HPLC metoda za odredivanje oksima hi-6 i trimedoksima u plazmi
, 1995 A high-performance liquid chromatographic (HPLC) assay was developed to determine HI-6 and trimedoxime concentrations in small volumes of plasma. The HPLC system comprised a high-pressure pump (model 2150), a multiwavelenght detector (model 2140) set at ...
Milić, B +2 more
core +7 more sources
Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats. [PDF]
Int J Mol Sci, 2008 The therapeutical efficacies of eleven oxime-based acetylcholinesterase reactivators were compared in an in vivo (rat model) study of treatment of intoxication caused by tabun.
Karasova JZ +5 more
europepmc +2 more sources
Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats. [PDF]
Int J Mol Sci, 2009 Seven new oxime-based acetylcholinesterase reactivators were compared with three currently available ones (obidoxime, trimedoxime, HI-6) for their ability to lessen cholinesterase inhibition in blood and brain of cyclosarin-treated rats.
Karasova JZ +5 more
europepmc +2 more sources
In vitro ability of currently available oximes to reactivate organophosphate pesticide-inhibited human acetylcholinesterase and butyrylcholinesterase. [PDF]
Int J Mol Sci, 2011 We have in vitro tested the ability of common, commercially available, cholinesterase reactivators (pralidoxime, obidoxime, methoxime, trimedoxime and HI-6) to reactivate human acetylcholinesterase (AChE), inhibited by five structurally different ...
Jun D, Musilova L, Musilek K, Kuca K.
europepmc +2 more sources
Therapeutic Efficacy of Different Antidotal Mixtures Against Poisoning with GF-Agent in Mice
Acta Medica, 2004 The toxicity of cyclohexyl methylphosphonofluoridate (GF-agent; cyclosarin) and therapeutic efficacy of four oximes (trimedoxime, methoxime, obidoxime and HI-6) in combination with atropine or benactyzine (BNZ) was studied in mice.
Lucie Bartošová +3 more
doaj +1 more source
Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro. [PDF]
Int J Mol Sci, 2010 We have evaluated in vitro the potency of 23 oximes to reactivate human erythrocyte acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BChE) inhibited by racemic leptophos-oxon (O-[4-bromo-2,5-dichlorophenyl]-O-methyl phenyl-phosphonate), a ...
Jun D +5 more
europepmc +2 more sources
Acta Medica, 2006 In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals.
Gabriela Kunešová, Jiří Kassa
doaj +1 more source
Acta Medica, 2010 The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj +1 more source
A COMPARISON OF THE POTENCY OF TRIMEDOXIME AND OTHER CURRENTLY AVAILABLE OXIMES TO REACTIVATE TABUN-INHIBITED ACETYLCHOLINESTERASE AND ELIMINATE ACUTE TOXIC EFFECTS OF TABUN [PDF]
Biomedical Papers, 2005 Tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) belongs to highly toxic organophosphorus compounds misused as chemical warfare agents for military as well as terroristic purposes. It differs from other highly toxic organophosphates by its chemical structure and by the fact that tabun-inhibited acetylcholinesterase is extraordinarily difficult to ...
Jirí, Kassa, Kamil, Kuca, Jirí, Cabal
openaire +2 more sources
A Comparison of the Reactivating and Therapeutic Efficacy of Two Newly Developed Oximes (K727 and K733) with Oxime K203 and Trimedoxime in Tabun‐Poisoned Rats and Mice [PDF]
Basic & Clinical Pharmacology & Toxicology, 2014 AbstractThe reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun‐poisoned rats and mice. The oxime‐induced reactivation of tabun‐inhibited acetylcholinesterase was measured in diaphragm and brain of tabun‐poisoned rats.
Jiri, Kassa +4 more
openaire +2 more sources