Results 61 to 70 of about 14,468,554 (196)

Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients [PDF]

Journal of the American Society of Nephrology, 2016
Cardiovascular disease causes over 50% of the deaths in dialysis patients, and the risk of death is higher in white than in black patients. The underlying mechanisms for these findings are unknown. We determined the association of the proatherogenic metabolite trimethylamine N -oxide (TMAO ...
Tariq, Shafi, Neil R, Powe, Timothy W, Meyer, Seungyoung, Hwang, Xin, Hai, Michal L, Melamed, Tanushree, Banerjee, Josef, Coresh, Thomas H, Hostetter   +8 more
openaire   +2 more sources

Literature search and study selection process for inclusion in meta-analysis of trimethylamine-N-oxide (TMAO) and the risk of acute ischemic stroke (AIS).

, 2023
Literature search and study selection process for inclusion in meta-analysis of trimethylamine-N-oxide (TMAO) and the risk of acute ischemic stroke (AIS).
Nianqiu Liu (17290684), Qiuyue Xu (8931536), Ya Li (194567), Zaidie Sun (17290681), Kai Yang (73590), Yong Duan (151342), Yuan Hong (413401), Zhangyou Guo (15444468)   +7 more
core   +1 more source

A review on the beneficial and detrimental roles of gut microbiota-derived trimethylamine-N-oxide (TMAO)

Infectious Medicine
In recent years, increasing attention has focused on the role of the gut microbiome in converting dietary substances into bioactive metabolites implicated in the etiology of various diseases.
Erta Rajabi, Zahra Pourramezan Seyedi, Mahsa Ghamari, Roghayeh Mohammadzadeh, Mehdi Mansouri, Friedrich Götz, Narjess Bostanghadiri   +6 more
doaj   +1 more source

Trimethylamine N-Oxide and Related Metabolites in the Serum and Risk of Type 2 Diabetes in the Chinese Population: A Case-Control Study

Diabetes, Metabolic Syndrome and Obesity, 2023
Shenghong Qi,1,2 Lan Liu,1,2 Shulan He,1,2 Liqun Wang,1,2 Jiangping Li,1,2 Xian Sun1,2 1School of Public Health and Management, Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2The Key Laboratory of Environmental Factors and ...
Qi S, Liu L, He S, Wang L, Li J, Sun X
doaj  

Trimethylamine-N-Oxide Instigates NLRP3 Inflammasome Activation and Endothelial Dysfunction

Cellular Physiology and Biochemistry, 2017
Background/Aim: Plasma trimethylamine-N-oxide (TMAO), a product of intestinal microbial metabolism of dietary phosphatidylcholine has been recently associated with atherosclerosis and increased risk of cardiovascular diseases (CVD) in rodents and humans.
Krishna M. Boini, Tahir Hussain, Pin-Lan Li, Sai S Koka   +3 more
doaj   +1 more source

The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial. [PDF]

PLoS ONE, 2016
UNLABELLED:The colonic microbial metabolism is a key contributor to uremic retention solutes accumulating in patients with CKD, relating to adverse outcomes and insulin resistance.
Ruben Poesen, Pieter Evenepoel, Henriette de Loor, Jan A Delcour, Christophe M Courtin, Dirk Kuypers, Patrick Augustijns, Kristin Verbeke, Björn Meijers   +8 more
doaj   +1 more source

Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease [PDF]

, 2016
Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in the metabolism of therapeutic drugs. However, on a daily basis we are exposed to one of the most abundant substrates of the enzyme, trimethylamine, which is released ...
Phillips, IR, Shephard, EA, Fennema, D
core  

Advanced In Vitro Platforms for Experimental Liver Research: From Organoids and Liver‐on‐Chip to Omics and Artificial Intelligence

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Hepatocytes perform essential physiological functions in the human body. Gaining more profound insight into the liver structure, diseases, and physiology by using in vitro models can help to propose more relevant clinical applications. Conventional in vitro liver models, such as two‐dimensional (2D) cell cultures, fail to adequately replicate ...
Seyedeh Kiana Teymorian, Pedram Asadi Sarabi, Abbas Piryaei, Massoud Vosough   +3 more
wiley   +1 more source

Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase

eLife
Substrate channeling enhances efficiency and prevents toxicity by directing unstable intermediates between active sites. Trimethylamine N-oxide demethylase (TDM) degrades trimethylamine N-oxide (TMAO) to dimethylamine and formaldehyde (HCHO), but the ...
Trung Thach, KanagaVijayan Dhanabalan, Shiwangi Maurya, Yu Han-Hallett, Senwei Quan, Jane Allison, Gurunath Ramanathan, Ramaswamy Subramanian   +7 more
doaj   +1 more source

Molybdenum‐carbothioamide complexes as potential single‐source precursors for MoS2 thin film

Bulletin of the Korean Chemical Society, EarlyView.
Novel molybdenum complexes were synthesized to apply for deposition of Mo‐containing thin films. All complexes were characterized, and they are likely to be used as single‐source precursors for MoS2 thin films. Abstract Molybdenum disulfide (MoS2) thin films are widely used in batteries, transistors, supercapacitors, and 2D materials owing to their ...
Sung Kwang Lee, Dagyum Yoo, Tae Wook Kim, Taek‐Mo Chung   +3 more
wiley   +1 more source