Results 121 to 130 of about 553,444 (284)

Urolithin A, a Diet‐Derived Gut Microbial Metabolite Against Pulmonary Hypertension Identified via Molecular Docking, Molecular Dynamics and Surface Plasmon Resonance

Food Safety and Health, EarlyView.
Urolithin A, a gut microbial metabolite, binds TNF to suppress proliferation, inflammation, and oxidative stress, offering a promising microbe‐derived therapeutic avenue for pulmonary hypertension. ABSTRACT Pulmonary hypertension (PH) is a complex and multifactorial disease that poses a significant clinical challenge.
Yujie Qu, Yinghua Huo, Yichen Wang, Yao Mu, Xue Yu, Leiyu Tian, Jian Guo, Xuezhi Yang, Yucai Chen   +8 more
wiley   +1 more source

Second‐trimester multimetabolite panel for early preeclampsia rule‐out

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective We aimed to establish a high‐sensitivity, multimetabolite rule‐out model for the development of preeclampsia (PE), prioritizing minimizing false negatives to exclude low‐risk individuals from intensive surveillance confidently. Methods In this prospective, nested case–control study, maternal serum samples were collected between 20+0 ...
Matthews Silva Martins, Julyane N. S. Kaihara, Diego Fortes Salgueiro, Viviane Cunha Cardoso, Silvana Maria Quintana, Ricardo Carvalho Cavalli, Valerio Garrone Barauna, Valeria Cristina Sandrim   +7 more
wiley   +1 more source

Trimethylamine N‐Oxide and Mortality Risk in Patients With Peripheral Artery Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundProduction of the proatherogenic metabolite, trimethylamine N‐oxide (TMAO), from dietary nutrients by intestinal microbiota enhances atherosclerosis development in animal models and is associated with atherosclerotic coronary artery disease in ...
Vichai Senthong, Zeneng Wang, Yiying Fan, Yuping Wu, Stanley L. Hazen, W. H. Wilson Tang   +5 more
doaj   +1 more source

Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study

Nutrition & Metabolism, 2020
Background Accumulating evidence shows that circulating levels of trimethylamine N-oxide, which is generated from the metabolism of dietary choline, may predict cardiovascular disease among Caucasians.
Yuxiang Dai, Qianqian Tian, Jing Si, Zhonghan Sun, Shalaimaiti Shali, Lili Xu, Daoyuan Ren, Shufu Chang, Xin Dong, Hongxia Zhao, Zhendong Mei, Yan Zheng, Junbo Ge   +12 more
doaj   +1 more source

Reduction of trimethylamine N-oxide to trimethylamine by the human gut microbiota: supporting evidence for ‘metabolic retroversion’ [PDF]

, 2015
Dietary sources of methylamines such as choline, trimethylamine (TMA), trimethylamine N-oxide (TMAO), phosphatidylcholine (PC) and carnitine are present in a number of foodstuffs, including meat, fish, nuts and eggs.
Chilloux, J, Dumas, ME, Hoyles, L, Jiménez-Pranteda, ML, McCartney, AL   +4 more
core   +3 more sources

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

iNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang, Yinbo Xu, Yiting Zhao, Liuyi Li, Zhengyi Cheng, Zhongqi Zhang, Yuhang Luo, Qiaoling Liu, Chen Gong, Shichun Shen   +9 more
wiley   +1 more source

Trimethylaminuria [PDF]

, 2007
Viewed on: 14.6.2011Viewed on: 14.6.2011Viewed on: 14.6 ...
Phillips, IR, Shephard, EA
core  

A mechanism for bacterial transformation of dimethylsulfide to dimethylsulfoxide: a missing link in the marine organic sulfur cycle [PDF]

, 2016
The volatile organosulfur compound, dimethylsulfide (DMS), plays an important role in climate regulation and global sulfur biogeochemical cycles. Microbial oxidation of DMS to dimethylsulfoxide (DMSO) represents a major sink of DMS in surface seawater ...
Alfieri, Alonso, Asher, Aylward, Bastet, Boden, Boden, Brimblecombe, Bucciarelli, Buchan, Charlson, Chen, Chen, Cui, Curson, del Valle, del Valle, del Valle, Georg, Gibb, Gibb, Giebel, Gifford, Gilbert, Gilbert, Giovannoni, González, González, González, Green, Hatton, Hatton, Hatton, Hatton, Jonkers, Kiene, Kiene, Krueger, Lee, Lidbury, Lidbury, Lidbury, McDevitt, Miller, Morris, Nelson, Ottesen, Pfreundt, Riseman, Sakurai, Schäfer, Schäfer, Sesto, Simó, Simó, Sjöstedt, Sowell, Stazic, Sun, Sunda, Todd, Tynes, Vila, Vila-Costa, Vila-Costa, Watts, Williams, Williams, Zhu, Zubkov, Zubkov, Zwart   +71 more
core   +1 more source

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

Alzheimer's Research & Therapy, 2018
Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer’s disease (AD), such as metabolic, cardiovascular,
Nicholas M. Vogt, Kymberleigh A. Romano, B. Darst, C. Engelman, Sterling C. Johnson, C. Carlsson, S. Asthana, K. Blennow, H. Zetterberg, B. Bendlin, F. Rey   +10 more
semanticscholar   +1 more source

Macrophage extracellular vesicles deliver Mef2d proteins to aggravate Bacteroides fragilis pathogenicity in type 2 diabetes arterial calcification

Interdisciplinary Medicine, EarlyView.
Bacteroides fragilis is associated with type 2 diabetes (T2D) arterial calcification and can be activated by macrophage‐derived extracellular vesicles (EVs). BF takes up EVs via receptor‐mediated endocytosis, and activation is induced by EV‐derived Mef2d, thereby inhibiting ArsR family transcriptional regulator transcription.
Cong Chen, Rong He, Jirong Luo, Zhengfeng Liang, Qunwen Pan, Shuangquan Liu, Jingsong Cao   +6 more
wiley   +1 more source