Results 71 to 80 of about 177 (110)
The Effect of Trimedoxime on Acetylcholinesterase and on the Cholinergic System of the Rat Bladder [PDF]
Journal of Applied Biomedicine, 2010 Summary Trimedoxime is a bisquaternary oxime that is widely used in the treatment of organophosphorous poisoning caused by tabun and paraoxon. We tested its affinity to acetylcholinesterase (AChE), its mechanism of interaction and effect on the cholinergic system of the rat bladder.
Ondrej Soukup, Josef Fusek, Kamil Kuča
exaly +2 more sources
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Pediatric Poisoning From Trimedoxime (TMB4) and Atropine Automatic Injectors
Journal of Pediatrics, 2005To describe the effects of combined trimedoxime (TMB4) and atropine poisoning from automatic injectors (AI) in children.Data was collected from two sources: calls to the Israel Poison Information Center (IPIC) during a 1-year period and a cohort of children who presented to pediatric emergency departments (EDs) after unintentional injection of an AI ...
Matitiahu Berkovitch +2 more
exaly +3 more sources
Civilian Adult Self Injections of Atropine – Trimedoxime (TMB4) Auto-Injectors
Clinical Toxicology, 2006The clinical effects of self injections of atropine-trimedoxime auto-injectors distributed to the civilian population as a field antidote for nerve agent attack were assessed.Data on self injections by adults (> or = 18 years) were collected from the Israel Poison Information Center and a hospital Emergency Department's records during a 2-year period ...
Matitiahu Berkovitch +2 more
exaly +3 more sources
Influence of Trimedoxime Bromide on Degradation of Benactyzine in Acidic Injectable Solutions
European Journal of Pharmaceutical Sciences, 1999 The stability of benactyzine in a multicomponent injectable antidote formulation in deuterium oxide was studied in the presence of various concentrations of trimedoxime bromide. Benactyzine was found to be more stable in the absence of trimedoxime bromide and its degradation rate accelerated linearly with increasing concentrations of trimedoxime ...
S, Rubnov +3 more
exaly +3 more sources
Stability of Trimedoxime in Concentrated Acidic Injectable Solutions [PDF]
Military Medicine, 1999 The degradation of trimedoxime in concentrated (114 mg/ml) acidic solutions was studied at several temperatures in the pH range 3.0 to 4.3. The degradation profile showed a relationship indicative of first-order kinetics. Trimedoxime was found to be stable in the pH range 3.0 to 3.8, with maximum stability at pH 3.0.
S, Rubnov +4 more
exaly +3 more sources
Archives of Toxicology, 1995
This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The effectiveness of trimedoxime, obidoxime, pralidoxime and HI-6, given with atropine and diazepam, was tested in the treatment of poisoning with 2 LD50 of the insecticides.
Milan Jokanovic, M Maksimović
exaly +3 more sources
This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The effectiveness of trimedoxime, obidoxime, pralidoxime and HI-6, given with atropine and diazepam, was tested in the treatment of poisoning with 2 LD50 of the insecticides.
Milan Jokanovic, M Maksimović
exaly +3 more sources
Trimedoxime and HI-6: Kinetic Comparison After Intravenous Administration to Mice
Pharmacology & Toxicology, 1996Abstract: The intravenous pharmacokinetics of the oximes HI‐6 (pyridinium‐1‐(((4‐carbamoi 1‐pyridinio)metoxy)rnethyl)‐2‐(hydroxyiminomethyl)dichloride monohydrate), (132.54 μmol/kg) and trimedoxime (1,1′‐(1,3′‐propanedyl)bis((4‐hydroxyimino) methyl)‐pyridinium dibromide), (55,98 μmol/kg) in mice was investigated. The concentrations of oximes in plasma
M Maksimović
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A Comparison of the Potency of Trimedoxime and Other Currently Available Oximes to Reactivate Tabun-Inhibited Acetylcholinesterase and Eliminate Acute Toxic Effects of Tabun. [PDF]
Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, 2005 Tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) belongs to highly toxic organophosphorus compounds misused as chemical warfare agents for military as well as terroristic purposes. It differs from other highly toxic organophosphates by its chemical structure and by the fact that tabun-inhibited acetylcholinesterase is extraordinarily difficult to ...
Kamil Kuča, Jiri Kassa, Jiří Cabal
exaly +3 more sources
Experimental and Toxicologic Pathology, 2001
In this study we have examined the effects of atropine, trimedoxime (TMB-4) and methylprednisolone (MP) on the development of organophosphate-induced delayed polyneuropathy (OPIDP) in the hen. The birds were treated with standard neuropathic dose of diisopropylfluorophosphate (DFP) (1.1 mg/kg, sc), which produced OPIDP that could be graded as 5 on the ...
M, Jokanović +5 more
openaire +2 more sources
In this study we have examined the effects of atropine, trimedoxime (TMB-4) and methylprednisolone (MP) on the development of organophosphate-induced delayed polyneuropathy (OPIDP) in the hen. The birds were treated with standard neuropathic dose of diisopropylfluorophosphate (DFP) (1.1 mg/kg, sc), which produced OPIDP that could be graded as 5 on the ...
M, Jokanović +5 more
openaire +2 more sources