Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos [PDF]
Basic & Clinical Pharmacology & Toxicology, 2005 The aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy-substituted organophosphorus inhibitors.
Antonijević, Biljana +6 more
core +11 more sources
Evaluation of Potency of Known Oximes (Pralidoxime, Trimedoxime, HI-6, Methoxime, Obidoxime) to in vitro Reactivate Acetylcholinesterase Inhibited by Pesticides (Chlorpyrifos and Methylchlorpyrifos and Nerve Agent (Russian VX) [PDF]
Acta Medica, 2007 Nerve agents and pesticides belong to the group of organophosphates. They are able to inhibit irreversibly the enzyme acetylcholinesterase (AChE). Acetylcholinesterase reactivators were designed for the treatment of nerve agent intoxications.
Kamil Musílek, Kamil Kuča, Daniel Jun
doaj +3 more sources
Understanding the Interaction Modes and Reactivity of Trimedoxime toward MmAChE Inhibited by Nerve Agents: Theoretical and Experimental Aspects. [PDF]
Int J Mol Sci, 2020 Abstract The organophosphorus compounds (OP) are used as both chemical weapons and pesticides. However, these agents are very dangerous and toxic to humans, animals, and the environment. Thus, investigations with reactivators have been deeply developed in order to design new antidotes with better efficiency, as well as greater spectrum of ...
de Castro AA +6 more
europepmc +5 more sources
The Experimental Oxime K027-A Promising Protector From Organophosphate Pesticide Poisoning. A Review Comparing K027, K048, Pralidoxime, and Obidoxime. [PDF]
Front Neurosci, 2019 Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide. Standard therapy with atropine and established oxime-type enzyme reactivators (pralidoxime, obidoxime) is unsatisfactory.
Lorke DE, Petroianu GA.
europepmc +3 more sources
A complete, evidence-based review on novichok poisoning based on epidemiological aspects and clinical management. [PDF]
Front Toxicol, 2022 Background: The whole world has learned about the existence of a highly toxic neuro-paralytic substance called Novichok. A wide range of neuro-paralytic toxins were used during the wars of decades ago, which also had harmful and irreversible effects ...
Charejoo A +3 more
europepmc +3 more sources
Organophosphorus Nerve Agents: Types, Toxicity, and Treatments. [PDF]
J Toxicol, 2020 Organophosphorus compounds are extensively used worldwide as pesticides which cause great hazards to human health. Nerve agents, a subcategory of the organophosphorus compounds, have been produced and used during wars, and they have also been used in terrorist activities.
Mukherjee S, Gupta RD.
europepmc +2 more sources
Acetylcholinesterase reactivators (HI-6, obidoxime, trimedoxime, K027, K075, K127, K203, K282): structural evaluation of human serum albumin binding and absorption kinetics. [PDF]
Int J Mol Sci, 2013 Acetylcholinesterase (AChE) reactivators (oximes) are compounds predominantly targeting the active site of the enzyme. Toxic effects of organophosphates nerve agents (OPNAs) are primarily related to their covalent binding to AChE and butyrylcholinesterase (BChE), critical detoxification enzymes in the blood and in the central nervous system (CNS ...
Zemek F, Zdarova JK, Sepsova V, Kuca K.
europepmc +4 more sources
Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes
Journal of Chemistry, Volume 2021, Issue 1, 2021., 2021 For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries. Apart from the agricultural pesticide poisoning, terrorists have used these organophosphorus compounds to attack civilian populations in some ...
Rauda A. Mohamed +8 more
wiley +1 more source
Stability of Trimedoxime in Concentrated Acidic Injectable Solutions [PDF]
Military Medicine, 1999 The degradation of trimedoxime in concentrated (114 mg/ml) acidic solutions was studied at several temperatures in the pH range 3.0 to 4.3. The degradation profile showed a relationship indicative of first-order kinetics. Trimedoxime was found to be stable in the pH range 3.0 to 3.8, with maximum stability at pH 3.0.
S, Rubnov +4 more
openaire +2 more sources
Pesticides in the Modern World [PDF]
, 2021 The introduction of the synthetic organochlorine, organophosphate, carbamate and pyrethroid pesticides by 1950's marked the beginning of the modern pesticides era and a new stage in the agriculture development.
core +1 more source