more source

Bioinformatics analysis of immune infiltrates and tripartite motif (TRIM) family genes in hepatocellular carcinoma

Journal of Gastrointestinal Oncology, 2022
Background The tripartite motif (TRIM) family are important members of the Gene-finger-containing E3 ubiquitin-conjugating enzyme and are involved in the progression of hepatocellular carcinoma (HCC).
Jun Cao, B. Su, R. Peng, Hao Tang, D. Tu, Yuhong Tang, Jie Zhou, Guoqing Jiang, S. Jin, Qian Wang, Ao-qing Wang, Ren-jie Liu, Qiangwei Deng, Chi Zhang, Dousheng Bai   +14 more
semanticscholar   +1 more source

Ubiquitination-coupled liquid phase separation regulates the accumulation of the TRIM family of ubiquitin ligases into cytoplasmic bodies

PLoS ONE, 2022
Many members of the tripartite motif (TRIM) family of ubiquitin ligases localize in spherical, membrane-free structures collectively referred to as cytoplasmic bodies (CBs) in a concentration-dependent manner.
Takafumi Tozawa, K. Matsunaga, T. Izumi, N. Shigehisa, Takamasa Uekita, M. Taoka, T. Ichimura   +6 more
semanticscholar   +1 more source

Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates

Nature Communications, 2023
TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular antibody receptor TRIM21, which is responsible for mediating targeted protein degradation during Trim-Away.
Leo Kiss, Tyler Rhinesmith, Jakub Luptak, Claire F. Dickson, Jonas Weidenhausen, Shannon Smyly, Ji-Chun Yang, Sarah L. Maslen, Irmgard Sinning, David Neuhaus, Dean Clift, Leo C. James   +11 more
doaj   +1 more source

Comprehensive Analysis of TRIM Family Genes in Hepatitis Virus B-Related Hepatoma Carcinoma

Frontiers in Genetics, 2022
Background: As significant components of E3 ligases, the tripartite motif (TRIM) proteins participate in various biological processes and facilitate the development of several diseases. Nevertheless, the correlations of TIRMs with hepatitis B virus (HBV)-
Wei Hu, Dongsheng Liu, Renjie Li, H. Qian, W. Qiu, Qing-wang Ye, Fanyun Kong   +6 more
semanticscholar   +1 more source

Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

BMC Evolutionary Biology, 2008
Background The TRIM family is composed of multi-domain proteins that display the Tripartite Motif (RING, B-box and Coiled-coil) that can be associated with a C-terminal domain.
Fontanella Bianca, Cairo Stefano, Sardiello Marco, Ballabio Andrea, Meroni Germana   +4 more
doaj   +1 more source