Evaluation of Potency of Known Oximes (Pralidoxime, Trimedoxime, HI-6, Methoxime, Obidoxime) to in vitro Reactivate Acetylcholinesterase Inhibited by Pesticides (Chlorpyrifos and Methylchlorpyrifos and Nerve Agent (Russian VX) [PDF]
Acta Medica, 2007 Nerve agents and pesticides belong to the group of organophosphates. They are able to inhibit irreversibly the enzyme acetylcholinesterase (AChE). Acetylcholinesterase reactivators were designed for the treatment of nerve agent intoxications.
Kamil Musílek, Kamil Kuča, Daniel Jun
doaj +3 more sources
Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects. [PDF]
Int J Mol Sci, 2020 Abstract The organophosphorus compounds (OP) are used as both chemical weapons and pesticides. However, these agents are very dangerous and toxic to humans, animals, and the environment. Thus, investigations with reactivators have been deeply developed in order to design new antidotes with better efficiency, as well as greater spectrum of ...
de Castro AA +6 more
europepmc +5 more sources
Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes
Journal of Chemistry, Volume 2021, Issue 1, 2021., 2021 For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries. Apart from the agricultural pesticide poisoning, terrorists have used these organophosphorus compounds to attack civilian populations in some ...
Rauda A. Mohamed +8 more
wiley +1 more source
Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. [PDF]
Int J Mol Sci, 2013 Acetylcholinesterase (AChE) reactivators (oximes) are compounds predominantly targeting the active site of the enzyme. Toxic effects of organophosphates nerve agents (OPNAs) are primarily related to their covalent binding to AChE and butyrylcholinesterase (BChE), critical detoxification enzymes in the blood and in the central nervous system (CNS ...
Zemek F, Zdarova JK, Sepsova V, Kuca K.
europepmc +4 more sources
Organophosphorus Nerve Agents: Types, Toxicity, and Treatments
Journal of Toxicology, Volume 2020, Issue 1, 2020., 2020 Organophosphorus compounds are extensively used worldwide as pesticides which cause great hazards to human health. Nerve agents, a subcategory of the organophosphorus compounds, have been produced and used during wars, and they have also been used in terrorist activities.
Sudisha Mukherjee +2 more
wiley +1 more source
Acta Medica, 2012 The reactivating and therapeutic efficacy of two combinations of oximes (HI‑6 + trimedoxime and HI‑6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI‑6, trimedoxime, K203) using in vivo methods.
Jiří Kassa +4 more
doaj +1 more source
Acta Medica, 2006 In the past, scientists focused on the development of antidotes (mainly anticholinergics in combination with reactivators of inhibited acetylcholinesterase – oximes) to increase the number of surviving nerve agent-intoxicated individuals.
Gabriela Kunešová, Jiří Kassa
doaj +1 more source
Acta Medica, 2010 The studies dealing with mechanism of organophosphates (OP)/nerve agent action, prophylaxis and treatment of intoxications is a very hot topic at present.
Jiří Bajgar
doaj +1 more source
A Comparison of the Reactivating and Therapeutic Efficacy of Two Newly Developed Oximes (K727 and K733) with Oxime K203 and Trimedoxime in Tabun‐Poisoned Rats and Mice [PDF]
Basic & Clinical Pharmacology & Toxicology, 2014 AbstractThe reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun‐poisoned rats and mice. The oxime‐induced reactivation of tabun‐inhibited acetylcholinesterase was measured in diaphragm and brain of tabun‐poisoned rats.
Jiri, Kassa +4 more
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A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats [PDF]
Toxicology Mechanisms and Methods, 2017 The ability of two newly developed bispyridinium oximes (K920, K923) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the oxime K203 and trimedoxime using a functional observational battery (FOB). The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (130 μg/
Jiri, Kassa +3 more
openaire +3 more sources