Results 91 to 100 of about 561,219 (291)

Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
Atherosclerosis (AS) is one of the most common cardiovascular diseases (CVDs), and there is currently no effective drug to reverse its pathogenesis. Trimethylamine N-oxide (TMAO) is a metabolite of the gut flora with the potential to act as a new risk ...
Lele Jing, Honghong Zhang, Qiannan Xiang, Liang Shen, Xiaoxia Guo, Changlin Zhai, Huilin Hu   +6 more
doaj   +1 more source

Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases

Biomedicines, 2023
Trimethylamine N-oxide (TMAO) is a metabolite produced by the gut microbiota and has been mainly associated with an increased incidence of cardiovascular diseases (CVDs) in humans. There are factors that affect one’s TMAO level, such as diet, drugs, age,

semanticscholar   +1 more source

Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model [PDF]

, 2008
The transgenomic metabolic effects of exposure to either Lactobacillus paracasei or Lactobacillus rhamnosus probiotics have been measured and mapped in humanized extended genome mice (germ-free mice colonized with human baby flora).
Allison C, Blum S, Cummings JH, Donaldson RM, Elaine Holmes, Fan TW, Francois‐Pierre J Martin, Fuller R, Ikram‐ul H, Ivan K S Yap, Jeremy K Nicholson, John C Lindon, Laurent B Fay, Macfarlane GT, Norbert Sprenger, Per Lek, Peter van Bladeren, Serge Rezzi, Sunil Kochhar, Torbjörn Lundstedt, Yulan Wang, Zeisel SH, Ziad Ramadan   +22 more
core   +2 more sources

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Research advances of trimethylamine N-oxide and chronic kidney diseases

Linchuang shenzangbing zazhi, 2021
Trimethylamine N-oxide（TMAO）is an important gut microbiota-dependent metabolite.Currently many clinical studies have confirmed the correlation between TMAO and the prognosis of chronic kidney disease（CKD）patients.This review summarized the latest ...
Liu Mei-jun, Zhou Wen-hua, Zhao Jing, Cui Wen-Peng   +3 more
doaj  

The roles of trimethylamine-N-oxide in atherosclerosis and its potential therapeutic aspect: A literature review

Biomolecules & biomedicine, 2023
Current research supports the evidence that the gut microbiome (GM), which consists of gut microbiota and their biologically active metabolites, is associated with atherosclerosis development.
Y. Oktaviono, Ariikah Dyah Lamara, P. B. T. Saputra, J. Arnindita, D. Pasahari, M. E. Saputra, Ni Made Adnya Suasti   +6 more
semanticscholar   +1 more source

Assessing hepatic metabolic changes during progressive colonization of germ-free mouse by 1H NMR spectroscopy [PDF]

, 2011
It is well known that gut bacteria contribute significantly to the host homeostasis, providing a range of benefits such as immune protection and vitamin synthesis.
Claus, Sandrine, Heath, Peter
core   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

Chronic Diseases and Translational Medicine, EarlyView.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian, Dan Nie, Qianyi Gao, Xingbo Mo, Huan Zhang   +4 more
wiley   +1 more source

The Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies

Clinical Interventions in Aging, 2021
Rui Huang,1,* Li Yan,2,* Yuhua Lei1 1Cardiovascular Disease Center, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi Prefecture, 445000, Hubei Province, People’s Republic of China ...
Huang R, Yan L, Lei Y
doaj  

Dye modification of nanofibrous silicon oxide membranes for colorimetric HCl and NH3 sensing [PDF]

, 2016
Colorimetric sensors for monitoring and visual reporting of acidic environments both in water and air are highly valuable in various fields, such as safety and technical textiles.
Breyne, Bet, Cousins, Gabriella, De Buysser, Klaartje, De Clerck, Karen, Geltmeyer, Jozefien, Hoogenboom, Richard, Lava, Kathleen, Steyaert, Iline, Vancoillie, Gertjan   +8 more
core   +1 more source