Results 21 to 30 of about 328 (142)
An Efficient Synthesis of Pyridoxal Oxime Derivatives under Microwave Irradiation [PDF]
, 2014 Quaternary salts of pyridoxal oxime have been synthesized by the quaternization of pyridoxal oxime with substituted phenacyl bromides using microwave heating.
Bušić, Valentina +3 more
core +4 more sources
The effect of trimedoxime on acetylcholinesterase and on the cholinergic system of the rat bladder [PDF]
Journal of Applied Biomedicine, 2010 Summary Trimedoxime is a bisquaternary oxime that is widely used in the treatment of organophosphorous poisoning caused by tabun and paraoxon. We tested its affinity to acetylcholinesterase (AChE), its mechanism of interaction and effect on the cholinergic system of the rat bladder.
Ondřej Soukup +7 more
openaire +1 more source
Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos [PDF]
, 2006 The development of effective antidotes against organophosphates such as dichlorvos has been a persistent challenge over the past decades. Therapy of organophosphate poisoning is based on the administration of atropine and oxime as standard antidotes. The
Antonijević, Biljana +5 more
core +2 more sources
Acta Medica, 2012 The reactivating and therapeutic efficacy of two combinations of oximes (HI‑6 + trimedoxime and HI‑6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI‑6, trimedoxime, K203) using in vivo methods.
Jiří Kassa +4 more
doaj +1 more source
Influence of trimedoxime bromide on degradation of benactyzine in acidic injectable solutions
European Journal of Pharmaceutical Sciences, 1999 The stability of benactyzine in a multicomponent injectable antidote formulation in deuterium oxide was studied in the presence of various concentrations of trimedoxime bromide. Benactyzine was found to be more stable in the absence of trimedoxime bromide and its degradation rate accelerated linearly with increasing concentrations of trimedoxime ...
S, Rubnov +3 more
openaire +2 more sources
Uticaj natrijum bikarbonata i standardnih antidota na acido-bazni status pacova trovanih dihlorvosom [PDF]
, 2004 The aim of the present work was to examine potential beneficial role of sodium bicarbonate (3 mmol/kg ip) on protective potency of trimedoxime (10 mg/kg im), obidoxime (10 mg/kg im) and atropine (10 mg/kg im) in rats poisoned with dichlorvos.
Antonijević, Biljana +5 more
core +1 more source
Acta Medica, 2006 In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals.
Gabriela Kunešová, Jiří Kassa
doaj +1 more source
A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats [PDF]
Toxicology Mechanisms and Methods, 2017 The ability of two newly developed bispyridinium oximes (K920, K923) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the oxime K203 and trimedoxime using a functional observational battery (FOB). The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (130 μg/
Jiri, Kassa +3 more
openaire +3 more sources
Effect of Diisopropyl Phosphorofluoridate in Some Aspects of Carbohydrate Metabolism [PDF]
, 2013 An acute dose of DFP equivalent to 50 per cent of the LD50 cause glycogenolysis and hyperglycemia in male albino rats. The hyperglycemic effect can atleast be partially suppressed by the administration of insulin.
Chatterjee, A. K., Kaveeshwar, U.
core +2 more sources
Acta Medica, 2010 The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj +1 more source