Results 31 to 40 of about 453,912 (274)

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]

, 2019
The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V, Sharpton, Suzanne R, Terrault, Norah A, Yong, Germaine JM   +3 more
core   +1 more source

Microbiome, trimethylamine N-oxide, and cardiometabolic disease [PDF]

Translational Research, 2017
There is increasing appreciation that changes in microbiome composition and function can promote long-term susceptibility for cardiometabolic risk. Gut microbe-derived metabolites that are biologically active, such as trimethylamine N-oxide (TMAO), are now recognized as contributors to atherogenesis.
W.H. Wilson Tang, Stanley L. Hazen
openaire   +2 more sources

Trimethylamine N-oxide and kidney diseases: what do we know?

Brazilian Journal of Nephrology, 2023
In the human gut, there is a metabolically active microbiome whose metabolic products reach various organs and are used in the physiological activities of the body.
Ozkan Gungor, Nuri Baris Hasbal, Demet Alaygut   +2 more
doaj   +2 more sources

Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome

npj Biofilms and Microbiomes, 2021
Trimethylamine- N -oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis.
Xingxing Li, Chunyan Su, Zhibo Jiang, Yuxin Yang, Yue Zhang, Mengxia Yang, Xiumin Zhang, Yu Du, Jin Zhang, Li Wang, Jiandong Jiang, B. Hong   +11 more
semanticscholar   +1 more source

Gut-Derived Serum Lipopolysaccharide is Associated With Enhanced Risk of Major Adverse Cardiovascular Events in Atrial Fibrillation: Effect of Adherence to Mediterranean Diet [PDF]

, 2017
Gut microbiota is emerging as a novel risk factor for atherothrombosis, but the predictive role of gut-derived lipopolysaccharide (LPS) is unknown. We analyzed (1) the association between LPS and major adverse cardiovascular events (MACE) in atrial ...
Cammisotto, Vittoria, Carnevale, Roberto, Menichelli, Danilo, Nocella, Cristina, Novo, Marta, Pastori, Daniele, Pignatelli, Pasquale, Santulli, Maria, Violi, Francesco   +8 more
core   +1 more source

Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota

mBio, 2016
The gut microbiota is found to be strongly associated with atherosclerosis (AS). Resveratrol (RSV) is a natural phytoalexin with anti-AS effects; however, its mechanisms of action remain unclear.
Ming‐liang Chen, Long Yi, Yong Zhang, Xi Zhou, Li Ran, Jining Yang, Jun‐dong Zhu, Qian‐yong Zhang, M. Mi   +8 more
semanticscholar   +1 more source

Gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice.

Blood, 2020
The diversity of human microbiome heralds the difference of impact that gut microbial metabolites exert on allogenic graft-versus-host disease (GVHD), even though short-chain fatty acids and indole were demonstrated to reduce its severity. In this study,
Kunpeng Wu, Yan Yuan, Huihui Yu, Xin Dai, Shu Wang, Zhengxu Sun, Fen Wang, He Fei, Qiwang Lin, Hua Jiang, Tong Chen   +10 more
semanticscholar   +1 more source

Influence of Trimethylamine N-Oxide on Platelet Activation

Nutrients, 2022
Microbiome-derived trimethylamine N-oxide (TMAO) has been associated with platelet hyperreactivity and subsequent atherogenesis. Whether physiological TMAO-levels influence platelet-derived lipid mediators remains unknown. Little is known about pre-analytic factors potentially influencing TMAO concentrations. We aimed at developing a quantitative LC-MS/
Emonds, Julian Josef, Ringel, Clemens, Reinicke, Madlen, Müller, Daniel, Von Eckardstein, Arnold, Meixensberger, Jürgen, Ceglarek, Uta, Gaudl, Alexander   +7 more
openaire   +3 more sources

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis. [PDF]

, 2020
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects synovial joints, leading to inflammation, joint destruction, loss of function, and disability.
Coras, Roxana, Guma, Monica, Murillo-Saich, Jessica D   +2 more
core   +2 more sources

Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans

HYPERTENSION, 2020
Supplemental Digital Content is available in the text. Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases.
Vienna E. Brunt, R. Gioscia-Ryan, Abigail G. Casso, Nicholas S. VanDongen, B. Ziemba, Zachary J. Sapinsley, James J. Richey, Melanie C. Zigler, A. Neilson, K. Davy, D. Seals   +10 more
semanticscholar   +1 more source