Results 41 to 50 of about 561,219 (291)

Influence of Trimethylamine N-Oxide on Platelet Activation

Nutrients, 2022
Microbiome-derived trimethylamine N-oxide (TMAO) has been associated with platelet hyperreactivity and subsequent atherogenesis. Whether physiological TMAO-levels influence platelet-derived lipid mediators remains unknown. Little is known about pre-analytic factors potentially influencing TMAO concentrations. We aimed at developing a quantitative LC-MS/
Emonds, Julian Josef, Ringel, Clemens, Reinicke, Madlen, Müller, Daniel, Von Eckardstein, Arnold, Meixensberger, Jürgen, Ceglarek, Uta, Gaudl, Alexander   +7 more
openaire   +3 more sources

Role of gut microbiota-generated short chain fatty acids in metabolic and cardiovascular health [PDF]

, 2018
Purpose of this Review: This review assesses the latest evidence linking short-chain fatty acids (SCFA) with host metabolic health and cardiovascular disease (CVD) risk and presents the latest evidence on possible biological mechanisms.
Chambers, Edward S., Frost, Gary, Morrison, Douglas J., Preston, Tom   +3 more
core   +1 more source

Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet [PDF]

, 2017
Gut microbiota is emerging as a novel risk factor for atherothrombosis, but the predictive role of gut-derived lipopolysaccharide (LPS) is unknown. We analyzed (1) the association between LPS and major adverse cardiovascular events (MACE) in atrial ...
Cammisotto, Vittoria, Carnevale, Roberto, Menichelli, Danilo, Nocella, Cristina, Novo, Marta, Pastori, Daniele, Pignatelli, Pasquale, Santulli, Maria, Violi, Francesco   +8 more
core   +1 more source

High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

Science, 2021
Gut bugs and systemic disease risk What people eat has an immediate selective effect on the microbial populations resident in the gut. A high-fat diet is associated with the occurrence of microbes that catabolize choline and the accumulation of ...
Woongjae Yoo, Jacob K. Zieba, N. J. Foegeding, Teresa P. Torres, Catherine D. Shelton, Nicolas G. Shealy, Austin J Byndloss, Stephanie A. Cevallos, E. Gertz, Connor R. Tiffany, Julia D. Thomas, Yael Litvak, Henry Nguyen, Erin E. Olsan, Brian J. Bennett, J. Rathmell, A. Major, A. Bäumler, M. Byndloss   +18 more
semanticscholar   +1 more source

Comparative genomics and mutagenesis analyses of choline metabolism in the marine Roseobacter clade [PDF]

, 2015
Choline is ubiquitous in marine eukaryotes and appears to be widely distributed in surface marine waters; however, its metabolism by marine bacteria is poorly understood.
Andresen P.A., Gauthier M.J., Ghoul M., Ikawa M., Kiene R.P., Nau‐Wagner G., Prado S.   +6 more
core   +1 more source

Advances in BODIPY Derivatives for Antibacterial Phototherapy

Angewandte Chemie, EarlyView.
This review systematically summarizes the design strategies and structure‐activity relationships of BODIPY‐based antibacterial phototherapy, covering molecular engineering of small‐molecule photosensitizers and nanoplatforms, bacterial targeting and carrier design, and discussing the challenges and future perspectives associated with clinical ...
Li Lv, Heejeong Kim, Hongchen Zhai, Hanqi Ren, Silu Wang, Cong Sun, Yafu Wang, Hosoowi Lee, Juyoung Yoon, Hua Zhang   +9 more
wiley   +2 more sources

Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

mBio, 2016
The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) is a natural phytoalexin with anti-AS effects; however, its mechanisms of action remain unclear.
Ming‐liang Chen, Long Yi, Yong Zhang, Xi Zhou, Li Ran, Jining Yang, Jun‐dong Zhu, Qian‐yong Zhang, M. Mi   +8 more
semanticscholar   +1 more source

Seasonal changes in microbial dissolved organic sulfur transformations in coastal waters [PDF]

, 2020
The marine trace gas dimethylsulfide (DMS) is the single most important biogenic source of atmospheric sulfur, accounting for up to 80% of global biogenic sulfur emissions.
Dixon, Joanna L., Hopkins, Frances E., Schäfer, Hendrik, Stephens, John A.   +3 more
core   +1 more source

Untargeted lipidomic features associated with colorectal cancer in a prospective cohort. [PDF]

, 2018
BackgroundEpidemiologists are beginning to employ metabolomics and lipidomics with archived blood from incident cases and controls to discover causes of cancer.
Cai, Xiaoming, Dudoit, Sandrine, Edmands, William MB, Grigoryan, Hasmik, Gunter, Marc J, Naccarati, Alessio, Perttula, Kelsi, Petrick, Lauren, Polidoro, Silvia, Rappaport, Stephen M, Schiffman, Courtney, Vineis, Paolo   +11 more
core   +3 more sources

Quantification of Trimethylamine-N-Oxide and Trimethylamine in Fish Oils for Human Consumption

Molecules
Supplementing fish oil is one of the strategies to reduce the risk of cardiovascular disease, the leading cause of death around the world. Contradictorily, fish oil may also contain trimethylamine-N-oxide, a recently emerged risk factor for ...
Dominik Dörfel, Sascha Rohn, Eckard Jantzen   +2 more
doaj   +1 more source