Results 91 to 100 of about 177 (110)
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Toxicology Mechanisms and Methods, 2013
The potency of two newly developed oximes (K361 and K378) to reactivate tabun-inhibited cholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods. The study determining percentage of reactivation of tabun-inhibited diaphragm cholinesterase in poisoned rats showed that the reactivating ...
Jiri, Kassa +4 more
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The potency of two newly developed oximes (K361 and K378) to reactivate tabun-inhibited cholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods. The study determining percentage of reactivation of tabun-inhibited diaphragm cholinesterase in poisoned rats showed that the reactivating ...
Jiri, Kassa +4 more
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Drug and Chemical Toxicology, 2011
The ability of two combinations of oximes (HI-6+trimedoxime, HI-6+K203) to reduce soman-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of the oxime HI-6 alone, using a functional observational battery. Soman-induced neurotoxicity and the neuroprotective effects of HI-6 alone and HI-6 combined with trimedoxime
Jiri, Kassa +2 more
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The ability of two combinations of oximes (HI-6+trimedoxime, HI-6+K203) to reduce soman-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of the oxime HI-6 alone, using a functional observational battery. Soman-induced neurotoxicity and the neuroprotective effects of HI-6 alone and HI-6 combined with trimedoxime
Jiri, Kassa +2 more
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Toxicology Mechanisms and Methods, 2012
The potency of three newly developed bispyridinium compounds (K454, K456, K458) to reactivate tabun-inhibited acetylcholinesterase and reduce tabun-induced lethal toxic effects was compared with the oxime K203 and trimedoxime using in vivo methods.
Jiri, Kassa +3 more
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The potency of three newly developed bispyridinium compounds (K454, K456, K458) to reactivate tabun-inhibited acetylcholinesterase and reduce tabun-induced lethal toxic effects was compared with the oxime K203 and trimedoxime using in vivo methods.
Jiri, Kassa +3 more
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Toxicology Mechanisms and Methods, 2010
The neuroprotective effects of newly-developed oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) in combination with atropine in rats poisoned with soman were studied. The soman-induced neurotoxicity was monitored using a functional observational battery at 24 h following soman challenge.
Jiri, Kassa +4 more
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The neuroprotective effects of newly-developed oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) in combination with atropine in rats poisoned with soman were studied. The soman-induced neurotoxicity was monitored using a functional observational battery at 24 h following soman challenge.
Jiri, Kassa +4 more
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HPLC method for determination of oximes HI-6 and trimedoxime in plasma
1995A high-performance liquid chromatographic (HPLC) assay was developed to determine HI-6 and trimedoxime concentrations in small volumes of plasma. The HPLC system comprised a high-pressure pump (model 2150), a multiwavelenght detector (model 2140) set at 284 nm and 295 nm for detection of trimedoxime and HI-6, respectively, and a sample injector ...
Milić, B +2 more
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Drug and Chemical Toxicology, 2008
The potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, trimedoxime, and HI-6) to counteract tabun or cyclosarin-induced acute toxic effects was studied in mice. The therapeutic efficacy of trimedoxime and both newly developed oximes (K074, K075) was significantly higher than the potency of obidoxime and the oxime HI-6 ...
Jirí, Kassa, Vojtech, Humlicek
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The potency of newly developed oximes (K074, K075) and commonly used oximes (obidoxime, trimedoxime, and HI-6) to counteract tabun or cyclosarin-induced acute toxic effects was studied in mice. The therapeutic efficacy of trimedoxime and both newly developed oximes (K074, K075) was significantly higher than the potency of obidoxime and the oxime HI-6 ...
Jirí, Kassa, Vojtech, Humlicek
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Bratislavske lekarske listy, 2011
The present experiment is based on biochemical assessment of nerve agent soman intoxication and atropine, respectively atropine and HI-6, trimedoxime or K203 treatment in rats.Nerve agents are toxic substances irreversibly inhibiting enzyme acetylcholinesterase (AChE).
M, Pohanka, J, Pikula, K, Kuca, J, Kassa
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The present experiment is based on biochemical assessment of nerve agent soman intoxication and atropine, respectively atropine and HI-6, trimedoxime or K203 treatment in rats.Nerve agents are toxic substances irreversibly inhibiting enzyme acetylcholinesterase (AChE).
M, Pohanka, J, Pikula, K, Kuca, J, Kassa
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2006
IV Kongres farmaceuta Srbije sa međunarodnim učešćem, 29. novembar – 2.
Stefanović, D. +5 more
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IV Kongres farmaceuta Srbije sa međunarodnim učešćem, 29. novembar – 2.
Stefanović, D. +5 more
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ANTIMUSCARINIC PROPERTIES OF TRIMEDOXIME AND OBIDOXIME
1977Milorad Terzic, Milenko Milošević
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