Results 81 to 90 of about 14,468,554 (196)

Trimethylamine-N-oxide is an independent risk factor for hospitalization events in patients receiving maintenance hemodialysis

Renal Failure, 2020
Background Hospitalization is a significant outcome measurement for maintenance hemodialysis pantients. Trimethylamine-N-oxide (TMAO), created by gut microflora from dietary l-carnitine and choline, cleared by the kidney, has been implicated in the ...
Yin Zheng, Zihui Tang, Li You, Yuanhao Wu, Junfeng Liu, Jun Xue   +5 more
doaj   +1 more source

Restored mutant receptor:Corticoid binding in chaperone complexes by trimethylamine N-oxide. [PDF]

PLoS ONE, 2017
Without a glucocorticoid (GC) ligand, the transcription factor glucocorticoid receptor (GR) is largely cytoplasmic, with its GC-binding domain held in high affinity conformation by a cluster of chaperones.
Aaron L Miller, W Austin Elam, Betty H Johnson, Shagufta H Khan, Raj Kumar, E Brad Thompson   +5 more
doaj   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Pressing the trimethylamine N-oxide narrative

AME Medical Journal, 2017
We read with interest the correspondence titled “Gut Microbe-Generated Trimethylamine N-Oxide from Dietary Choline is Prothrombotic in Subjects”, published by Zhu et al . in the journal Circulation (1). This work builds on an emerging body of evidence which has suggested a role for the gut-derived metabolite, trimethylamine N -oxide (TMAO), in the ...
Kevin C. Klatt, Marie A. Caudill
openaire   +1 more source

Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase [PDF]

, 2011
Flavin-containing monooxygenases (FMOs) are one of the most important monooxygenase systems in Eukaryotes and have many important physiological functions. FMOs have also been found in bacteria; however, their physiological function is not known.
Crombie, Andrew, Chen, Y.; id_orcid, Scrivens, James H., Nisha A. Patel, Murrell, J. Colin, Scrivens, J.H., Patel, N.A., J. Colin Murrell, Scrivens, James, Murrell, J. C. (J. Colin), Chen, Yin, James H. Scrivens, Crombie, A., Yin Chen, Patel, Nisha A., Andrew Crombie   +15 more
core   +1 more source

Trimethylamine N-oxide: heart of the microbiota–CVD nexus? [PDF]

, 2020
We critically review potential involvement of trimethylamine-N-oxide (TMAO) as a link between diet, the gut microbiota and cardiovascular disease (CVD).
Du Toit, EF, Cox, AJ, Peart, JN, Headrick, JP, Naghipour, S   +4 more
core   +1 more source

Body‐integrated photonic biosensors: Illuminating the path to active healthcare

FlexMat, EarlyView.
Body‐integrated photonic biosensors are promising tools for active healthcare. These optical devices can be worn, implanted, or swallowed to monitor health signals continuously. This review introduces key sensing modalities, including fluorescence, colorimetry, SPR, LSPR, SERS, and light‐modulating materials.
Jiayue Gu, Xingming Wen, Qihang Yan, Yining Zhao, Linghao Yuan, Siyuan Chen, Yue Ma, Zhengyue Fang, Dong Lei, Yuxin Liu, Ze Xiong   +10 more
wiley   +1 more source

Syncing Health Timing: Exploring the Interplay of Circadian Rhythms, Obesity, and Cardiovascular Diseases

Food Safety and Health, EarlyView.
Circadian rhythm disruption impairs metabolic regulation, appetite control, and vascular function, promoting obesity and cardiovascular diseases. Evidence highlights a bidirectional relationship where metabolic disorders further disturb circadian timing.
Ghizal Fatima, István Dalmadi, Anna Jánosi, Krisztina Takács, Eszter Halmy   +4 more
wiley   +1 more source

Biosensors for Food Safety and Adulteration Monitoring: Applications, Smart Packaging Integration, and Pathways to Intelligent, Field‐Deployable Detection Systems

Food Safety and Health, EarlyView.
Biosensors enable rapid, sensitive, and portable detection of pathogens, contaminants, allergens, and food adulteration. Integration with smart packaging, smartphones, IoT, and machine learning supports real‐time monitoring and intelligent decision‐making, whereas microfluidics, biodegradable materials, explainable AI, and blockchain offer pathways ...
Mohima Akther Any, Abid Hassan Arnab, Liza Akter, Yusuf Chowdhury, Md. Hassan Bin Nabi, Md Abu Rayhan, Nazmul Islam, Wahidu Zzaman   +7 more
wiley   +1 more source

The food-derived metabolite trimethylamine and trimethylamine-N-oxide promote colorectal cancer progression via SREBF1

Ecotoxicology and Environmental Safety
Colorectal cancer (CRC) is characterised by microbial dysbiosis. Trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) are gut microbiota-derived metabolites produced from dietary precursors that are implicated in CRC progression.
Yang Yan, Jiaxuan Li, Hejia Xu, Chen Yang, Guifang Li, Yanyan Feng, Qian Wang, Li Li, Rendi Wu, Hairong Sun, Ting Zhang, Fang Wang, Yong Mao   +12 more
doaj   +1 more source