Results 111 to 120 of about 14,468,554 (196)

The microbial metabolite trimethylamine N-oxide and the kidney diseases

Frontiers in Cellular and Infection Microbiology
Trimethylamine N-oxide (TMAO), a metabolite, is a co-metabolite produced by both gut microbiota and livers, originating from foods rich in choline or carnitine.
Jin-Qi Su, Jin-Qi Su, Xiang-Qi Wu, Xiang-Qi Wu, Qi Wang, Qi Wang, Bo-Yang Xie, Bo-Yang Xie, Cui-Yan Xiao, Cui-Yan Xiao, Hong-Yong Su, Hong-Yong Su, Ji-Xin Tang, Ji-Xin Tang, Cui-Wei Yao, Cui-Wei Yao   +15 more
doaj   +1 more source

Effect of egg ingestion on trimethylamine-N-oxide production in humans: a randomized, controlled, dose-response study [PDF]

, 2014
Background: It is important to understand whether eating eggs, which are a major source of dietary choline, results in increased exposure to trimethylamine-N-oxide (TMAO), which is purported to be a risk factor for developing heart ...
Corbin, Karen D., Bennett, Brian J., Miller, Carolyn A., Zhang, Shucha, Blevins, Tondra, Da Costa, Kerry Ann, O'Connor, Annalouise, Galanko, Joseph A., Zhao, Xueqing, Zeisel, Steven H.   +9 more
core   +1 more source

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

The FEBS Journal, EarlyView.
C‐type lectins (CTLs) are involved in the detection of viral/microbial carbohydrates. We studied a family of soluble CTLs in the mosquito Aedes aegypti, which acts as a vector for viruses like dengue and Zika. Using crystallography, biophysics, and structure prediction approaches, we found that these proteins consistently pair together in the same ...
Mattia Bertinelli, Rupesh Balaji Jayachandran, Jack Whitehead, Cédric Leyrat, Annabel v. Clanner, Guido C Paesen, Max Renner   +6 more
wiley   +1 more source

Trimethylamine N-oxide impairs β-cell function and glucose tolerance

Nature Communications
β-Cell dysfunction and β-cell loss are hallmarks of type 2 diabetes (T2D). Here, we found that trimethylamine N-oxide (TMAO) at a similar concentration to that found in diabetes could directly decrease glucose-stimulated insulin secretion (GSIS) in MIN6 ...
Lijuan Kong, Qijin Zhao, Xiaojing Jiang, Jinping Hu, Qian Jiang, Li Sheng, Xiaohong Peng, Shusen Wang, Yibing Chen, Yanjun Wan, Shaocong Hou, Xingfeng Liu, Chunxiao Ma, Yan Li, Li Quan, Liangyi Chen, Bing Cui, Pingping Li   +17 more
doaj   +1 more source

Adaptation to extreme environments: A review of Antarctic fish physiology

Journal of Fish Biology, EarlyView.
Abstract Having evolved in the chronically cold and thermally stable waters of the Southern Ocean (SO) for millions of years, Antarctic fish possess a suite of physiological specializations that enable them to survive at temperatures near the freezing point of seawater. Adaptations include the evolution of antifreeze proteins, modifications of membrane
Seungyeon Lee, Sachithra Amarin Hettiarachchi, Il‐Chan Kim, Jae‐Seong Lee, Thomas Desvignes, Julia M. York, Laura Ghigliotti, Jilda Alicia Caccavo, Jin‐Hyoung Kim   +8 more
wiley   +1 more source

Porphyromonas gingivalis drives trimethylamine-N-oxide accumulation via modulation of gut microbial trimethylamine lyase in mice

Frontiers in Microbiology
IntroductionTrimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, is linked to cardiovascular, neurodegenerative, and metabolic diseases. Emerging evidence indicates a bidirectional interaction between the periodontal pathogen Porphyromonas
Weige Xie, Dong Han, Jinlu Tan, Dan Zhao, Jingwen Dong, Juan Wu, Xuebin Yang, Sijing Xie   +7 more
doaj   +1 more source

Trimethylamine N -Oxide

Recent evidence, including massive gene-expression analysis and a wide-variety of other multi-omics approaches, demonstrates an interplay between gut microbiota and the regulation of plasma lipids. Gut microbial metabolism of choline and -carnitine results in the formation of trimethylamine (TMA) and concomitant conversion into trimethylamine- N -oxide
Canyelles, Marina||, Tondo Colomer, Mireia||, Cedó, Lídia||, Farràs Mañé, Marta||, Escolà-Gil, Joan Carles||, Blanco Vaca, Francisco||   +5 more
openaire   +1 more source

Four Haylages, One Metabonome: Defining Diet Driven Metabolic Shifts in Ponies

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT Haylage is widely fed to all categories of stabled horses across Europe and New Zealand. Haylage can vary from high energy nutrient dense forage to low energy highly fibrous fodder, yet little is known about the impact different haylages have on metabolism in horses.
Meriel Moore‐Colyer, Pat Harris, Simon Daniels   +2 more
wiley   +1 more source

Divergence between circulating trimethylamine and trimethylamine-N-oxide associated with common flavin-containing monooxygenase 3 variation

iScience
Summary: Flavin-containing monooxygenase 3 (FMO3) oxidizes trimethylamine (TMA), a gut-derived metabolite of dietary substrates such as choline and betaine, into trimethylamine-N-oxide (TMAO), which has been linked to cardiometabolic and renal diseases ...
Justin Tang, Joshua A. Zaretsky, Jaden D. Labajo, Abir Shaqo, Hamza Dakroub, Gia V. Shelp, Elizabeth M. Poole, Sarah E. Burns, Clara E. Cho   +8 more
doaj   +1 more source

Correction to “Mutual Exclusion of Urea and Trimethylamine N‑Oxide from Amino Acids in Mixed Solvent Environment”

, 2015
Correction to “Mutual Exclusion of Urea and Trimethylamine N‑Oxide from Amino Acids in Mixed Solvent ...
Nico F. A. van der Vegt (1352664), Pritam Ganguly (1235004), Timir Hajari (1235010), Joan-Emma Shea (1235013)   +3 more
core   +1 more source