Results 21 to 30 of about 561,219 (291)

Trimethylamine N-Oxide (TMAO) and Trimethylamine (TMA) Determinations of Two Hadal Amphipods

Journal of Marine Science and Engineering, 2022
Hadal trenches are a unique habitat with high hydrostatic pressure, low temperature and scarce food supplies. Amphipods are the dominant scavenging metazoan species in this ecosystem.
Qi Liu, Shouwen Jiang, Wenhao Li, Binbin Pan, Qianghua Xu   +4 more
doaj   +1 more source

Gut microbiota-derived trimethylamine N-oxide contributes to abdominal aortic aneurysm through inflammatory and apoptotic mechanisms

Circulation, 2023
Background: Large-scale human and mechanistic mouse studies indicate a strong relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) and several cardiometabolic diseases.
Tyler W. Benson, K. Conrad, Xinmin S. Li, Zeneng Wang, Robert N. Helsley, R. Schugar, Taylor M. Coughlin, Caris A. Wadding-Lee, Salma Fleifil, Hannah M. Russell, Timothy Stone, M. Brooks, J. Buffa, K. Mani, M. Björck, A. Wanhainen, Naseer Sangwan, S. Biddinger, R. Bhandari, Akiirayi Ademoya, Crystal Pascual, W. Tang, M. Tranter, Scott J. Cameron, J. M. Brown, S. Hazen, A. P. Owens   +26 more
semanticscholar   +1 more source

Fecal Microbiome Composition Does Not Predict Diet‐Induced TMAO Production in Healthy Adults

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Trimethylamine‐N‐oxide (TMAO) is a small molecule derived from the metabolism of dietary nutrients by gut microbes and contributes to cardiovascular disease. Plasma TMAO increases following consumption of red meat.
Marc Ferrell, Peter Bazeley, Zeneng Wang, Bruce S. Levison, Xinmin S. Li, Xun Jia, Ronald M. Krauss, Rob Knight, Aldons J. Lusis, J. C. Garcia‐Garcia, Stanley L. Hazen, W. H. Wilson Tang   +11 more
doaj   +1 more source

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
core   +2 more sources

The N‐oxidation of trimethylamine in a Jordanian population. [PDF]

British Journal of Clinical Pharmacology, 1995
The ability to oxidise trimethylamine (TMA) to trimethylamine N‐oxide (TMAO) is distributed polymorphically within a British white population with the majority of individuals excreting greater than 90% of total urinary TMA as TMAO. The opposite extreme is characterised by a rare inborn error of TMA N‐oxidation known as the fish‐odour syndrome.
H F, Hadidi, S, Cholerton, S, Atkinson, Y M, Irshaid, N M, Rawashdeh, J R, Idle   +5 more
openaire   +2 more sources

Trimethylamine-N-oxide: a potential biomarker and therapeutic target in ischemic stroke

Frontiers in Neurology, 2023
Ischemic stroke is by far the most common cerebrovascular disease and a major burden to the global economy and public health. Trimethylamine-N-oxide (TMAO), a small molecule compound produced by the metabolism of intestinal microorganisms, is reportedly ...
Yuan Liu, Juan Qu, Junjie Xu, Aiming Gu, Dezhi Deng, Xiaodan Jia, Baoxiang Wang   +6 more
doaj   +1 more source

Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]

, 2013
Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A, Doyle, Jason, Fedorak, Richard N, Foshaug, Rae R, Slupsky, Carolyn M, Sydora, Beate C, Tso, Victor K   +6 more
core   +4 more sources

Gut Microbiota and Ischemic Stroke: The Role of Trimethylamine N-Oxide [PDF]

Journal of Stroke, 2019
Trimethylamine N-oxide (TMAO) is produced when trimethylamine, a waste product of gut microbes, is converted via hepatic flavin monooxygenases. As TMAO is a potential causative factor in various cardiovascular diseases (CVDs) considerable research ...
Hyo Suk Nam
doaj   +1 more source

Gut-Derived Metabolite, Trimethylamine-N-oxide (TMAO) in Cardio-Metabolic Diseases: Detection, Mechanism, and Potential Therapeutics

Pharmaceuticals, 2023
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely associated with diseases such as atherosclerosis and hypertension, and ...
Meyammai Shanmugham, S. Bellanger, C. H. Leo   +2 more
semanticscholar   +1 more source

Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease [PDF]

, 2016
Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in the metabolism of therapeutic drugs. However, on a daily basis we are exposed to one of the most abundant substrates of the enzyme, trimethylamine, which is released ...
Fennema, D, Phillips, IR, Shephard, EA
core   +1 more source