Trimethylamine-N-oxide damages astrocytes and lymphatic endothelial cells in the cerebral lymphatic system. [PDF]
IBRO Neurosci RepSu ML +8 more
europepmc +3 more sources
Trimethylamine N‐oxide: breathe new life [PDF]
British Journal of Pharmacology, 2017 Association between elevated levels of systemic trimethylamine N‐oxide (TMAO) and increased risk for adverse cardiovascular events have been proposed in recent years. Increasing experimental and clinical evidence in the last decade has implicated TMAO as an important contributor to the pathogenesis of cardiovascular diseases.
Saravanan Subramaniam, Craig Fletcher
openaire +2 more sources
High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide
Science, 2021 Gut bugs and systemic disease risk What people eat has an immediate selective effect on the microbial populations resident in the gut. A high-fat diet is associated with the occurrence of microbes that catabolize choline and the accumulation of ...
Woongjae Yoo +18 more
semanticscholar +1 more source
Trimethylamine and trimethylamine N-oxide, a flavin-containing monooxygenase 3 (FMO3)-mediated host-microbiome metabolic axis implicated in health and disease [PDF]
, 2016 Flavin-containing monooxygenase 3 (FMO3) is known primarily as an enzyme involved in the metabolism of therapeutic drugs. However, on a daily basis we are exposed to one of the most abundant substrates of the enzyme, trimethylamine, which is released ...
Fennema, D, Phillips, IR, Shephard, EA
core +1 more source
Iridium Corroles Exhibit Weak Near-Infrared Phosphorescence but Efficiently Sensitize Singlet Oxygen Formation. [PDF]
, 2020 Six-coordinate iridium(III) triarylcorrole derivatives, Ir[TpXPC)]L2, where TpXPC = tris(para-X-phenyl)corrole (X = CF3, H, Me, and OCH3) and L = pyridine (py), trimethylamine (tma), isoquinoline (isoq), 4-dimethylaminopyridine (dmap), and 4-picolinic ...
Borisov, Sergey M +3 more
core +2 more sources
Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]
, 2013 Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A +6 more
core +2 more sources
Multivariate statistical analysis for the identification of potential seafood spoilage indicators [PDF]
, 2017 Volatile organic compounds (VOCs) characterize the spoilage of seafood packaged under modified atmospheres (MAs) and could thus be used for quality monitoring.
Abatih, Emmanuel +6 more
core +2 more sources
The biosynthesis of trimethylamine-N-oxide
Biochimica et Biophysica Acta, 1960 Norris and Benoit (1) provided ‘good evidence that injected trimethylamine is converted in the rat to its N-oxide and excreted in the urine. Other mammals have been shown to have the ability to effect the same reaction (2, 3). In a preliminary communication (4), we have reported that hog liver microsomes will catalyze the oxidation of trimethylamine in
J, BAKER, S, CHAYKIN
openaire +3 more sources
Seasonal changes in microbial dissolved organic sulfur transformations in coastal waters [PDF]
, 2020 The marine trace gas dimethylsulfide (DMS) is the single most important biogenic source of atmospheric sulfur, accounting for up to 80% of global biogenic sulfur emissions.
Dixon, Joanna L. +3 more
core +1 more source
Molecules, 2020 A computational study of the structures and energetics of amine N-oxides, including pyridine N-oxides, trimethylamine N-oxide, bridgehead bicyclic amine N-oxides, and lactam N-oxides, allowed comparisons with published experimental data.
Arthur Greenberg +2 more
doaj +1 more source