Unequal efficacy of pyridinium oximes in acute organophosphate poisoning [PDF]
, 2007 The use of organophosphorus pesticides results in toxicity risk to non-target organisms. Organophosphorus compounds share a common mode of action, exerting their toxic effects primarily via acetylcholinesterase (AChE) inhibition.
Antonijević, Biljana +1 more
core +3 more sources
Examination of effectiveness of chemical scavengers as therapeutics in organophosphate poisoning [PDF]
, 2017 Cholinergic crisis triggered by inhibition of cholinesterases via organophosphorus nerve agents (OP) and pesticides is treated with atropine and a reactivator of inhibited cholinesterase, called oxime.
Bierwisch, Anne
core +2 more sources
Effects of Organophosphorus and Pyrethroid pesticides on antioxidant enzymes and reactivation effects of Pralidoxime: In vitro studies [PDF]
, 2022 The aim of this work was to investigate the inhibition effects of some organophosphate and pyrethroid pesticides on antioxidant enzymes. In addition, oximes were reported by reactivation ability against pesticide inhibited-acetylcholinesterase and we ...
Ayten Sagiroglu, Hatice Paluzar
core +2 more sources
A COMPARISON OF THE POTENCY OF TRIMEDOXIME AND OTHER CURRENTLY AVAILABLE OXIMES TO REACTIVATE TABUN-INHIBITED ACETYLCHOLINESTERASE AND ELIMINATE ACUTE TOXIC EFFECTS OF TABUN [PDF]
Biomedical Papers, 2005 Tabun (O-ethyl-N,N-dimethyl phosphoramidocyanidate) belongs to highly toxic organophosphorus compounds misused as chemical warfare agents for military as well as terroristic purposes. It differs from other highly toxic organophosphates by its chemical structure and by the fact that tabun-inhibited acetylcholinesterase is extraordinarily difficult to ...
Jirí, Kassa, Kamil, Kuca, Jirí, Cabal
openaire +2 more sources
The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice [PDF]
, 2017 Aim: The ability of four newly prepared reversible inhibitors of acetylcholinesterase (6-chlorotacrine, 7-phenoxytacrine, compounds 1 and 2) and currently used carbamate pyridostigmine to increase the resistance of mice against soman and the efficacy of ...
Abou-Donia +36 more
core +2 more sources
Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry
ChemistrySelect, Volume 9, Issue 27, July 18, 2024.Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran +13 more
wiley +1 more source
In vitro evaluation of neutral oximes as reactivators of parathion-inhibited electric eel acetylcholinesterase [PDF]
, 2017 Organophosphorus (OP) compounds are irreversible inhibitors of acetylcholinesterase (AChE) commonly used as pesticides and, unfortunately, as nerve agents in terrorist attacks.
Aguiar, Alcino P. +5 more
core +2 more sources
Therapeutic efficacy of a novel bispyridinium oxime K203 and commonly used oximes (HI-6, obidoxime, trimedoxime, methoxime) in soman-poisoned male rats and mice [PDF]
Journal of Applied Biomedicine, 2013 The potency of a novel oxime K203 in reactivating soman-inhibited acetylcholinesterase and reducing acute toxicity of soman was compared with commonly used oximes (HI-6, obidoxime, trimedoxime, methoxime) using in vivo methods. The study determining percentage of reactivation of soman-inhibited blood and tissue acetylcholinesterase in rats showed that ...
Jiří Kassa +2 more
openaire +1 more source
Translacija učinkovitosti piridinijevih oksima kod trovanja tabunom iz in vitro sustava u in vivo primjenu [PDF]
, 2015 Even if organophosphorus (OP) nerve agents were banned entirely, their presence would remain a problem as weapons of terror (like in Syria). Oxime antidotes currently used in medical practice still fall short of their therapeutic purpose, as they fail to
Jan Misik +4 more
core +2 more sources
Management of acute organophosphorus pesticide poisoning [PDF]
, 2008 Organophosphorus pesticide self-poisoning is an important clinical problem in rural regions of the developing world, and kills an estimated 200 000 people every year.
Eddleston, Michael +3 more
core +1 more source