Results 81 to 90 of about 177 (110)

An Evaluation of Therapeutic and Reactivating Effects of Newly Developed Oximes (K156, K203) and Commonly Used Oximes (Obidoxime, Trimedoxime, HI-6) in Tabun-Poisoned Rats and Mice

Toxicology, 2008
The potency of newly developed monoxime bispyridinium compounds (K156, K203) in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.
Kamil Kuča, Jiri Kassa, Kamil Musílek
exaly   +3 more sources

Partition of Bispyridinium Oximes (Trimedoxime and K074) Administered in Therapeutic Doses Into Different Parts of the Rat Brain

Journal of Pharmaceutical and Biomedical Analysis, 2011
The penetration of acetylcholinesterase reactivators (oximes) into the central nervous system is typically restricted by the blood-brain barrier. Although oximes are highly hydrophilic compounds, some contradictory results confirming permeation into the brain exist.
Kamil Kuča, Ladislav Novotný, Jana Žďárová Karasová   +2 more
exaly   +3 more sources

Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma

Journal of Applied Toxicology, 2011
ABSTRACTK027 [1‐(4‐hydroxyiminomethylpyridinium)‐3‐(4‐carbamoylpyridinium)–propane dibromide] is a promising new reactivator of organophosphate‐ or organophosphonate‐inhibited acetylcholinesterase (AChE) with low acute toxicity and broad spectrum efficacy. The aim of the present study was to compare the pharmacokinetics of both compounds.
Jana Zdarova, Karasova, Jaroslav, Chladek, Milos, Hroch, Fusek, Josef, Daniela, Hnidkova, Kamil, Kuca   +5 more
openaire   +2 more sources

Hydrolysis of acetylthiocholine iodide and reactivation of phoxim-inhibited acetylcholinesterase by pralidoxime chloride, obidoxime chloride and trimedoxime

Archives of Toxicology, 2007
The hydrolysis of acetylthiocholine iodide (ATCh) by pralidoxime chloride (2-PAM Cl), trimedoxime (TMB(4)) and obidoxime chlpride (LUH(6)) was studied at pH 5.8-8.0 and incubation temperature from 5 to 40 degrees C in vitro. Significant ATCh hydrolysis by 2-PAM Cl, TMB(4) and LUH(6) was found, with the exceptions of those at pH 7.0, 6.2 and 5.8 at 5 ...
Yi Hui, Zhang, Tadashi, Miyata, Zhu Jian, Wu, Gang, Wu, Lian Hui, Xie   +4 more
openaire   +2 more sources

Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo

Chemico-Biological Interactions, 2010
Up to now, intensive attempts to synthesize a universal reactivator able to reactivate cholinesterases inhibited by all types of nerve agents/organophosphates were not successful. Therefore, another approach using a combination of two reactivators differently reactivating enzyme was used: in rats poisoned with tabun and treated with combination of ...
Jiri, Bajgar, Jana Zdarova, Karasova, Jiri, Kassa, Jiri, Cabal, Josef, Fusek, Vaclav, Blaha, Sandra, Tesarova   +6 more
openaire   +2 more sources

Reactivating and cholinolytic action of trimedoxime bromide at the neuromuscular junction of warm-blooded animals

Neurophysiology, 1988
The reactivating and cholinolytic action of trimedoxime bromide was evaluated during experiments on rat soleus and diaphragm muscles accoridng to the amplitude and time course of miniature end-plate potentials and currents (MEPP and MEPC respectively). This agent reactivates acetylcholinesterase (AChE) phosphorylation.
R. A. Giniatullin, I. A. Shabunova, E. N. Nikol'skii, É. A. Bukharaeva   +3 more
openaire   +1 more source

Therapeutic Efficacy of a Novel Bispyridinium Oxime K203 and Commonly Used Oximes (HI-6, Obidoxime, Trimedoxime, Methoxime) in Soman-Poisoned Male Rats and Mice [PDF]

Journal of Applied Biomedicine, 2013
The potency of a novel oxime K203 in reactivating soman-inhibited acetylcholinesterase and reducing acute toxicity of soman was compared with commonly used oximes (HI-6, obidoxime, trimedoxime, methoxime) using in vivo methods. The study determining percentage of reactivation of soman-inhibited blood and tissue acetylcholinesterase in rats showed that ...
Jiri Kassa, Jana Žďárová Karasová
exaly   +2 more sources

Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats

Toxicology Letters, 2006
43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries, 20-24 September 2006, Cavtat ...
Stefanović, D., Antonijević, Biljana, Bokonjić, Dubravko, Milovanović, Zoran A., Stojiljković, Miloš P., Nedeljković, Mirjana   +5 more
openaire   +2 more sources

A Comparison of the Therapeutic and Reactivating Efficacy of Newly Developed Oximes (K117, K127) and Currently Available Oximes (Obidoxime, Trimedoxime, HI-6) in Tabun-Poisoned Rats and Mice

Drug and Chemical Toxicology, 2008
The potency of newly developed bispyridinium compounds (K117, K127) to reactivate tabun-inhibited acetylcholinesterase and reduce tabun-induced lethal toxic effects was compared with currently available oximes (obidoxime, trimedoxime, oxime HI-6) by using in vivo methods.
Young-Sik Jung, Kamil Kuča, Jiri Kassa
exaly   +3 more sources

Five oximes (K‐27, K‐48, obidoxime, HI‐6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl‐paraoxon

Journal of Applied Toxicology, 2007
AbstractThere is a clear need for broad‐spectrum cholinesterase reactivators (active against a multitude of organophosphorus ester enzyme inhibitors) with a higher efficacy than pralidoxime. The purpose of the study was to quantify in vivo the extent of oxime‐conferred protection, using methyl‐paraoxon [dimethyl p‐nitrophenyl phosphate; (methyl‐POX ...
G A, Petroianu, S M, Nurulain, N, Nagelkerke, M, Shafiullah, J, Kassa, K, Kuca   +5 more
openaire   +2 more sources