Results 1 to 10 of about 4,241,233 (93)
Journal of Advanced Research, 2023 Background: Tripartite motif (TRIM) family proteins have more than 80 members and are widely found in various eukaryotic cells. Most TRIM family proteins participate in the ubiquitin-proteasome degradation system as E3-ubiquitin ligases; therefore, they ...
Junjie Gu +4 more
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Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma
Frontiers in Oncology, 2021 BackgroundAccumulating studies have demonstrated the abnormal expressions and prognostic values of certain members of the tripartite motif (TRIM) family in diverse cancers.
Weiyu Dai +19 more
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Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity
Cells, 2021 Ubiquitination is a post-translational modification that has pivotal roles in protein degradation and diversified cellular processes, and for more than two decades it has been a subject of interest in the biotech or biopharmaceutical industry. Tripartite
Utsa Bhaduri, Giuseppe Merla
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The role of TRIM family in metabolic associated fatty liver disease
Frontiers in Endocrinology, 2023 Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated.
Jingyue Zhang +4 more
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Frontiers in Cell and Developmental BiologyIntervertebral disc degeneration (IVDD) is a leading cause of chronic back pain, contributing significantly to reduced quality of life and global public health burdens.
Shangze Li +4 more
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TRIM family contribute to tumorigenesis, cancer development, and drug resistance
Experimental Hematology & Oncology, 2022 The tripartite-motif (TRIM) family represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular signaling transductions and biological processes.
Ning Huang +6 more
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Positive Selection and Duplication of Bat TRIM Family Proteins
Viruses, 2023 Bats have received increasing attention because of some unique biological features they possess. TRIM is a large family of proteins that participate in diverse cellular functions, such as antiviral immunity, DNA damage repair, tumor suppression, and ...
Jiazheng Xie, Bowen Tan, Yi Zhang
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TRIM family proteins: roles in proteostasis and neurodegenerative diseases
Open Biology, 2022 Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous systems. One of the major features of NDs, such as Alzheimer's disease (AD),
Yan Zhu +4 more
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Cancers, 2023 Simple Summary The p53 protein is an important tumor suppressor, and TP53 mutations are frequently low survival rates of cancer patients. Mutations in TP53 lead in loss of tumor suppressing functions which result in the development of tumors.
Nami Mccarty
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The roles and targeting options of TRIM family proteins in tumor
Frontiers in Pharmacology, 2022 Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are critically implicated in the occurrence and development of tumors.
Lufeng Zheng +2 more
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