TRIM family proteins: roles in proteostasis and neurodegenerative diseases [PDF]
Open Biology, 2022 Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous systems. One of the major features of NDs, such as Alzheimer's disease (AD),
Yan Zhu +4 more
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Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity [PDF]
Cells, 2021 Ubiquitination is a post-translational modification that has pivotal roles in protein degradation and diversified cellular processes, and for more than two decades it has been a subject of interest in the biotech or biopharmaceutical industry. Tripartite
Utsa Bhaduri, Giuseppe Merla
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Positive Selection and Duplication of Bat TRIM Family Proteins [PDF]
Viruses, 2023 Bats have received increasing attention because of some unique biological features they possess. TRIM is a large family of proteins that participate in diverse cellular functions, such as antiviral immunity, DNA damage repair, tumor suppression, and ...
Jiazheng Xie, Bowen Tan, Yi Zhang
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Tumor suppressor p53 cross-talks with TRIM family proteins [PDF]
Genes and Diseases, 2021 p53 is a key tumor suppressor. As a transcription factor, p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor ...
Juan Liu +4 more
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Intricate confrontation: Research progress and application potential of TRIM family proteins in tumor immune escape [PDF]
Journal of Advanced Research, 2023 Background: Tripartite motif (TRIM) family proteins have more than 80 members and are widely found in various eukaryotic cells. Most TRIM family proteins participate in the ubiquitin-proteasome degradation system as E3-ubiquitin ligases; therefore, they ...
Junjie Gu +4 more
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The roles and targeting options of TRIM family proteins in tumor [PDF]
Frontiers in Pharmacology, 2022 Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are critically implicated in the occurrence and development of tumors.
Yuxin Zhang +5 more
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The antiviral spectra of TRIM5α orthologues and human TRIM family proteins against lentiviral production. [PDF]
PLoS ONE, 2011 BackgroundRhesus monkey TRIM5α (TRIM5αrh) recognizes the incoming HIV-1 core through its C-terminal B30.2(PRYSPRY) domain and promotes its premature disassembly or degradation before reverse transcription.
Seiga Ohmine +5 more
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Therapeutic potential of TRIM family proteins in gastric cancer: from signaling pathway regulation to precision targeting strategies [PDF]
Frontiers in OncologyGastric cancer (GC) is a globally prevalent malignant tumor, causing approximately 770,000 deaths in 2020, ranking fourth among all cancers. The tripartite motif (TRIM) protein family is involved in various cellular regulations and has become a key ...
Caiqing Zhao +5 more
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Exploring Potential Germline-Associated Roles of the TRIM-NHL Protein NHL-2 Through RNAi Screening [PDF]
G3: Genes, Genomes, Genetics, 2017 TRIM-NHL proteins are highly conserved regulators of developmental pathways in vertebrates and invertebrates. The TRIM-NHL family member NHL-2 in Caenorhabditis elegans functions as a miRNA cofactor to regulate developmental timing.
Gregory M. Davis +3 more
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Unveiling the multifaceted functions of TRIM proteins in glioma pathogenesis [PDF]
Translational OncologyGliomas, the most prevalent malignant primary brain tumors in adults, represent a heterogeneous group of neoplasms characterized by poor prognosis and limited therapeutic options, particularly in high-grade cases.
Wenjie Wu +3 more
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