Results 111 to 120 of about 561,219 (291)

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Trimethylamine-N-oxide is an independent risk factor for hospitalization events in patients receiving maintenance hemodialysis

Renal Failure, 2020
Background Hospitalization is a significant outcome measurement for maintenance hemodialysis pantients. Trimethylamine-N-oxide (TMAO), created by gut microflora from dietary l-carnitine and choline, cleared by the kidney, has been implicated in the ...
Yin Zheng, Zihui Tang, Li You, Yuanhao Wu, Junfeng Liu, Jun Xue   +5 more
doaj   +1 more source

From Phosphinimines to Four‐Membered SiCPN Cations: Insights Into N–Si Bonding and Ring Strain

European Journal of Inorganic Chemistry, EarlyView.
Sterically tuned N‐silyl phosphinimines enable four‐membered SiCPN cations. Hydride abstraction yields cyclic cations for Me and iPr substituents at silicon, while tBu gives a protonated intermediate. Multinuclear NMR spectroscopy, X‐ray crystallography, thermochemical density functional theory investigations, and natural bond orbital analyses reveal ...
Alexander Falk, Jonathan O. Bauer
wiley   +1 more source

Restored mutant receptor:Corticoid binding in chaperone complexes by trimethylamine N-oxide. [PDF]

PLoS ONE, 2017
Without a glucocorticoid (GC) ligand, the transcription factor glucocorticoid receptor (GR) is largely cytoplasmic, with its GC-binding domain held in high affinity conformation by a cluster of chaperones.
Aaron L Miller, W Austin Elam, Betty H Johnson, Shagufta H Khan, Raj Kumar, E Brad Thompson   +5 more
doaj   +1 more source

Microbial trimethylamine metabolism in marine environments [PDF]

, 2019
Trimethylamine (TMA) is common in marine environments. Although the presence of this compound in the oceans has been known for a long time, unlike the mammalian gastrointestinal tract, where TMA metabolism by microorganisms has been studied intensely ...
Chen, Yin, Giovannoni, Stephen J., Mausz, Michaela A., Sun, Jing   +3 more
core   +1 more source

Tracking the Reaction of Organoazides with Linear Chromium Silylamides

European Journal of Inorganic Chemistry, EarlyView.
The multifaceted outcome of the interaction of linear chromium silylamides with organoazides is presented. It leads to terminal and bridging imido complexes, as well as azide adducts. With acylazide, a terminal chromium oxide is obtained. The reaction of organoazides with a linear chromium(I) silylamide leads to the observation of rare monomeric and ...
Andres Gonzalez, Sophie Schäfer, Ting‐Yi Chen, Serhiy Demeshko, Franc Meyer, C. Gunnar Werncke   +5 more
wiley   +1 more source

Metagenomic data-mining reveals contrasting microbial populations responsible for trimethylamine formation in human gut and marine ecosystems [PDF]

, 2016
Existing metagenome datasets from many different environments contain untapped potential for understanding metabolic pathways and their biological impact.
Airs, Ruth, Chen, Yin, Doxey, Andrew C., Jameson, Eleanor, Murrell, J. C. (J. Colin), Purdy, Kevin J.   +5 more
core   +1 more source

Novel ionization reagent for the measurement of gas-phase ammonia and amines using a stand-alone atmospheric pressure gas chromatography (APGC) source. [PDF]

, 2020
RationaleContaminants present in ambient air or in sampling lines can interfere with the target analysis through overlapping peaks or causing a high background. This study presents a positive outcome from the unexpected presence of N-methyl-2-pyrrolidone,
Finlayson-Pitts, Barbara J, Li, Xiaoxiao, Perraud, Véronique, Smith, James N   +3 more
core   +1 more source

Pressing the trimethylamine N-oxide narrative

AME Medical Journal, 2017
We read with interest the correspondence titled “Gut Microbe-Generated Trimethylamine N-Oxide from Dietary Choline is Prothrombotic in Subjects”, published by Zhu et al . in the journal Circulation (1). This work builds on an emerging body of evidence which has suggested a role for the gut-derived metabolite, trimethylamine N -oxide (TMAO), in the ...
Kevin C. Klatt, Marie A. Caudill
openaire   +1 more source

Body‐integrated photonic biosensors: Illuminating the path to active healthcare

FlexMat, EarlyView.
Body‐integrated photonic biosensors are promising tools for active healthcare. These optical devices can be worn, implanted, or swallowed to monitor health signals continuously. This review introduces key sensing modalities, including fluorescence, colorimetry, SPR, LSPR, SERS, and light‐modulating materials.
Jiayue Gu, Xingming Wen, Qihang Yan, Yining Zhao, Linghao Yuan, Siyuan Chen, Yue Ma, Zhengyue Fang, Dong Lei, Yuxin Liu, Ze Xiong   +10 more
wiley   +1 more source