Results 11 to 20 of about 37,079 (207)

Effects of SGLT-2 Inhibitors on Plasma Concentrations and Renal Clearance of the Risk Marker Trimethylamine-N-Oxide in Patients With Type-2 Diabetes. [PDF]

Endocrinol Diabetes Metab
Treatment with empagliflozin or dapagliflozin was associated with a modest increase in plasma concentration of TMAO in Type 2 diabetes patients. These findings suggest a possible class effect of SGLT‐2 inhibitors. Whether this effect impacts the overall clinical benefits of SGLT‐2 inhibitors needs to be subject to further investigation.
Zimmer KB, Gessner A, Kannenkeril D, Bosch A, Ströbel A, Schmieder RE, Maas R.   +6 more
europepmc   +2 more sources

Trimethylamine [PDF]

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Trimethylamine N -oxide is a host–microbial cometabolite that significantly increases following Roux-en-Y gastric bypass. Although trimethylamine N -oxide is associated with cardiovascular diseases, its role in colorectal cancer ...
Yang Bi, Maria Glymenaki, Maria A. Valdivia-Garcia, Mu Wang, Kai Yee Eng, Edward Lin, Nana Gletsu-Miller, Julian R. Marchesi, Ron Smits, Mona El-Bahrawy, Nadia Guerra, Jia V. Li   +11 more
doaj   +2 more sources

Quantification of Trimethylamine-N-Oxide and Trimethylamine in Fish Oils for Human Consumption

Molecules
Supplementing fish oil is one of the strategies to reduce the risk of cardiovascular disease, the leading cause of death around the world. Contradictorily, fish oil may also contain trimethylamine-N-oxide, a recently emerged risk factor for ...
Dominik Dörfel, Sascha Rohn, Eckard Jantzen   +2 more
doaj   +2 more sources

Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
Atherosclerosis (AS) is one of the most common cardiovascular diseases (CVDs), and there is currently no effective drug to reverse its pathogenesis. Trimethylamine N-oxide (TMAO) is a metabolite of the gut flora with the potential to act as a new risk ...
Lele Jing, Honghong Zhang, Qiannan Xiang, Liang Shen, Xiaoxia Guo, Changlin Zhai, Huilin Hu   +6 more
doaj   +1 more source

Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota [PDF]

, 2014
Dietary intake of L-carnitine can promote cardiovascular diseases in humans through microbial production of trimethylamine (TMA) and its subsequent oxidation to trimethylamine N-oxide (TMAO) by hepatic flavin-containing monooxygenases.
Schäfer, Hendrik, Chen, Y.; id_orcid, Jameson, E., Jameson, Eleanor, Cosatti, Marialuisa, Rajakumar, Kumar, Crosatti, M., Bugg, T.D.H., Schäfer, H., Zhu, Yijun, Chen, Yin, Rajakumar, K., Zhu, Y., Bugg, Tim   +13 more
core   +1 more source

Halogen Bonds Formed between Substituted Imidazoliums and N Bases of Varying N-Hybridization

Molecules, 2017
Heterodimers are constructed containing imidazolium and its halogen-substituted derivatives as Lewis acid. N in its sp3, sp2 and sp hybridizations is taken as the electron-donating base.
Steve Scheiner
doaj   +1 more source

Trimethylamine-N-Oxide Pathway: A Potential Target for the Treatment of MAFLD

Frontiers in Molecular Biosciences, 2021
Trimethylamine-N-oxide (TMAO) is a molecular metabolite derived from the gut flora, which has recently emerged as a candidate risk factor for metabolic dysfunction-associated fatty liver disease (MAFLD).
Xun Li, Jia Hong, Yao Wang, Maohua Pei, Luwen Wang, Zuojiong Gong   +5 more
doaj   +1 more source

Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase [PDF]

, 2011
Flavin-containing monooxygenases (FMOs) are one of the most important monooxygenase systems in Eukaryotes and have many important physiological functions. FMOs have also been found in bacteria; however, their physiological function is not known.
Crombie, Andrew, Chen, Y.; id_orcid, Scrivens, James H., Nisha A. Patel, Murrell, J. Colin, Scrivens, J.H., Patel, N.A., J. Colin Murrell, Scrivens, James, Murrell, J. C. (J. Colin), Chen, Yin, James H. Scrivens, Crombie, A., Yin Chen, Patel, Nisha A., Andrew Crombie   +15 more
core   +1 more source

Nanoporous Graphene Oxide-Based Quartz Crystal Microbalance Gas Sensor with Dual-Signal Responses for Trimethylamine Detection

Sensors, 2022
This paper presents a straightforward method to develop a nanoporous graphene oxide (NGO)-functionalized quartz crystal microbalance (QCM) gas sensor for the detection of trimethylamine (TMA), aiming to form a reliable monitoring mechanism strategy for ...
Guangyu Qi, Fangfang Qu, Lu Zhang, Shihao Chen, Mengyuan Bai, Mengjiao Hu, Xinyan Lv, Jinglei Zhang, Zhenhe Wang, Wei Chen   +9 more
doaj   +1 more source

Trimethylamine-N-oxide is an independent risk factor for hospitalization events in patients receiving maintenance hemodialysis

Renal Failure, 2020
Background Hospitalization is a significant outcome measurement for maintenance hemodialysis pantients. Trimethylamine-N-oxide (TMAO), created by gut microflora from dietary l-carnitine and choline, cleared by the kidney, has been implicated in the ...
Yin Zheng, Zihui Tang, Li You, Yuanhao Wu, Junfeng Liu, Jun Xue   +5 more
doaj   +1 more source