Results 101 to 110 of about 561,219 (291)

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

HYPERTENSION, 2020
Supplemental Digital Content is available in the text. Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases.
Vienna E. Brunt, R. Gioscia-Ryan, Abigail G. Casso, Nicholas S. VanDongen, B. Ziemba, Zachary J. Sapinsley, James J. Richey, Melanie C. Zigler, A. Neilson, K. Davy, D. Seals   +10 more
semanticscholar   +1 more source

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

Nature Communications, 2023
The host-microbiota co-metabolite trimethylamine N-oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are regulated remains unclear.
P. Andrikopoulos, J. Aron‐Wisnewsky, R. Chakaroun, A. Myridakis, S. Forslund, T. Nielsen, S. Adriouch, Bridget Holmes, J. Chilloux, S. Vieira-Silva, G. Falony, J. Salem, Fabrizio Andreelli, Eugeni Belda, J. Kieswich, K. Chechi, F. Puig-Castellví, Mickaël Chevalier, E. Le Chatelier, M. Olanipekun, Lesley Hoyles, Renato J Alves, Gérard Helft, R. Isnard, L. Køber, Luis Pedro Coelho, C. Rouault, Dominique Gauguier, J. Gøtze, Edi Prifti, P. Froguel, Jean-Daniel Zucker, F. Bäckhed, H. Vestergaard, T. Hansen, J. Oppert, M. Blüher, Jens Nielsen, J. Raes, P. Bork, Muhammad M Yaqoob, M. Stumvoll, Oluf Pedersen, S. Ehrlich, Karine Clément, M. Dumas   +45 more
semanticscholar   +1 more source

Recent Advance for PVDF Based Flexible Piezoelectric Sensors

EcoEnergy, EarlyView.
This review focus on the structural regulation of PVDF via boundary confinement, blending regulation, electric‐field‐assisted orientation, and chemical modification for flexible piezoelectric sensors. ABSTRACT The rapid advancement of flexible electronics, wearable devices, and biomedical engineering has spurred increasing demand for sensor materials ...
Chaoran Tan, Aokai Yang, Yuyang Ling, Meilin Liu, Liang Huang   +4 more
wiley   +1 more source

Reduction of trimethylamine N-oxide to trimethylamine by the human gut microbiota: supporting evidence for ‘metabolic retroversion’ [PDF]

, 2015
Dietary sources of methylamines such as choline, trimethylamine (TMA), trimethylamine N-oxide (TMAO), phosphatidylcholine (PC) and carnitine are present in a number of foodstuffs, including meat, fish, nuts and eggs.
Chilloux, J, Dumas, ME, Hoyles, L, Jiménez-Pranteda, ML, McCartney, AL   +4 more
core   +3 more sources

Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota

Microbiome, 2018
Background The dietary methylamines choline, carnitine, and phosphatidylcholine are used by the gut microbiota to produce a range of metabolites, including trimethylamine (TMA).
Lesley Hoyles, Maria L. Jiménez-Pranteda, Julien Chilloux, Francois Brial, Antonis Myridakis, Thomas Aranias, Christophe Magnan, Glenn R. Gibson, Jeremy D. Sanderson, Jeremy K. Nicholson, Dominique Gauguier, Anne L. McCartney, Marc-Emmanuel Dumas   +12 more
doaj   +1 more source

Trimethylamine N-Oxide Promotes Cell Proliferation and Angiogenesis in Colorectal Cancer

Journal of Immunology Research, 2022
Background. Of all intestinal microbiome-derived metabolites, trimethylamine N-oxide (TMAO) has received increasing attention because of its potent role in colorectal cancer development.
Shuyan Yang, Hui Dai, Yimei Lu, Rui Li, Chengjin Gao, Shuming Pan   +5 more
doaj   +1 more source

Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy

Frontiers in Cardiovascular Medicine, 2021
Atherosclerosis is associated with various pathological manifestations, such as ischemic heart disease, ischemic stroke, and peripheral arterial disease, and remains a leading cause of public health concern.
BingYu Wang, Jun Qiu, JiangFang Lian, JiangFang Lian, Xi Yang, JianQing Zhou, JianQing Zhou   +6 more
doaj   +1 more source

Synthesis and alkyne-coupling chemistry of cyclomanganated 1- and 3-acetylindoles, 3-formylindole and analogues [PDF]

, 2006
The syntheses are reported of new cyclomanganated indole derivatives (1-acetyl-κO-indolyl-κC2)dicarbonylbis(trimethylphosphite)manganese (2), (1-methyl-3-acetyl-κO-indolyl-κC2)tetracarbonylmanganese (4), (3-formyl-κO-indolyl-κC2)tetracarbonylmanganese ...
Depree, Gary J., Jameson, Geoffrey B., Main, Lyndsay, Nicholson, Brian K., Robinson, Nicholas P.   +4 more
core   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

A New Light on Vitamin D in Obesity: A Novel Association with Trimethylamine-N-Oxide (TMAO) [PDF]

, 2019
: Vitamin D deficiency and obesity are two public health problems extensively exacerbated over the last years. Among the several mechanisms proposed to account for the complex interplay between vitamin D and obesity, one that has gained particular ...
Annunziata, G., Barrea, L., Colao, A., de Alteriis, G., Laudisio, D., Muscogiuri, G., Savastano, S., Tenore, G. C.   +7 more
core   +1 more source