Toxicology Mechanisms and Methods, 2009 Introduction. The new K-oximes, K-27 [1-(4-hydroxyimino-methylpyridinium)-4-(4-carbamoylpyridinium) propane dibromide] and K-48 [1-(4-hydroxyimino-methylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide], show good in vitro efficacy in protecting acetylcholinesterase from inhibition by different organophosphorus compounds (OPCs), including nerve ...
Lorke, D. E. +5 more
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Курс лекций по фармакологии. Т. 1 [PDF]
, 2013 ФАРМАКОЛОГИЯФАРМАКОКИНЕТИКАЛЕКАРСТВАГОРМОНЫВИТАМИНЫПредставлена краткая информация по основным группам лекарственных средств. Первая часть пособия включает обзор общих сведений по фармакокинетике и фармакодинамике, классификации лекарственных средств, их
Конорев, М. Р. +2 more
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Formulation And Evaluation Of Fast Disintegrating Sublingual Atropine Tablets For The Potential Treatment Of Acute Organophosphates Toxicity [PDF]
, 2017 Organophosphates (OP) are chemicals found in certain pesticides and in nerve agents such as sarin. Toxicity with these agents can lead to death. On August 2013, 1,300 civilians were killed using sarin gas in Syria by the Assad regimen.
Aodah, Alhussain
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Synthesis of novel acetylcholinesterase reactivators of isoquinolinic type [PDF]
, 2017 Univerzita Karlova Farmaceutická fakulta v Hradci Králové Katedra organické a bioorganické chemie Kandidát: Miroslava Hozová Školiteľ: PharmDr. Jaroslav Roh, Ph.D. Konzultant: RNDr. Dávid Maliňák, Ph.D.
Hozová, Miroslava
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Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice. [PDF]
Toxics, 2022 Kassa J +4 more
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Dynamique structurale de l'acetylcholinesterase et ses implications dans la conception de réactivateurs [PDF]
, 2015 Acetylcholinesterase (AChE), one of nature fastest enzyme, is the target of multiple toxics,including organophosphate nerve agents (OP). In the first part of this thesis I present thestructure-based development of a new uncharged reactivator, which ...
Santoni, Gianluca
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In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. [PDF]
Chem Res Toxicol, 2023 Váňová N +5 more
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Journal of Applied Biomedicine, 2015 The potency of two novel oximes (K920, K923) to reactivate tabun-inhibited acetylcholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods. The study determining percentage of reactivation of tabun-inhibited peripheral acetylcholinesterase (diaphragm) and central acetylcholinesterase ...
Jiri Kassa +3 more
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A COMPARISON OF THE NEUROPROTECTIVE EFFICACY OF INDIVIDUAL OXIMES (HI-6, TRIMEDOXIME, K203) AND THEIR MIXTURES (HI-6 + TRIMEDOXIME, HI-6 + K203) IN CYCLOSARIN-POISONED RATS [PDF]
Military Medical Science Letters, 2011 Jiří Kassa, Jana Žďárová Karasová
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Piridinijevi, imidazolijevi i kinuklidinijevi spojevi: toksičnost i protuotrovno djelovanje naspram nervnim otrovima tabunu i somanu [PDF]
, 2006 This paper discusses the toxicity and antidotal effects of 32 compounds. Screening studies have shown that these compounds combined with atropine are effective antidotes against the organophosphate nerve agents Tabun and/or Soman, having a therapeutic ...
Elsa Reiner, Vera Simeon-Rudolf
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