The Evaluation of the Potency of Newly Developed Oximes (K727, K733) and Trimedoxime to Counteract Acute Neurotoxic Effects of Tabun in Rats [PDF]
Acta Medica, 2016 Aim: The ability of two newly developed oximes (K727, K733) to reduce tabun-induced acute neurotoxic signs and symptoms was evaluated and compared with currently available trimedoxime in rats.
Jiří Kassa +2 more
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Evaluation of Potency of Known Oximes (Pralidoxime, Trimedoxime, HI-6, Methoxime, Obidoxime) to in vitro Reactivate Acetylcholinesterase Inhibited by Pesticides (Chlorpyrifos and Methylchlorpyrifos and Nerve Agent (Russian VX) [PDF]
Acta Medica, 2007 Nerve agents and pesticides belong to the group of organophosphates. They are able to inhibit irreversibly the enzyme acetylcholinesterase (AChE). Acetylcholinesterase reactivators were designed for the treatment of nerve agent intoxications.
Kamil Musílek, Kamil Kuča, Daniel Jun
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Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects. [PDF]
Int J Mol Sci, 2020 Abstract The organophosphorus compounds (OP) are used as both chemical weapons and pesticides. However, these agents are very dangerous and toxic to humans, animals, and the environment. Thus, investigations with reactivators have been deeply developed in order to design new antidotes with better efficiency, as well as greater spectrum of ...
de Castro AA +6 more
europepmc +6 more sources
Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. [PDF]
Int J Mol Sci, 2013 Acetylcholinesterase (AChE) reactivators (oximes) are compounds predominantly targeting the active site of the enzyme. Toxic effects of organophosphates nerve agents (OPNAs) are primarily related to their covalent binding to AChE and butyrylcholinesterase (BChE), critical detoxification enzymes in the blood and in the central nervous system (CNS ...
Zemek F, Zdarova JK, Sepsova V, Kuca K.
europepmc +5 more sources
Acta Medica, 2012 The reactivating and therapeutic efficacy of two combinations of oximes (HI‑6 + trimedoxime and HI‑6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI‑6, trimedoxime, K203) using in vivo methods.
Jiří Kassa +4 more
doaj +2 more sources
Toxicology Mechanisms and Methods, 2009 Introduction. The new K-oximes, K-27 [1-(4-hydroxyimino-methylpyridinium)-4-(4-carbamoylpyridinium) propane dibromide] and K-48 [1-(4-hydroxyimino-methylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide], show good in vitro efficacy in protecting acetylcholinesterase from inhibition by different organophosphorus compounds (OPCs), including nerve ...
Lorke, D. E. +5 more
openaire +4 more sources
Journal of Applied Toxicology, 2011 ABSTRACTK027 [1‐(4‐hydroxyiminomethylpyridinium)‐3‐(4‐carbamoylpyridinium)–propane dibromide] is a promising new reactivator of organophosphate‐ or organophosphonate‐inhibited acetylcholinesterase (AChE) with low acute toxicity and broad spectrum efficacy. The aim of the present study was to compare the pharmacokinetics of both compounds.
Jana Zdarova, Karasova +5 more
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Evaluation of the Potency of Two Novel Bispyridinium Oximes (
Basic & Clinical Pharmacology & Toxicology, 2013 AbstractThe ability of two newly developed bispyridinium oximes (K456, K458) to reduce tabun‐induced acute neurotoxic signs and symptoms was compared with oxime K203 and trimedoxime using the functional observational battery. The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (200 μg/
Jiri, Kassa +2 more
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Toxicology Letters, 2006 43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries, 20-24 September 2006, Cavtat ...
Stefanović, D. +5 more
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A COMPARISON OF THE NEUROPROTECTIVE EFFICACY OF INDIVIDUAL OXIMES (HI-6, TRIMEDOXIME, K203) AND THEIR MIXTURES (HI-6 + TRIMEDOXIME, HI-6 + K203) IN CYCLOSARIN-POISONED RATS [PDF]
Military Medical Science Letters, 2011 Jiří Kassa, Jana Žďárová Karasová
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