Regulation of Mitochondria-Derived Immune Activation by 'Antiviral' TRIM Proteins. [PDF]
VirusesMitochondria are key orchestrators of antiviral responses that serve as platforms for the assembly and activation of innate immune-signaling complexes. In response to viral infection, mitochondria can be triggered to release immune-stimulatory molecules ...
Oh S, Mandell MA.
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A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases [PDF]
VirusesTripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity.
Adam Hage, Mikhaila Janes, Sonja M. Best
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TRIM Proteins and Their Roles in Antiviral Host Defenses. [PDF]
Annu Rev Virol, 2018 Tripartite motif (TRIM) proteins are a versatile family of ubiquitin E3 ligases involved in a multitude of cellular processes. Studies in recent years have demonstrated that many TRIM proteins play central roles in the host defense against viral ...
van Gent M, Sparrer KMJ, Gack MU.
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TRIM Proteins and Their Roles in the Influenza Virus Life Cycle. [PDF]
Microorganisms, 2020 The ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects ...
Lee HR, Lee MK, Kim CW, Kim M.
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Current Biology, 2019 Vunjak and Versteeg introduce the TRIM family of post-translational modifiers and the roles of these proteins in viral restriction, immune signaling and autophagy.
Milica Vunjak, Gijs A. Versteeg
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Targeting Chemoresistant Tumors: Could TRIM Proteins-p53 Axis Be a Possible Answer? [PDF]
Int J Mol Sci, 2019 Chemosensitivity is a crucial feature for all tumours so that they can be successfully treated, but the huge heterogeneity of these diseases, to be intended both inter- and intra-tumour, makes it a hard-to-win battle.
Valletti A +4 more
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Beyond Tumors: The Pivotal Role of TRIM Proteins in Chronic Non-Tumor Lung Diseases [PDF]
Journal of Inflammation ResearchXiangfei Huang, Wen Yu, Aiping Wei, Xifeng Wang, Shibiao Chen Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of ChinaCorrespondence: Shibiao Chen, Department of Anesthesiology, The ...
Huang X, Yu W, Wei A, Wang X, Chen S
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Therapeutic potential of TRIM family proteins in gastric cancer: from signaling pathway regulation to precision targeting strategies [PDF]
Frontiers in OncologyGastric cancer (GC) is a globally prevalent malignant tumor, causing approximately 770,000 deaths in 2020, ranking fourth among all cancers. The tripartite motif (TRIM) protein family is involved in various cellular regulations and has become a key ...
Caiqing Zhao +5 more
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Ubiquitination, Biotech Startups, and the Future of TRIM Family Proteins: A TRIM-Endous Opportunity [PDF]
Cells, 2021 Ubiquitination is a post-translational modification that has pivotal roles in protein degradation and diversified cellular processes, and for more than two decades it has been a subject of interest in the biotech or biopharmaceutical industry. Tripartite
Utsa Bhaduri, Giuseppe Merla
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TRIM family proteins: roles in proteostasis and neurodegenerative diseases
Open Biology, 2022 Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous systems. One of the major features of NDs, such as Alzheimer's disease (AD),
Yan Zhu +4 more
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