Results 21 to 30 of about 209,912 (265)
The Roles of TRIMs in Antiviral Innate Immune Signaling
Frontiers in Cellular and Infection Microbiology, 2021 The Tripartite motif (TRIM) protein family, which contains over 80 members in human sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family.
Zhou Shen +8 more
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Cells, 2021 The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple ...
Eleonora Pauletto +4 more
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The TRIM family protein KAP1inhibits HIV [PDF]
Cell Host & Microbe, 2011 The integration of viral cDNA into the host genome is a critical step in the life cycle of HIV-1. This step is catalyzed by integrase (IN), a viral enzyme that is positively regulated by acetylation via the cellular histone acetyl transferase (HAT) p300.
Allouch +4 more
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Origin and diversification of TRIM ubiquitin ligases. [PDF]
PLoS ONE, 2012 Most proteins of the TRIM family (also known as RBCC family) are ubiquitin ligases that share a peculiar protein structure, characterized by including an N-terminal RING finger domain closely followed by one or two B-boxes.
Ignacio Marín
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Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers
Cells, 2022 Increasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known
Kotaro Azuma, Satoshi Inoue
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TRIM proteins in hepatocellular carcinoma
Journal of Biomedical Science, 2022 The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain.
Kan Lu +5 more
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Identification of key genes and pathways for melanoma in the TRIM family. [PDF]
Cancer Med, 2020 AbstractCertain members of the TRIM family have been shown to have abnormal expression and prognostic value in cancer. However, in the development and progression of melanoma, the role of different TRIM family members remains unknown. To address this issue, this study used the Oncomine, UCSC, Human Protein Atlas, DAVID, and GEPIA databases to study the
Xia Y, Zhao J, Yang C.
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Structural insights into the TRIM family of ubiquitin E3 ligases. [PDF]
Cell Res, 2014 Li Y +12 more
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Human TRIM gene expression in response to interferons. [PDF]
PLoS ONE, 2009 BackgroundTripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of ...
Laetitia Carthagena +10 more
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Positive selection of the TRIM family regulatory region in primate genomes. [PDF]
Proc Biol Sci, 2016 Viral selection pressure has acted on restriction factors that play an important role in the innate immune system by inhibiting the replication of viruses during primate evolution. Tripartite motif-containing (TRIM) family members are some of these restriction factors.
He DD +5 more
europepmc +4 more sources