Results 21 to 30 of about 39,322 (281)
The TRIM family protein KAP1inhibits HIV [PDF]
Cell Host & Microbe, 2011 The integration of viral cDNA into the host genome is a critical step in the life cycle of HIV-1. This step is catalyzed by integrase (IN), a viral enzyme that is positively regulated by acetylation via the cellular histone acetyl transferase (HAT) p300.
Allouch +4 more
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Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers
Cells, 2022 Increasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known
Kotaro Azuma, Satoshi Inoue
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TRIM proteins in hepatocellular carcinoma
Journal of Biomedical Science, 2022 The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain.
Kan Lu +5 more
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Origin and diversification of TRIM ubiquitin ligases. [PDF]
PLoS ONE, 2012 Most proteins of the TRIM family (also known as RBCC family) are ubiquitin ligases that share a peculiar protein structure, characterized by including an N-terminal RING finger domain closely followed by one or two B-boxes.
Ignacio Marín
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Human TRIM gene expression in response to interferons. [PDF]
PLoS ONE, 2009 BackgroundTripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of ...
Laetitia Carthagena +10 more
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TRIM Family Proteins in Intracellular Vesicle Trafficking [PDF]
Biophysical Journal, 2017 The tripartite motif (TRIM) family of over 75 different proteins serves regulative roles in many critical aspects of health and disease including wound healing, immunity, secretion and cancer. Our laboratory has previously shown that MG53 (TRIM72) played an essential role in cell membrane repair via trafficking of intracellular vesicles to the injury ...
Kristyn Gumpper +7 more
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TRIM family proteins and their emerging roles in innate immunity. [PDF]
Nat Rev Immunol, 2008 The superfamily of tripartite motif-containing (TRIM) proteins is conserved throughout the metazoan kingdom and has expanded rapidly during vertebrate evolution; there are now more than 60 TRIM proteins known in humans and mice. Many TRIM proteins are induced by type I and type II interferons, which are crucial for many aspects of resistance to ...
Ozato K, Shin DM, Chang TH, Morse HC.
europepmc +4 more sources
Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins [PDF]
Frontiers in Cell and Developmental Biology, 2020 Protein quality control (PQC) is pivotal for eukaryotic cells to eliminate misfolded proteins and maintain cellular homeostasis. A decreased or increased capacity of PQC is associated with various diseases, e.g., neurodegenerative diseases and cancers. Recently, increasing evidences have suggested that tripartite motif-containing family proteins (TRIMs)
Litian Zhang +7 more
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Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. [PDF]
EMBO Mol Med, 2011 The innate immune system recognizes microbial components through pattern-recognition receptors (PRRs), including membrane-bound Toll-like receptors and cytosolic receptors such as RIG-I-like receptors and deoxyribonucleic acid (DNA) sensors. These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines ...
Kawai T, Akira S.
europepmc +3 more sources
The role of TRIM family in metabolic associated fatty liver disease
Frontiers in Endocrinology, 2023 Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated.
Jingyue Zhang +4 more
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