Results 21 to 30 of about 17,902 (223)

The biosynthesis of trimethylamine-N-oxide

Biochimica et Biophysica Acta, 1960
Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in
J, BAKER, S, CHAYKIN
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Trimethylamine N-oxide and kidney diseases: what do we know?

Brazilian Journal of Nephrology, 2023
In the human gut, there is a metabolically active microbiome whose metabolic products reach various organs and are used in the physiological activities of the body.
Ozkan Gungor, Nuri Baris Hasbal, Demet Alaygut   +2 more
doaj   +2 more sources

Trimethylamine-N-Oxide and Heart Failure

Journal of the American College of Cardiology, 2015
The new study by Tang et al. [(1)][1] demonstrating an inverse correlation of serum levels of trimethylamine- N -oxide (TMAO) with survival in patients with heart failure (HF) is intriguing and thought provoking. Similar findings have been published recently by Norwegian researchers.
McCarty, Mark F., DiNicolantonio, James J.   +1 more
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Trimethylamine N-oxide (TMAO) in human health

EXCLI journal, 2021
Due to numerous links between trimethylamine-N-oxide (TMAO) and various disorders and diseases, this topic is very popular and is often taken up by researchers. TMAO is a low molecular weight compound that belongs to the class of amine oxides. It is formed by the process of oxidation of trimethylamine (TMA) by the hepatic flavin monooxygenases (FMO1 ...
Gatarek, Paulina, Kaluzna-Czaplinska, Joanna   +1 more
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Computational Study of Selected Amine and Lactam N-Oxides Including Comparisons of N-O Bond Dissociation Enthalpies with Those of Pyridine N-Oxides

Molecules, 2020
A computational study of the structures and energetics of amine N-oxides, including pyridine N-oxides, trimethylamine N-oxide, bridgehead bicyclic amine N-oxides, and lactam N-oxides, allowed comparisons with published experimental data.
Arthur Greenberg, Alexa R. Green, Joel F. Liebman   +2 more
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Trimethylamine N‐oxide: breathe new life [PDF]

British Journal of Pharmacology, 2017
Association between elevated levels of systemic trimethylamine N‐oxide (TMAO) and increased risk for adverse cardiovascular events have been proposed in recent years. Increasing experimental and clinical evidence in the last decade has implicated TMAO as an important contributor to the pathogenesis of cardiovascular diseases.
Saravanan Subramaniam, Craig Fletcher
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Microbiome, trimethylamine N-oxide, and cardiometabolic disease [PDF]

Translational Research, 2017
There is increasing appreciation that changes in microbiome composition and function can promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites that are biologically active, such as trimethylamine N-oxide (TMAO), are now recognized as contributors to atherogenesis.
W.H. Wilson Tang, Stanley L. Hazen
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Influence of Trimethylamine N-Oxide on Platelet Activation

Nutrients, 2022
Microbiome-derived trimethylamine N-oxide (TMAO) has been associated with platelet hyperreactivity and subsequent atherogenesis. Whether physiological TMAO-levels influence platelet-derived lipid mediators remains unknown. Little is known about pre-analytic factors potentially influencing TMAO concentrations. We aimed at developing a quantitative LC-MS/
Emonds, Julian Josef, Ringel, Clemens, Reinicke, Madlen, Müller, Daniel, Von Eckardstein, Arnold, Meixensberger, Jürgen, Ceglarek, Uta, Gaudl, Alexander   +7 more
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The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

Frontiers in Endocrinology, 2023
Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide. Researchers have found that the occurrence and development of CVDs are closely related to intestinal microecology.
Jing Zhen, Jing Zhen, Zhou Zhou, Meng He, Hai-Xiang Han, En-Hui Lv, Peng-Bo Wen, Xin Liu, Yan-Ting Wang, Xun-Chao Cai, Jia-Qi Tian, Meng-Ying Zhang, Lei Xiao, Xing-Xing Kang   +13 more
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Quantification of Trimethylamine-N-Oxide and Trimethylamine in Fish Oils for Human Consumption

Molecules
Supplementing fish oil is one of the strategies to reduce the risk of cardiovascular disease, the leading cause of death around the world. Contradictorily, fish oil may also contain trimethylamine-N-oxide, a recently emerged risk factor for ...
Dominik Dörfel, Sascha Rohn, Eckard Jantzen   +2 more
doaj   +1 more source