Results 121 to 130 of about 19,127 (154)

Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease

Current Atherosclerosis Reports, 2021
The association between plasma Trimethylamine N-Oxide (TMAO), diet and risk for cardiovascular disease (CVD) is still not fully understood. While epidemiologic research shows a causal relationship between plasma TMAO concentrations and CVD risk, the role of dietary precursors in determining plasma concentrations of TMAO and biomarkers for CVD is ...
Minu S. Thomas, Maria Luz Fernandez
openaire   +2 more sources

Microbial Dimethylsulfoxide and Trimethylamine-N-Oxide Respiration

2005
Over the last two decades, the biochemistry and genetics of dimethylsulfoxide (DMSO) and trimethylamine-N-oxide (TMAO) respiration has been characterised, particularly in Escherichia coli marine bacteria of the genus Shewanella and the purple phototrophic bacteria, Rhodobacter sphaeroides and R. capsulatus.
McCrindle, S. L., Kappler, U., McEwan, A. G.   +2 more
openaire   +5 more sources

Trimethylamine N-Oxide in Aquatic Foods

Journal of Agricultural and Food Chemistry
Trimethylamine N-oxide (TMAO), a characteristic nonprotein nitrogen compound, is widely present in seafood, which exhibits osmoregulatory effects for marine organisms in vivo and plays an important role in aquaculture and aquatic product preservation. However, much attention has been focused on the negative effect of TMAO since it has recently emerged ...
Xiaoyue Li, Chengcheng Wang, Teruyoshi Yanagita, Changhu Xue, Tiantian Zhang, Yuming Wang   +5 more
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Trimethylamine N-oxide synthesis: A human variant

Biochemical Medicine, 1972
Abstract A 6-year-old girl exhibiting a variety of clinical symptoms including an apparant inability to metabolize trimethylamine has been shown to possess a defective liver trimethylamine oxidizing system. The defect manifested itself in a Km for trimethylamine which was five times that characteristic of normal enzyme preparation.
T, Higgins, S, Chaykin, K B, Hammond, J R, Humbert   +3 more
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The role of trimethylamine‐N‐Oxide in the development of Alzheimer's disease

Journal of Cellular Physiology, 2021
AbstractAlzheimer's disease is associated with multiple risk factors and is the most common type of dementia. Trimethylamine‐N‐oxide (TMAO), a gut microbiota metabolite derived from dietary choline and carnitine, has recently been identified as a potential risk factor of Alzheimer's disease.
Nida Buawangpong, Kanokporn Pinyopornpanish, Natthapat Siri‐Angkul, Nipon Chattipakorn, Siriporn C. Chattipakorn   +4 more
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The effect of trimethylamine N-oxide on RNase a stability

Journal of Thermal Analysis and Calorimetry, 2007
The thermal stability of bovine pancreatic ribonuclease (RNase A) has been investigated in the presence of trimethylamine N-oxide (TMAO), a naturally occurring osmolyte, by means of differential scanning calorimetry (DSC) and circular dichroism (CD) measurements at neutral and acid pH conditions.
F. FOGLIA, CARULLO, PAOLA, DEL VECCHIO, POMPEA GIUSEPPINA GRAZIA   +2 more
openaire   +4 more sources

Trimethylamine-N-oxide modulates the reductive unfolding of onconase

Biochemical and Biophysical Research Communications, 2004
The physiological osmolyte trimethylamine-N-oxide (TMAO) stabilizes proteins by decreasing the entropy of the unfolded state through a solvophobic effect. Our studies on the effect of TMAO on the reductive unfolding of onconase (ONC) to form its reductive intermediate, des [30-75], indicate that TMAO diminishes the reductive unfolding rate of the ...
Robert F, Gahl, Mahesh, Narayan, Guoqiang, Xu, Harold A, Scheraga   +3 more
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Trimethylamine N-oxidation in Turkish women with bacterial vaginosis

Pharmacogenetics, 1996
Bacterial vaginosis (BV) is the most common cause of vaginal discharge in women of child-bearing age. A common symptom of this condition is a fishy-smelling vaginal discharge. Trimethylamine (TMA) is the substance which is primarily responsible for this distinctive odour.
Green, RL, Mellon, T, Akyol, D, Sardas, S, Cholerton, S, Gokmen, O   +5 more
openaire   +3 more sources

Trimethylamine N-oxide suppresses the activity of the actomyosin motor

Biochimica et Biophysica Acta (BBA) - General Subjects, 2012
During actomyosin interactions, the transduction of energy from ATP hydrolysis to motility seems to occur with the modulation of hydration. Trimethylamine N-oxide (TMAO) perturbs the surface of proteins by altering hydrogen bonding in a manner opposite to that of urea.
Ryusei, Kumemoto, Kento, Yusa, Tomohiro, Shibayama, Kuniyuki, Hatori   +3 more
openaire   +2 more sources

Trimethylamine-N-oxide

Current Opinion in Lipidology, 2016
This article evaluates the link between trimethylamine-N-oxide (TMAO) and bile acids and the consequent impact on the development of atherosclerosis.Elevation in plasma TMAO concentrations is associated with an increased risk of cardiovascular disease in many different patient cohorts.
Aze, Wilson, Cheynne, McLean, Richard B, Kim   +2 more
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