Results 81 to 90 of about 271 (121)

Antimicrobial, antimalarial, and antileishmanial activities of mono- and bis-quaternary pyridinium compounds. [PDF]

Chem Biol Drug Des, 2010
Bharate SB, Thompson CM.
europepmc   +1 more source

A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication. [PDF]

Toxicol Res (Camb), 2016
Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L, Malinak D, Gorecki L, Musilek K, Kuca K.   +12 more
europepmc   +1 more source

Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study. [PDF]

Int J Mol Sci, 2013
Sepsova V, Karasova JZ, Korabecny J, Dolezal R, Zemek F, Bennion BJ, Kuca K.   +6 more
europepmc   +1 more source

Tegavivint triggers TECR-dependent nonapoptotic cancer cell death. [PDF]

Nat Chem Biol
Leak L, Wang Z, Joseph AJ, Johnson B, Chan AA, Decosto CM, Magtanong L, Ko PJ, Lee WC, Ritho J, Manukian S, Millner A, Chitkara S, Salinas JJ, Skouta R, Rees MG, Ronan MM, Roth JA, Myers CL, Moffat J, Boone C, Bensinger SJ, Nathanson DA, Atilla-Gokcumen GE, Moding EJ, Dixon SJ.   +25 more
europepmc   +1 more source

Towards Completion of the "Periodic Table" of Di-2-Pyridyl Ketoxime. [PDF]

Molecules
Stamou C, Polyzou CD, Lada ZG, Konidaris KF, Perlepes SP.   +4 more
europepmc   +1 more source

Efficacy of Trimedoxime in Mice Poisoned with Dichlorvos, Heptenophos or Monocrotophos [PDF]

Basic and Clinical Pharmacology and Toxicology, 2005
Abstract: The aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy‐substituted organophosphorus inhibitors. In order to assess the protective efficacy of trimedoxime against dichlorvos, heptenophos or monocrotophos, median effective doses and efficacy half‐times were calculated.
Biljana Antonijević
exaly   +14 more sources

The effect of trimedoxime on acetylcholinesterase and on the cholinergic system of the rat bladder [PDF]

Journal of Applied Biomedicine, 2010
Summary Trimedoxime is a bisquaternary oxime that is widely used in the treatment of organophosphorous poisoning caused by tabun and paraoxon. We tested its affinity to acetylcholinesterase (AChE), its mechanism of interaction and effect on the cholinergic system of the rat bladder.
Ondřej Soukup, Josef Fusek, Kamil Kuca   +2 more
exaly   +3 more sources

Pediatric poisoning from trimedoxime (TMB4) and atropine automatic injectors

Journal of Pediatrics, 2005
To describe the effects of combined trimedoxime (TMB4) and atropine poisoning from automatic injectors (AI) in children.Data was collected from two sources: calls to the Israel Poison Information Center (IPIC) during a 1-year period and a cohort of children who presented to pediatric emergency departments (EDs) after unintentional injection of an AI ...
Matitiahu Berkovitch, Eran Kozer
exaly   +4 more sources

Stability of Trimedoxime in Concentrated Acidic Injectable Solutions [PDF]

Military Medicine, 1999
The degradation of trimedoxime in concentrated (114 mg/ml) acidic solutions was studied at several temperatures in the pH range 3.0 to 4.3. The degradation profile showed a relationship indicative of first-order kinetics. Trimedoxime was found to be stable in the pH range 3.0 to 3.8, with maximum stability at pH 3.0.
S, Rubnov, S, Amisar, D, Levy, S, Muchtar, H, Schneider   +4 more
exaly   +4 more sources

Influence of trimedoxime bromide on degradation of benactyzine in acidic injectable solutions

European Journal of Pharmaceutical Sciences, 1999
The stability of benactyzine in a multicomponent injectable antidote formulation in deuterium oxide was studied in the presence of various concentrations of trimedoxime bromide. Benactyzine was found to be more stable in the absence of trimedoxime bromide and its degradation rate accelerated linearly with increasing concentrations of trimedoxime ...
S, Rubnov, S, Amisar, Y, Lomnicky, H, Schneider   +3 more
exaly   +4 more sources