Results 111 to 120 of about 499 (147)

Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings. [PDF]

Drug Des Devel Ther, 2018
Kuca K, Karasova JZ, Soukup O, Kassa J, Novotna E, Sepsova V, Horova A, Pejchal J, Hrabinova M, Vodakova E, Jun D, Nepovimova E, Valis M, Musilek K.   +13 more
europepmc   +1 more source

Towards Completion of the "Periodic Table" of Di-2-Pyridyl Ketoxime. [PDF]

Molecules
Stamou C, Polyzou CD, Lada ZG, Konidaris KF, Perlepes SP.   +4 more
europepmc   +1 more source

Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate (DFP): Comparison with the established oximes pralidoxime, obidoxime, trimedoxime, methoxime and HI-6

, 2018
Hasan, M. Y., Lorke, D. E., Nurulain, S. M., Kuca, K., Schmitt, A., Petmianu, G. A.   +5 more
openaire   +1 more source

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Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma

Journal of Applied Toxicology, 2013
ABSTRACTK027 [1‐(4‐hydroxyiminomethylpyridinium)‐3‐(4‐carbamoylpyridinium)–propane dibromide] is a promising new reactivator of organophosphate‐ or organophosphonate‐inhibited acetylcholinesterase (AChE) with low acute toxicity and broad spectrum efficacy. The aim of the present study was to compare the pharmacokinetics of both compounds.
J. Karasova, J. Chládek, M. Hroch, Fusek Josef, D. Hnidkova, K. Kuča   +5 more
semanticscholar   +3 more sources

Civilian Adult Self Injections of Atropine – Trimedoxime (TMB4) Auto-Injectors

Clinical Toxicology, 2006
The clinical effects of self injections of atropine-trimedoxime auto-injectors distributed to the civilian population as a field antidote for nerve agent attack were assessed.Data on self injections by adults (> or = 18 years) were collected from the Israel Poison Information Center and a hospital Emergency Department's records during a 2-year period ...
Y. Bentur, Ido Layish, A. Krivoy, M. Berkovitch, E. Rotman, Shmuel Bar Haim, Y. Yehezkelli, E. Kozer   +7 more
semanticscholar   +3 more sources

A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats [PDF]

Toxicology Mechanisms and Methods, 2017
The ability of two newly developed bispyridinium oximes (K920, K923) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the oxime K203 and trimedoxime using a functional observational battery (FOB). The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (130 μg/
J. Kassa, J. Misík, J. Hatlapatková, J. Zdarova Karasova   +3 more
semanticscholar   +4 more sources

Partition of bispyridinium oximes (trimedoxime and K074) administered in therapeutic doses into different parts of the rat brain.

Journal of Pharmaceutical and Biomedical Analysis, 2011
The penetration of acetylcholinesterase reactivators (oximes) into the central nervous system is typically restricted by the blood-brain barrier. Although oximes are highly hydrophilic compounds, some contradictory results confirming permeation into the brain exist.
J. Karasova, F. Zemek, J. Bajgar, M. Vašatová, P. Procházka, L. Novotný, K. Kuča   +6 more
semanticscholar   +3 more sources

A Comparison of the Reactivating and Therapeutic Efficacy of Two Newly Developed Oximes (K727 and K733) with Oxime K203 and Trimedoxime in Tabun‐Poisoned Rats and Mice [PDF]

Basic & Clinical Pharmacology & Toxicology, 2015
AbstractThe reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun‐poisoned rats and mice. The oxime‐induced reactivation of tabun‐inhibited acetylcholinesterase was measured in diaphragm and brain of tabun‐poisoned rats.
J. Kassa, V. Sepsova, M. Tůmová, A. Horova, K. Musílek   +4 more
semanticscholar   +3 more sources

Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI-6

Toxicology Mechanisms and Methods, 2009
Introduction. The new K-oximes, K-27 [1-(4-hydroxyimino-methylpyridinium)-4-(4-carbamoylpyridinium) propane dibromide] and K-48 [1-(4-hydroxyimino-methylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide], show good in vitro efficacy in protecting acetylcholinesterase from inhibition by different organophosphorus compounds (OPCs), including nerve ...
D. Lorke, M. Hasan, S. Nurulain, K. Kuča, A. Schmitt, G. Petroianu   +5 more
semanticscholar   +4 more sources

A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat

Archives of Toxicology, 2007
This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The effectiveness of trimedoxime, obidoxime, pralidoxime and HI-6, given with atropine and diazepam, was tested in the treatment of poisoning with 2 LD50 of the insecticides.
M. Jokanović, M. Maksimović
semanticscholar   +3 more sources