Results 31 to 40 of about 271 (121)

A comparison of neuroprotective efficacy of two novel reactivators of acetylcholinesterase called K920 and K923 with the oxime K203 and trimedoxime in tabun-poisoned rats [PDF]

Toxicology Mechanisms and Methods, 2017
The ability of two newly developed bispyridinium oximes (K920, K923) to reduce tabun-induced acute neurotoxic signs and symptoms was compared with the oxime K203 and trimedoxime using a functional observational battery (FOB). The neuroprotective effects of the oximes studied combined with atropine on rats poisoned with tabun at a sublethal dose (130 μg/
Jiri, Kassa, Jan, Misik, Jana, Hatlapatkova, Jana, Zdarova Karasova   +3 more
openaire   +3 more sources

Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry

ChemistrySelect, Volume 9, Issue 27, July 18, 2024.
Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran, Kuntal Bose, Amrutha Chandran Thekkantavida, Riya Rachel Thomas, Karthika Anirudhan, Sandeep Bindra, Sooraj Sura, Haydara Ammar Hasan, Sunil Kumar, T. M. Rangarajan, Abdullah G. Al‐Sehemi, Prashant Gahtori, Hoon Kim, Bijo Mathew   +13 more
wiley   +1 more source

Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos [PDF]

, 2006
The development of effective antidotes against organophosphates such as dichlorvos has been a persistent challenge over the past decades. Therapy of organophosphate poisoning is based on the administration of atropine and oxime as standard antidotes. The
Biljana Antonijevic, Bokonjić, Dubravko, Mirjana Nedeljkovic, Stojiljković, Miloš P., Stefanović, D, Milovanović, Zoran A., Dubravko Bokonjic, Antonijević, Biljana, Danka Stefanovic, Nedeljković, M, Milos P. Stojiljkovic, Zoran A. Milovanovic   +11 more
core   +1 more source

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K920, K923) with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

Journal of Applied Biomedicine, 2015
The potency of two novel oximes (K920, K923) to reactivate tabun-inhibited acetylcholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods. The study determining percentage of reactivation of tabun-inhibited peripheral acetylcholinesterase (diaphragm) and central acetylcholinesterase ...
Jiri Kassa, Vendula Sepsova, Anna Horova, Kamil Musilek   +3 more
openaire   +1 more source

A Comparison of the Reactivating and Therapeutic Efficacy of Chosen Combinations of Oximes With Individual Oximes Against VX in Rats and Mice

, 2011
The ability of 2 combinations of oximes (HI-6 + trimedoxime and HI-6 + K203) to reactivate VX-inhibited acetylcholinesterase and reduce acute toxicity of VX was compared with the reactivating and therapeutic efficacy of antidotal treatment involving a ...
Vendula Sepsova, Filip Caisberger, Jiri Bajgar, Jiri Kassa, Jana Zdarova Karasova   +4 more
core   +1 more source

Effect of six oximes on acutely anticholinesterase inhibitor-induced oxidative stress in rat plasma and brain

, 2017
Beside the key inhibition of acetylcholinesterase (AChE), involvement of oxidative stress in organophosphate (OP)-induced toxicity has been supported by experimental and human studies.
Biljana Antonijevic, Antonijević, Evica, Đukić-Ćosić, Danijela, Kuca, Kamil, Spasojević-Kalimanovska, Vesna, Jelena Kotur-Stevuljevic, Kamil Musilek, Andrea Kosvancova, Evica Antonijevic, Kotur-Stevuljević, Jelena, Musilek, Kamil, Vesna Spasojevic-Kalimanovska, Kosvancova, Andrea, Antonijević, Biljana, Kamil Kuca, Danijela Djukic-Cosic   +15 more
core   +1 more source

Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice. [PDF]

Toxics, 2022
Kassa J, Timperley CM, Bird M, Green AC, Tattersall JEH.   +4 more
europepmc   +1 more source

Therapeutic and reactivating efficacy of oximes K027 and K203 against a direct acetylcholinesterase inhibitor

, 2016
As oxime-based structures are the only causal antidotes to organophosphate (OP)-inhibited acetylcholinesterase (AChE), the majority of studies on these have been directed towards their synthesis and testing.
Antonijević, Evica, Musilek, Kamil, Đukić-Ćosić, Danijela, Kuca, Kamil, Vučinić, Slavica, Antonijević, Biljana   +5 more
core   +1 more source

Molecular modeling of Mannich phenols as reactivators of human acetylcholinesterase inhibited by A-series nerve agents

, 2023
The A-series is the most recent generation of chemical warfare nerve agents (CWA) which act directly on the inhibition of the human acetylcholinesterase (HssAChE) enzyme. These compounds lack accurate experimental data on their physicochemical properties,
Vieira, Leandro A, Itamar Borges Jr, Franca, Tanos Celmar Costa, Joyce S.F.D. Almeida, Leandro A. Vieira, Almeida, Joyce S F D, Laplante, Steven, Martijn C. De Koning, Tanos C.C. França, Borges, Itamar, Steven R. LaPlante, De Koning, Martijn C   +11 more
core   +1 more source

In Vitro Evaluation of Oxidative Stress Induced by Oxime Reactivators of Acetylcholinesterase in HepG2 Cells. [PDF]

Chem Res Toxicol, 2023
Váňová N, Múčková L, Kalíšková T, Lochman L, Bzonek P, Švec F.   +5 more
europepmc   +1 more source