Results 131 to 140 of about 499 (147)
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Toxicology Mechanisms and Methods, 2010
The neuroprotective effects of newly-developed oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) in combination with atropine in rats poisoned with soman were studied. The soman-induced neurotoxicity was monitored using a functional observational battery at 24 h following soman challenge.
J. Kassa +4 more
semanticscholar +3 more sources
The neuroprotective effects of newly-developed oxime K203 and currently available oximes (trimedoxime, obidoxime, HI-6) in combination with atropine in rats poisoned with soman were studied. The soman-induced neurotoxicity was monitored using a functional observational battery at 24 h following soman challenge.
J. Kassa +4 more
semanticscholar +3 more sources
Neurophysiology, 1988
The reactivating and cholinolytic action of trimedoxime bromide was evaluated during experiments on rat soleus and diaphragm muscles accoridng to the amplitude and time course of miniature end-plate potentials and currents (MEPP and MEPC respectively). This agent reactivates acetylcholinesterase (AChE) phosphorylation.
R. A. Giniatullin +3 more
openaire +1 more source
The reactivating and cholinolytic action of trimedoxime bromide was evaluated during experiments on rat soleus and diaphragm muscles accoridng to the amplitude and time course of miniature end-plate potentials and currents (MEPP and MEPC respectively). This agent reactivates acetylcholinesterase (AChE) phosphorylation.
R. A. Giniatullin +3 more
openaire +1 more source
Toxicology Letters, 2006
Abstracts of the EUROTOX 2006/6 CTDC Congress 43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries, 20-24 September 2006, Cavtat ...
Stefanović, D. +5 more
openaire +2 more sources
Abstracts of the EUROTOX 2006/6 CTDC Congress 43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries, 20-24 September 2006, Cavtat ...
Stefanović, D. +5 more
openaire +2 more sources
Drug and Chemical Toxicology, 2008
The potency of newly developed bispyridinium compounds (K117, K127) to reactivate tabun-inhibited acetylcholinesterase and reduce tabun-induced lethal toxic effects was compared with currently available oximes (obidoxime, trimedoxime, oxime HI-6) by using in vivo methods.
J. Kassa +4 more
semanticscholar +4 more sources
The potency of newly developed bispyridinium compounds (K117, K127) to reactivate tabun-inhibited acetylcholinesterase and reduce tabun-induced lethal toxic effects was compared with currently available oximes (obidoxime, trimedoxime, oxime HI-6) by using in vivo methods.
J. Kassa +4 more
semanticscholar +4 more sources
Journal of Toxicology and Environmental Health, Part A, 2006
The efficacy of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate acetylcholinesterase inhibited by two nerve agents (tabun, VX agent) was tested in vitro. Both H oximes (HI-6, HLö-7) and the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase
K. Kuča +4 more
semanticscholar +3 more sources
The efficacy of H oximes (HI-6, HLö-7), the oxime BI-6, and currently used oximes (pralidoxime, obidoxime, trimedoxime) to reactivate acetylcholinesterase inhibited by two nerve agents (tabun, VX agent) was tested in vitro. Both H oximes (HI-6, HLö-7) and the oxime BI-6 were found to be more efficacious reactivators of VX-inhibited acetylcholinesterase
K. Kuča +4 more
semanticscholar +3 more sources
HPLC method for determination of oximes HI-6 and trimedoxime in plasma
1995A high-performance liquid chromatographic (HPLC) assay was developed to determine HI-6 and trimedoxime concentrations in small volumes of plasma. The HPLC system comprised a high-pressure pump (model 2150), a multiwavelenght detector (model 2140) set at 284 nm and 295 nm for detection of trimedoxime and HI-6, respectively, and a sample injector ...
Milić, B +2 more
openaire +1 more source
Bratislavske lekarske listy, 2011
The present experiment is based on biochemical assessment of nerve agent soman intoxication and atropine, respectively atropine and HI-6, trimedoxime or K203 treatment in rats.Nerve agents are toxic substances irreversibly inhibiting enzyme acetylcholinesterase (AChE).
M, Pohanka, J, Pikula, K, Kuca, J, Kassa
openaire +1 more source
The present experiment is based on biochemical assessment of nerve agent soman intoxication and atropine, respectively atropine and HI-6, trimedoxime or K203 treatment in rats.Nerve agents are toxic substances irreversibly inhibiting enzyme acetylcholinesterase (AChE).
M, Pohanka, J, Pikula, K, Kuca, J, Kassa
openaire +1 more source