Detoksikacija živčanih bojnih otrova [PDF]
, 2020 Phosphylation of the pivotal enzyme acetylcholinesterase (AChE) by nerve agents (NAs) leads to irreversible inhibition of the enzyme and accumulation of neurotransmitter acetylcholine, which induces cholinergic crisis, that is, overstimulation of ...
Nikolina Maček Hrvat, Zrinka Kovarik
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Antidotski efekat kombinacija obidoksim/HI-6 i memantina kod miševa trovanih somanom, dihlorvosom ili heptenofosom [PDF]
, 2011 Introduction/Aim. In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy.
Antonijević, Biljana +3 more
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“People are afraid of getting injections”:Feasibility of community-placed atropine auto-injectors in treating organophosphate poisoning in Sri Lanka [PDF]
IntroductionOrganophosphorus insecticide poisoning remains a major problem in rural low- and middle-income communities. Atropine auto-injectors are used for organophosphorus nerve agent poisoning, but not organophosphorus insecticide poisoning.
Balasuriya, Theekshana +7 more
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Advances in toxicology and medical treatment of chemical warfare nerve agents [PDF]
, 2012 Organophosphorous (OP) Nerve agents (NAs) are known as the deadliest chemical warfare agents. They are divided into two classes of G and V agents. Most of them are liquid at room temperature.
Emadodin Darchini-Maragheh +2 more
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A Comparison of the Reactivating and Therapeutic Efficacy of Two Newly Developed Oximes (K727 and K733) with Oxime K203 and Trimedoxime in Tabun‐Poisoned Rats and Mice [PDF]
Basic & Clinical Pharmacology & Toxicology, 2014 AbstractThe reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun‐poisoned rats and mice. The oxime‐induced reactivation of tabun‐inhibited acetylcholinesterase was measured in diaphragm and brain of tabun‐poisoned rats.
Jiri, Kassa +4 more
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Efeito reativador de oximas frente à inibição da enzima acetilcolinesterase cerebral induzida pelo malation e malaoxon [PDF]
, 2012 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2009.O malation e um pesticida organofosforado (OF) e sua toxicidade depende da sua bioativacao a ...
Santos, Alessandra Antunes dos
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Evaluation of the activity of aromatic aldehydes and their oximes against human erythrocyte acetylcholinesterase enzyme [PDF]
, 2017 Considering the therapeutic importance of the acetylcholinesterase inhibitor drugs, as well, enzyme regenerators drugs, in cases of organophosphate poisoning.
Arlan de Assis Gonsalves +3 more
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Evaluation of the Potency of Two Novel Bispyridinium Oximes (
Basic & Clinical Pharmacology & Toxicology, 2013 AbstractThe ability of two newly developed bispyridinium oximes (K456, K458) to reduce tabun‐induced acute neurotoxic signs and symptoms was compared with oxime K203 and trimedoxime using the functional observational battery. The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (200 μg/
Jiri, Kassa +2 more
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Piridinijevi oksimi: razlozi za njihov odabir kao kauzalnih antidota protiv otrovanja organofosfatima i sadašnja rješenja za autoinjektore [PDF]
, 2006 During the last five decades, five pyridinium oximes were found to be worthy of use as antidotes against nerve agents in humans: pralidoxime, in a form of chloride or PAM-2 Cl and mesylate or P2S (against sarin, cyclosarin and VX), trimedoxime or TMB-4 ...
Milan Jokanović +1 more
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A comparison of reactivating and therapeutic efficacy of the oxime K203 and its fluorinated analog (KR-22836) with currently available oximes (obidoxime, trimedoxime, HI-6) against tabun in rats and mice [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2010 The potency of newly developed bispyridinium compound K203 and its fluorinated analog KR-22836 in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.
Jiri, Kassa +5 more
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