Results 1 to 10 of about 437,611 (231)

Gut microbiota dependant trimethylamine N-oxide and hypertension

Frontiers in Physiology, 2023
The human gut microbiota environment is constantly changing and some specific changes influence the host’s metabolic, immune, and neuroendocrine functions.
Katongo H. Mutengo, Katongo H. Mutengo, Sepiso K. Masenga, Sepiso K. Masenga, Aggrey Mweemba, Wilbroad Mutale, Annet Kirabo   +6 more
doaj   +4 more sources

Role of Trimethylamine N-Oxide in Heart Failure

Reviews in Cardiovascular Medicine
Heart failure (HF) is a clinical syndrome characterizing by typical physical signs and symptomatology resulting from reduced cardiac output and/or intracardiac pressure at rest or under stress due to structural and/or functional abnormalities of the ...
Lele Jing, Honghong Zhang, Qiannan Xiang, Huilin Hu, Changlin Zhai, Suining Xu, Hongen Tian   +6 more
doaj   +4 more sources

Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide

Microbiome, 2021
Background Communication between the gut microbiota and the brain is primarily mediated via soluble microbe-derived metabolites, but the details of this pathway remain poorly defined. Methylamines produced by microbial metabolism of dietary choline and l-
Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodriguez-Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L. Carvalho, Simon R. Carding, Michael Müller, Robert C. Glen, David Vauzour, Simon McArthur   +13 more
doaj   +2 more sources

The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

Frontiers in Endocrinology, 2023
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide. Researchers have found that the occurrence and development of CVDs are closely related to intestinal microecology.
Jing Zhen, Jing Zhen, Zhou Zhou, Meng He, Hai-Xiang Han, En-Hui Lv, Peng-Bo Wen, Xin Liu, Yan-Ting Wang, Xun-Chao Cai, Jia-Qi Tian, Meng-Ying Zhang, Lei Xiao, Xing-Xing Kang   +13 more
doaj   +2 more sources

Trimethylamine N-oxide (TMAO) in human health

EXCLI journal, 2021
Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and diseases, this topic is very popular and is often taken up by researchers. TMAO is a low molecular weight compound that belongs to the class of amine oxides.
Paulina Gątarek, J. Kałużna-Czaplińska   +1 more
semanticscholar   +3 more sources

Trimethylamine N-oxide in atrial fibrillation progression

International Journal of Cardiology: Heart & Vasculature, 2020
The human gut microbiome and its metabolite Trimethylamine N-oxide (TMAO) are sensitive to the human diet and are involved in the complex pathomechanisms that underpin diabetes, obesity, and cardiovascular diseases.
Petra Büttner, Jürgen G. Okun, Jana Hauke, Erik Holzwirth, Danilo Obradovic, Gerhard Hindricks, Holger Thiele, Jelena Kornej   +7 more
doaj   +3 more sources

Trimethylamine N-oxide impairs β-cell function and glucose tolerance

Nature Communications
β-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we found that trimethylamine N-oxide (TMAO) at a similar concentration to that found in diabetes could directly decrease glucose-stimulated insulin secretion (GSIS) in MIN6 ...
Lijuan Kong, Qijin Zhao, Xiaojing Jiang, Jinping Hu, Qian Jiang, Li Sheng, Xiaohong Peng, Shusen Wang, Yibing Chen, Yanjun Wan, Shaocong Hou, Xingfeng Liu, Chunxiao Ma, Yan Li, Li Quan, Liangyi Chen, Bing Cui, Pingping Li   +17 more
doaj   +2 more sources

Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health. [PDF]

Metabolites
The intestinal microbiota, hosting trillions of microorganisms that inhabit the gastrointestinal tract, functions as a symbiotic organism that plays a crucial role in regulating health by producing biologically active molecules that can enter systemic ...
Caradonna E, Abate F, Schiano E, Paparella F, Ferrara F, Vanoli E, Difruscolo R, Goffredo VM, Amato B, Setacci C, Setacci F, Novellino E.   +11 more
europepmc   +2 more sources

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota [PDF]

Microbiome, 2018
Background The dietary methylamines choline, carnitine, and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA).
Lesley Hoyles, Maria L. Jiménez-Pranteda, Julien Chilloux, Francois Brial, Antonis Myridakis, Thomas Aranias, Christophe Magnan, Glenn R. Gibson, Jeremy D. Sanderson, Jeremy K. Nicholson, Dominique Gauguier, Anne L. McCartney, Marc-Emmanuel Dumas   +12 more
doaj   +2 more sources

The microbial metabolite trimethylamine N-oxide and the kidney diseases [PDF]

Frontiers in Cellular and Infection Microbiology
Trimethylamine N-oxide (TMAO), a metabolite, is a co-metabolite produced by both gut microbiota and livers, originating from foods rich in choline or carnitine.
Jin-Qi Su, Jin-Qi Su, Xiang-Qi Wu, Xiang-Qi Wu, Qi Wang, Qi Wang, Bo-Yang Xie, Bo-Yang Xie, Cui-Yan Xiao, Cui-Yan Xiao, Hong-Yong Su, Hong-Yong Su, Ji-Xin Tang, Ji-Xin Tang, Cui-Wei Yao, Cui-Wei Yao   +15 more
doaj   +2 more sources