Results 51 to 60 of about 561,219 (291)

Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health

Metabolites
The intestinal microbiota, hosting trillions of microorganisms that inhabit the gastrointestinal tract, functions as a symbiotic organism that plays a crucial role in regulating health by producing biologically active molecules that can enter systemic ...
E. Caradonna, Federico Abate, Elisabetta Schiano, Francesca Paparella, F. Ferrara, Emilio Vanoli, Rossana Difruscolo, Vito Maria Goffredo, Bruno Amato, Carlo Setacci, F. Setacci, Ettore Novellino   +11 more
semanticscholar   +1 more source

Intestinal Microbiota Metabolism and Atherosclerosis

Chinese Medical Journal, 2015
Objective: This review aimed to summarize the relationship between intestinal microbiota metabolism and cardiovascular disease (CVD) and to propose a novel CVD therapeutic target.
Tian-Xing Liu, Hai-Tao Niu, Shu-Yang Zhang   +2 more
doaj   +1 more source

The Role of Gut Microbiota-Derived Trimethylamine N-Oxide in the Pathogenesis and Treatment of Mild Cognitive Impairment

International Journal of Molecular Sciences
Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia, often considered critical for dementia prevention. Despite its significance, no effective clinical treatment for MCI has yet been established.
Haihua Xie, Jia Jiang, Sihui Cao, Xuan Xu, Jingying Zhou, Ruhan Zhang, Bo Huang, Penghui Lu, Liang Peng, Mi Liu   +9 more
semanticscholar   +1 more source

Flavoprotein monooxygenases for oxidative biocatalysis: recombinant expression in microbial hosts and applications [PDF]

, 2014
External flavoprotein monooxygenases comprise a group of flavin-dependent oxidoreductases that catalyze the insertion of one atom of molecular oxygen into an organic substrate and the second atom is reduced to water. These enzymes are involved in a great
Bianchi, Dario Alejandro, Ceccoli, Romina Denis, Rial, Daniela Veronica   +2 more
core   +2 more sources

TMAO metaorganismal pathway and chronic inflammatory diseases [PDF]

Exploration of Medicine
Nutrients containing a trimethylamine (TMA) moiety in their structure can be metabolized by the gut microbiota through enzymatic cleavage of the C-N bond, producing TMA.
Zeneng Wang, Shumei Man, Robert Koeth
doaj   +1 more source

Analysis of metabolomic patterns in thoroughbreds before and after exercise [PDF]

Asian-Australasian Journal of Animal Sciences, 2017
Objective Evaluation of exercise effects in racehorses is important in horseracing industry and animal health care. In this study, we compared metabolic patterns between before and after exercise to screen metabolic biomarkers for exercise effects in ...
Hyun-Jun Jang, Duk-Moon Kim, Kyu-Bong Kim, Jeong-Woong Park, Jae-Young Choi, Jin Hyeog Oh, Ki-Duk Song, Suhkmann Kim, Byung-Wook Cho   +8 more
doaj   +1 more source

Flavin-containing monooxygenases: mutations, disease and drug response [PDF]

, 2008
NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Pharmacological Sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality ...
Phillips, IR, Shephard, EA
core   +1 more source

Transient trimethylaminuria related to menstruation

BMC Medical Genetics, 2007
Background Trimethylaminuria, or fish odor syndrome, includes a transient or mild malodor caused by an excessive amount of malodorous trimethylamine as a result of body secretions.
Yamazaki Hiroshi, Cashman John R, Shimizu Makiko   +2 more
doaj   +1 more source

Antibiotic-induced intestinal microbiota depletion can attenuate the acute kidney injury to chronic kidney disease transition via NADPH oxidase 2 and trimethylamine-N-oxide inhibition.

Kidney International
Intestinal microbiota and their metabolites affect systemic inflammation and kidney disease outcomes. Here, we investigated the key metabolites associated with the acute kidney injury (AKI)-to chronic kidney disease (CKD) transition and the effect of ...
Jeonghwan Lee, Jinhaeng Lee, Kyu-Hyeon Kim, Jiwon Lee, Youngae Jung, J. Hyeon, Areum Seo, Wencheng Jin, Boram Weon, Nayeon Shin, Sejoong Kim, Chun Soo Lim, Y. S. Kim, J. P. Lee, Geum-Sook Hwang, S. Yang   +15 more
semanticscholar   +1 more source

Gut Microbiota-Dependent Trimethylamine N-oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease

Circulation Research, 2014
Rationale: Trimethylamine-N-oxide (TMAO), a gut microbial-dependent metabolite of dietary choline, phosphatidylcholine (lecithin), and L-carnitine, is elevated in chronic kidney diseases (CKD) and associated with coronary artery disease pathogenesis ...
W. Tang, Zeneng Wang, David J. Kennedy, Yuping Wu, J. Buffa, Brendan Agatisa-Boyle, Xinmin S. Li, B. Levison, S. L. Hazen   +8 more
semanticscholar   +1 more source