Results 91 to 100 of about 271 (121)
ANTIMUSCARINIC PROPERTIES OF TRIMEDOXIME AND OBIDOXIME
, 1977 Milorad Terzic, Milenko Milošević
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Trimedoxime and HI‐6: Kinetic Comparison after Intravenous Administration to Mice
Basic and Clinical Pharmacology and Toxicology, 1996 Abstract: The intravenous pharmacokinetics of the oximes HI‐6 (pyridinium‐1‐(((4‐carbamoi 1‐pyridinio)metoxy)rnethyl)‐2‐(hydroxyiminomethyl)dichloride monohydrate), (132.54 μmol/kg) and trimedoxime (1,1′‐(1,3′‐propanedyl)bis((4‐hydroxyimino) methyl)‐pyridinium dibromide), (55,98 μmol/kg) in mice was investigated. The concentrations of oximes in plasma
B, Milic, M, Maksimovic, M, Nedelijkovic
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Civilian Adult Self Injections of Atropine – Trimedoxime (TMB4) Auto-Injectors
Clinical Toxicology, 2006The clinical effects of self injections of atropine-trimedoxime auto-injectors distributed to the civilian population as a field antidote for nerve agent attack were assessed.Data on self injections by adults (> or = 18 years) were collected from the Israel Poison Information Center and a hospital Emergency Department's records during a 2-year period ...
Matitiahu Berkovitch +2 more
exaly +3 more sources
Archives of Toxicology, 1995
This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The effectiveness of trimedoxime, obidoxime, pralidoxime and HI-6, given with atropine and diazepam, was tested in the treatment of poisoning with 2 LD50 of the insecticides.
Milan Jokanovic
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This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The effectiveness of trimedoxime, obidoxime, pralidoxime and HI-6, given with atropine and diazepam, was tested in the treatment of poisoning with 2 LD50 of the insecticides.
Milan Jokanovic
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Journal of Pharmaceutical and Biomedical Analysis, 2011
The penetration of acetylcholinesterase reactivators (oximes) into the central nervous system is typically restricted by the blood-brain barrier. Although oximes are highly hydrophilic compounds, some contradictory results confirming permeation into the brain exist.
Kamil Kuca +2 more
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The penetration of acetylcholinesterase reactivators (oximes) into the central nervous system is typically restricted by the blood-brain barrier. Although oximes are highly hydrophilic compounds, some contradictory results confirming permeation into the brain exist.
Kamil Kuca +2 more
exaly +3 more sources
Chemico-Biological Interactions, 2010
Up to now, intensive attempts to synthesize a universal reactivator able to reactivate cholinesterases inhibited by all types of nerve agents/organophosphates were not successful. Therefore, another approach using a combination of two reactivators differently reactivating enzyme was used: in rats poisoned with tabun and treated with combination of ...
Josef Fusek +2 more
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Up to now, intensive attempts to synthesize a universal reactivator able to reactivate cholinesterases inhibited by all types of nerve agents/organophosphates were not successful. Therefore, another approach using a combination of two reactivators differently reactivating enzyme was used: in rats poisoned with tabun and treated with combination of ...
Josef Fusek +2 more
exaly +3 more sources
Experimental and Toxicologic Pathology, 2001
In this study we have examined the effects of atropine, trimedoxime (TMB-4) and methylprednisolone (MP) on the development of organophosphate-induced delayed polyneuropathy (OPIDP) in the hen. The birds were treated with standard neuropathic dose of diisopropylfluorophosphate (DFP) (1.1 mg/kg, sc), which produced OPIDP that could be graded as 5 on the ...
M, Jokanović +5 more
openaire +2 more sources
In this study we have examined the effects of atropine, trimedoxime (TMB-4) and methylprednisolone (MP) on the development of organophosphate-induced delayed polyneuropathy (OPIDP) in the hen. The birds were treated with standard neuropathic dose of diisopropylfluorophosphate (DFP) (1.1 mg/kg, sc), which produced OPIDP that could be graded as 5 on the ...
M, Jokanović +5 more
openaire +2 more sources
Toxicology, 2008
The potency of newly developed monoxime bispyridinium compounds (K156, K203) in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.
Kamil Kuca +2 more
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The potency of newly developed monoxime bispyridinium compounds (K156, K203) in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.
Kamil Kuca +2 more
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Neurophysiology, 1988
The reactivating and cholinolytic action of trimedoxime bromide was evaluated during experiments on rat soleus and diaphragm muscles accoridng to the amplitude and time course of miniature end-plate potentials and currents (MEPP and MEPC respectively). This agent reactivates acetylcholinesterase (AChE) phosphorylation.
R A Giniatullin
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The reactivating and cholinolytic action of trimedoxime bromide was evaluated during experiments on rat soleus and diaphragm muscles accoridng to the amplitude and time course of miniature end-plate potentials and currents (MEPP and MEPC respectively). This agent reactivates acetylcholinesterase (AChE) phosphorylation.
R A Giniatullin
exaly +2 more sources