Results 81 to 90 of about 33,642 (251)
Reduction of trimethylamine N-oxide to trimethylamine by the human gut microbiota: supporting evidence for ‘metabolic retroversion’ [PDF]
, 2015 Dietary sources of methylamines such as choline, trimethylamine (TMA), trimethylamine N-oxide (TMAO), phosphatidylcholine (PC) and carnitine are present in a number of foodstuffs, including meat, fish, nuts and eggs.
Chilloux, J +4 more
core +3 more sources
Trimethylamine N-Oxide: The Good, the Bad and the Unknown
Toxins, 2016 Trimethylamine N-oxide (TMAO) is a small colorless amine oxide generated from choline, betaine, and carnitine by gut microbial metabolism. It accumulates in the tissue of marine animals in high concentrations and protects against the protein ...
Manuel T. Velasquez +3 more
doaj +1 more source
Renal Failure, 2020 Background Hospitalization is a significant outcome measurement for maintenance hemodialysis pantients. Trimethylamine-N-oxide (TMAO), created by gut microflora from dietary l-carnitine and choline, cleared by the kidney, has been implicated in the ...
Yin Zheng +5 more
doaj +1 more source
Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding [PDF]
, 2010 Transmissible spongiform encephalopathies, or prion diseases, are caused by misfolding and aggregation of the prion protein PrP. These diseases can be hereditary in humans and four of the many disease-associated missense mutants of PrP are in the ...
Daggett, Valerie, van der Kamp, Marc W
core +2 more sources
European Journal of Inorganic Chemistry, EarlyView.The concept of scorpionate ligands has evolved significantly since the introduction of tris(pyrazolyl)borate. By integrating a biological supramolecular ligand scaffold with the classic scorpionate architecture, researchers have made notable strides in mimicking the active sites of nitrogenase and advancing homogeneous catalysis.
Austin Winfield Medley +1 more
wiley +1 more source
Microbial trimethylamine metabolism in marine environments [PDF]
, 2019 Trimethylamine (TMA) is common in marine environments. Although the presence of this compound in the oceans has been known for a long time, unlike the mammalian gastrointestinal tract, where TMA metabolism by microorganisms has been studied intensely ...
Chen, Yin +3 more
core +1 more source
From Phosphinimines to Four‐Membered SiCPN Cations: Insights Into N–Si Bonding and Ring Strain
European Journal of Inorganic Chemistry, EarlyView.Sterically tuned N‐silyl phosphinimines enable four‐membered SiCPN cations. Hydride abstraction yields cyclic cations for Me and iPr substituents at silicon, while tBu gives a protonated intermediate. Multinuclear NMR spectroscopy, X‐ray crystallography, thermochemical density functional theory investigations, and natural bond orbital analyses reveal ...
Alexander Falk, Jonathan O. Bauer
wiley +1 more source
Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure (from BIOSTAT-CHF) [PDF]
, 2018 Aims: Association of elevated circulating levels of trimethylamine N-oxide (TMAO) with adverse outcomes in patients with heart failure (HF) has been described.
Anker, Stefan D. +17 more
core +4 more sources
Emerging Trends in Organic Photoreactions Utilizing Disulfides
European Journal of Organic Chemistry, EarlyView.Disulfides are versatile, nontoxic alternatives to metal photocatalysts. This review explores their role as photoactivated thiyl‐radical precursors and bifunctional catalysts (HAT/electron shuttling) in diverse transformations. Strategies for electronic tuning and development into recyclable heterogeneous materials are highlighted for sustainable ...
Sunil Kumar +3 more
wiley +1 more source
Metagenomic data-mining reveals contrasting microbial populations responsible for trimethylamine formation in human gut and marine ecosystems [PDF]
, 2016 Existing metagenome datasets from many different environments contain untapped potential for understanding metabolic pathways and their biological impact.
Airs, Ruth +5 more
core +1 more source