Results 121 to 130 of about 499 (147)

Trimedoxime and HI-6: kinetic comparison after intravenous administration to mice.

Pharmacology & Toxicology, 1996
Abstract: The intravenous pharmacokinetics of the oximes HI‐6 (pyridinium‐1‐(((4‐carbamoi 1‐pyridinio)metoxy)rnethyl)‐2‐(hydroxyiminomethyl)dichloride monohydrate), (132.54 μmol/kg) and trimedoxime (1,1′‐(1,3′‐propanedyl)bis((4‐hydroxyimino) methyl)‐pyridinium dibromide), (55,98 μmol/kg) in mice was investigated. The concentrations of oximes in plasma
B. Milic, Matej Maksimović, M. Nedelijkovic   +2 more
semanticscholar   +3 more sources

A comparison of the reactivating and therapeutic efficacy of two novel bispyridinium oximes (K920, K923) with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

Journal of Applied Biomedicine, 2015
The potency of two novel oximes (K920, K923) to reactivate tabun-inhibited acetylcholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods. The study determining percentage of reactivation of tabun-inhibited peripheral acetylcholinesterase (diaphragm) and central acetylcholinesterase ...
J. Kassa, V. Sepsova, A. Horova, K. Musílek   +3 more
semanticscholar   +2 more sources

The evaluation of the reactivating and therapeutic efficacy of two novel oximes (K361 and K378) in comparison with the oxime K203 and trimedoxime in tabun-poisoned rats and mice

Toxicology Mechanisms and Methods, 2014
The potency of two newly developed oximes (K361 and K378) to reactivate tabun-inhibited cholinesterase and to reduce acute toxicity of tabun was compared with the oxime K203 and trimedoxime using in vivo methods. The study determining percentage of reactivation of tabun-inhibited diaphragm cholinesterase in poisoned rats showed that the reactivating ...
J. Kassa, V. Sepsova, M. Tůmová, K. Musílek, A. Horova   +4 more
semanticscholar   +3 more sources

A comparison of the neuroprotective efficacy of individual oxime (HI-6) and combinations of oximes (HI-6+trimedoxime, HI-6+K203) in soman-poisoned rats

Drug and Chemical Toxicology, 2011
The ability of two combinations of oximes (HI-6+trimedoxime, HI-6+K203) to reduce soman-induced acute neurotoxic signs and symptoms was compared with the neuroprotective efficacy of the oxime HI-6 alone, using a functional observational battery. Soman-induced neurotoxicity and the neuroprotective effects of HI-6 alone and HI-6 combined with trimedoxime
J. Kassa, J. Karasova, Sandra Tesařová
semanticscholar   +3 more sources

Hydrolysis of acetylthiocholine iodide and reactivation of phoxim-inhibited acetylcholinesterase by pralidoxime chloride, obidoxime chloride and trimedoxime

Archives of Toxicology, 2007
The hydrolysis of acetylthiocholine iodide (ATCh) by pralidoxime chloride (2-PAM Cl), trimedoxime (TMB(4)) and obidoxime chlpride (LUH(6)) was studied at pH 5.8-8.0 and incubation temperature from 5 to 40 degrees C in vitro. Significant ATCh hydrolysis by 2-PAM Cl, TMB(4) and LUH(6) was found, with the exceptions of those at pH 7.0, 6.2 and 5.8 at 5 ...
Yi Zhang, T. Miyata, Z. Wu, Gang Wu, L. Xie   +4 more
semanticscholar   +3 more sources

Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo.

Chemico-Biological Interactions, 2010
Up to now, intensive attempts to synthesize a universal reactivator able to reactivate cholinesterases inhibited by all types of nerve agents/organophosphates were not successful. Therefore, another approach using a combination of two reactivators differently reactivating enzyme was used: in rats poisoned with tabun and treated with combination of ...
J. Bajgar, J. Karasova, J. Kassa, J. Cabal, J. Fusek, V. Bláha, Sandra Tesařová   +6 more
semanticscholar   +3 more sources

Five oximes (K‐27, K‐48, obidoxime, HI‐6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl‐paraoxon

Journal of Applied Toxicology, 2007
AbstractThere is a clear need for broad‐spectrum cholinesterase reactivators (active against a multitude of organophosphorus ester enzyme inhibitors) with a higher efficacy than pralidoxime. The purpose of the study was to quantify in vivo the extent of oxime‐conferred protection, using methyl‐paraoxon [dimethyl p‐nitrophenyl phosphate; (methyl‐POX ...
G. Petroianu, S. Nurulain, N. Nagelkerke, M. Shafiullah, J. Kassa, K. Kuča   +5 more
semanticscholar   +3 more sources

Influence of trimedoxime and atropine on acetylcholinesterase activity in some parts of the brain of mice poisoned by isopropylmethyl phosphonofluoridate.

Biochemical Pharmacology, 1971
F. Bajgar, A. Jakl, V. Hrdina
semanticscholar   +3 more sources

Effects of atropine, trimedoxime and methylprednisolone on the development of organophosphate-induced delayed polyneuropathy in the hen.

Experimental and Toxicologic Pathology, 2001
In this study we have examined the effects of atropine, trimedoxime (TMB-4) and methylprednisolone (MP) on the development of organophosphate-induced delayed polyneuropathy (OPIDP) in the hen. The birds were treated with standard neuropathic dose of diisopropylfluorophosphate (DFP) (1.1 mg/kg, sc), which produced OPIDP that could be graded as 5 on the ...
M. Jokanović, R. M. Stepanović Petrović, M. Maksimović, D. Jovanović, M. Kosanović, V. Piperski   +5 more
semanticscholar   +3 more sources

An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice.

Toxicology, 2008
The potency of newly developed monoxime bispyridinium compounds (K156, K203) in reactivating tabun-inhibited acetylcholinesterase and reducing tabun-induced lethal toxic effects was compared with commonly used oximes (obidoxime, trimedoxime, the oxime HI-6) using in vivo methods.
J. Kassa, J. Karasova, K. Musílek, K. Kuča   +3 more
semanticscholar   +3 more sources