Results 71 to 80 of about 561,219 (291)

Gut microbiota-derived trimethylamine N-Oxide: a novel target for the treatment of preeclampsia

Gut microbes
Pre-eclampsia (PE) is the most common complication of pregnancy and seriously threatens the health and safety of the mother and child. Studies have shown that an imbalance in gut microbiota can affect the progression of PE.
Jiayi Wang, Yajie Gao, Shuaijun Ren, Jialin Li, Siqian Chen, Jiating Feng, Bing He, Yuping Zhou, Rongrong Xuan   +8 more
semanticscholar   +1 more source

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
The choline‐derived metabolite trimethylamine N‐oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk.
M. Seldin, Yonghong Meng, Hongxiu Qi, Weifei Zhu, Zeneng Wang, S. Hazen, A. Lusis, D. Shih   +7 more
semanticscholar   +1 more source

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]

, 2018
Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter, Johnson, Richard J., Kuro-o, Makoto, Lanaspa, Miguel, Painer, Johanna, Ruf, Thomas, Shiels, Paul G., Stenvinkel, Peter   +7 more
core   +1 more source

Association of diet with circulating trimethylamine-N-oxide concentration [PDF]

The American Journal of Clinical Nutrition, 2020
Trimethylamine-N-oxide (TMAO) is a compound that is present in seafood and produced through human gut microbial metabolism of its precursors. Previous studies have suggested that elevated TMAO concentrations are associated with an increased risk of cardiovascular events. However, the association between diet and TMAO concentrations in free-living adult
Rikuta Hamaya, Kerry L Ivey, Dong H Lee, Molin Wang, Jun Li, Adrian Franke, Qi Sun, Eric B Rimm   +7 more
openaire   +2 more sources

Nanocurvature‐Activated Dipolar Polarization in M–N4 Single‐Atom Sites for High‐Performance Electromagnetic Wave Absorption

Advanced Science, EarlyView.
Increasing nanocurvature effectively enriches the local electron density of the M–N4 motif, which facilitates electron transfer from the metal center to nitrogen atoms. This electronic behavior intensifies the localization and asymmetric distribution of charge, thereby significantly amplifying the dipole moment and polarizability.
Daohu Sheng, Siyao Cheng, Mengmeng Zhang, Jinglei Zhang, Xufei Zhu, Weijin Li, Bo Zhang, Aming Xie   +7 more
wiley   +1 more source

Gut microbiota metabolite trimethylamine N-oxide promoted NAFLD progression by exacerbating intestinal barrier disruption and intrahepatic cellular imbalance.

International Immunopharmacology
Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide, with the gut microbiota and its metabolites are important regulators of its progression.
Fulin Nian, Yueying Chen, Qiaoyun Xia, Chen Zhu, Longyun Wu, Xiaolan Lu   +5 more
semanticscholar   +1 more source

Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation

Cell Metabolism, 2013
SUMMARY Circulating trimethylamine-N-oxide (TMAO) levels are strongly associated with atherosclerosis. We now examine genetic, dietary, and hormonal factors regulating TMAO levels.
Brian J. Bennett, T. Q. de Aguiar Vallim, Zeneng Wang, D. Shih, Yonghong Meng, J. Gregory, H. Allayee, Richard G. Lee, M. Graham, R. Crooke, P. Edwards, S. Hazen, A. Lusis   +12 more
semanticscholar   +1 more source

A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-MEAT).

American Journal of Clinical Nutrition, 2020
BACKGROUND Despite the rising popularity of plant-based alternative meats, there is limited evidence of the health effects of these products. OBJECTIVES We aimed to compare the effect of consuming plant-based alternative meat (Plant) as opposed to ...
Anthony Crimarco, Sparkle Springfield, Christina I. Petlura, Taylor Streaty, K. Cunanan, Justin Lee, Priya Fielding‐Singh, M. M. Carter, Madeline A. Topf, H. Wastyk, E. Sonnenburg, J. Sonnenburg, C. Gardner   +12 more
semanticscholar   +1 more source

The Role of the Gut Microbiota in Allogeneic Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Allogeneic hematopoietic cell transplantation (allo‐HCT) is an effective treatment for patients with high‐risk hematologic malignancies. Over the last decade, gut microbiota composition during allo‐HCT has been associated with patients' outcomes.
Wenjing Hao, Nicolas Stocker, Béatrice Gaugler, Mohamad Mohty, Florent Malard   +4 more
wiley   +1 more source

Gut‒heart axis: emerging therapies targeting trimethylamine N-oxide production

Gut Microbes
Trimethylamine N-oxide (TMAO) has garnered considerable attention because of its role in the pathophysiology and pathogenesis of various disorders, particularly heart and kidney disease.
Efrain Ricardo Torres, Jennifer Wilcox, W. H. Wilson Tang   +2 more
doaj   +1 more source