Results 111 to 120 of about 328 (142)

A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication. [PDF]

Toxicol Res (Camb), 2016
Nepovimova E, Korabecny J, Dolezal R, Nguyen TD, Jun D, Soukup O, Pasdiorova M, Jost P, Muckova L, Malinak D, Gorecki L, Musilek K, Kuca K.   +12 more
europepmc   +1 more source

Oximes: inhibitors of human recombinant acetylcholinesterase. A structure-activity relationship (SAR) study. [PDF]

Int J Mol Sci, 2013
Sepsova V, Karasova JZ, Korabecny J, Dolezal R, Zemek F, Bennion BJ, Kuca K.   +6 more
europepmc   +1 more source

Neurosteroids for the potential protection of humans against organophosphate toxicity. [PDF]

Ann N Y Acad Sci, 2016
Reddy DS.
europepmc   +1 more source

Detoxification of Organophosphate Poisoning Using Nanoparticle Bioscavengers. [PDF]

ACS Nano, 2015
Pang Z, Hu CM, Fang RH, Luk BT, Gao W, Wang F, Chuluun E, Angsantikul P, Thamphiwatana S, Lu W, Jiang X, Zhang L.   +11 more
europepmc   +1 more source

Towards Completion of the "Periodic Table" of Di-2-Pyridyl Ketoxime. [PDF]

Molecules
Stamou C, Polyzou CD, Lada ZG, Konidaris KF, Perlepes SP.   +4 more
europepmc   +1 more source

Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate (DFP): Comparison with the established oximes pralidoxime, obidoxime, trimedoxime, methoxime and HI-6

, 2018
Hasan, M. Y., Lorke, D. E., Nurulain, S. M., Kuca, K., Schmitt, A., Petmianu, G. A.   +5 more
openaire   +1 more source

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Pediatric poisoning from trimedoxime (TMB4) and atropine automatic injectors

The Journal of Pediatrics, 2005
To describe the effects of combined trimedoxime (TMB4) and atropine poisoning from automatic injectors (AI) in children.Data was collected from two sources: calls to the Israel Poison Information Center (IPIC) during a 1-year period and a cohort of children who presented to pediatric emergency departments (EDs) after unintentional injection of an AI ...
Eran, Kozer, Amnon, Mordel, Shmuael Bar, Haim, Mordechei, Bulkowstein, Matitiahu, Berkovitch, Yedidia, Bentur   +5 more
openaire   +2 more sources

Civilian Adult Self Injections of Atropine – Trimedoxime (TMB4) Auto-Injectors

Clinical Toxicology, 2006
The clinical effects of self injections of atropine-trimedoxime auto-injectors distributed to the civilian population as a field antidote for nerve agent attack were assessed.Data on self injections by adults (> or = 18 years) were collected from the Israel Poison Information Center and a hospital Emergency Department's records during a 2-year period ...
Yedidia, Bentur, Ido, Layish, Amir, Krivoy, Matitiahu, Berkovitch, Eran, Rotman, Shmuel Bar, Haim, Yoav, Yehezkelli, Eran, Kozer   +7 more
openaire   +2 more sources

Trimedoxime and HI‐6: Kinetic Comparison after Intravenous Administration to Mice

Pharmacology & Toxicology, 1996
Abstract: The intravenous pharmacokinetics of the oximes HI‐6 (pyridinium‐1‐(((4‐carbamoi 1‐pyridinio)metoxy)rnethyl)‐2‐(hydroxyiminomethyl)dichloride monohydrate), (132.54 μmol/kg) and trimedoxime (1,1′‐(1,3′‐propanedyl)bis((4‐hydroxyimino) methyl)‐pyridinium dibromide), (55,98 μmol/kg) in mice was investigated. The concentrations of oximes in plasma
B, Milic, M, Maksimovic, M, Nedelijkovic
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Pharmacokinetic study of two acetylcholinesterase reactivators, trimedoxime and newly synthesized oxime K027, in rat plasma

Journal of Applied Toxicology, 2011
ABSTRACTK027 [1‐(4‐hydroxyiminomethylpyridinium)‐3‐(4‐carbamoylpyridinium)–propane dibromide] is a promising new reactivator of organophosphate‐ or organophosphonate‐inhibited acetylcholinesterase (AChE) with low acute toxicity and broad spectrum efficacy. The aim of the present study was to compare the pharmacokinetics of both compounds.
Jana Zdarova, Karasova, Jaroslav, Chladek, Milos, Hroch, Fusek, Josef, Daniela, Hnidkova, Kamil, Kuca   +5 more
openaire   +2 more sources