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The biosynthesis of trimethylamine-N-oxide
Biochimica et Biophysica Acta, 1960 Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in
J, BAKER, S, CHAYKIN
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Iridium Corroles Exhibit Weak Near-Infrared Phosphorescence but Efficiently Sensitize Singlet Oxygen Formation. [PDF]
, 2020 Six-coordinate iridium(III) triarylcorrole derivatives, Ir[TpXPC)]L2, where TpXPC = tris(para-X-phenyl)corrole (X = CF3, H, Me, and OCH3) and L = pyridine (py), trimethylamine (tma), isoquinoline (isoq), 4-dimethylaminopyridine (dmap), and 4-picolinic ...
Borisov, Sergey M +3 more
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Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]
, 2019 The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V +3 more
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Trimethylamine-N-Oxide and Heart Failure
Journal of the American College of Cardiology, 2015 The new study by Tang et al. [(1)][1] demonstrating an inverse correlation of serum levels of trimethylamine- N -oxide (TMAO) with survival in patients with heart failure (HF) is intriguing and thought provoking. Similar findings have been published recently by Norwegian researchers.
McCarty, Mark F. +1 more
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Trimethylamine N-oxide and kidney diseases: what do we know?
Brazilian Journal of Nephrology, 2023 In the human gut, there is a metabolically active microbiome whose metabolic products reach various organs and are used in the physiological activities of the body.
Ozkan Gungor +2 more
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Multivariate statistical analysis for the identification of potential seafood spoilage indicators [PDF]
, 2017 Volatile organic compounds (VOCs) characterize the spoilage of seafood packaged under modified atmospheres (MAs) and could thus be used for quality monitoring.
Abatih, Emmanuel +6 more
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Trimethylamine N‐oxide: breathe new life [PDF]
British Journal of Pharmacology, 2017 Association between elevated levels of systemic trimethylamine N‐oxide (TMAO) and increased risk for adverse cardiovascular events have been proposed in recent years. Increasing experimental and clinical evidence in the last decade has implicated TMAO as an important contributor to the pathogenesis of cardiovascular diseases.
Saravanan Subramaniam, Craig Fletcher
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Molecules, 2020 A computational study of the structures and energetics of amine N-oxides, including pyridine N-oxides, trimethylamine N-oxide, bridgehead bicyclic amine N-oxides, and lactam N-oxides, allowed comparisons with published experimental data.
Arthur Greenberg +2 more
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Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N -oxide [PDF]
, 2017 Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocean and are important nitrogen source for bacteria. TMA monooxygenase (Tmm), a bacterial flavin-containing monooxygenase (FMO), is found widespread in marine bacteria and is ...
Chen, Xiu-Lan +16 more
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Microbiome, trimethylamine N-oxide, and cardiometabolic disease [PDF]
Translational Research, 2017 There is increasing appreciation that changes in microbiome composition and function can promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites that are biologically active, such as trimethylamine N-oxide (TMAO), are now recognized as contributors to atherogenesis.
W.H. Wilson Tang, Stanley L. Hazen
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