Results 41 to 50 of about 453,912 (274)

Untargeted lipidomic features associated with colorectal cancer in a prospective cohort. [PDF]

, 2018
BackgroundEpidemiologists are beginning to employ metabolomics and lipidomics with archived blood from incident cases and controls to discover causes of cancer.
Cai, Xiaoming, Dudoit, Sandrine, Edmands, William MB, Grigoryan, Hasmik, Gunter, Marc J, Naccarati, Alessio, Perttula, Kelsi, Petrick, Lauren, Polidoro, Silvia, Rappaport, Stephen M, Schiffman, Courtney, Vineis, Paolo   +11 more
core   +3 more sources

TMAO metaorganismal pathway and chronic inflammatory diseases [PDF]

Exploration of Medicine
Nutrients containing a trimethylamine (TMA) moiety in their structure can be metabolized by the gut microbiota through enzymatic cleavage of the C-N bond, producing TMA.
Zeneng Wang, Shumei Man, Robert Koeth
doaj   +1 more source

Gut-Derived Metabolite, Trimethylamine-N-oxide (TMAO) in Cardio-Metabolic Diseases: Detection, Mechanism, and Potential Therapeutics

Pharmaceuticals, 2023
Trimethylamine N-oxide (TMAO) is a biologically active gut microbiome-derived dietary metabolite. Recent studies have shown that high circulating plasma TMAO levels are closely associated with diseases such as atherosclerosis and hypertension, and ...
Meyammai Shanmugham, S. Bellanger, Chen Huei Leo   +2 more
semanticscholar   +1 more source

Trimethylamine N‐Oxide Promotes Vascular Inflammation Through Signaling of Mitogen‐Activated Protein Kinase and Nuclear Factor‐κB

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
The choline‐derived metabolite trimethylamine N‐oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk.
M. Seldin, Yonghong Meng, Hongxiu Qi, Weifei Zhu, Zeneng Wang, S. Hazen, A. Lusis, D. Shih   +7 more
semanticscholar   +1 more source

Trimethylamine-N-Oxide and Heart Failure

Journal of the American College of Cardiology, 2015
The new study by Tang et al. [(1)][1] demonstrating an inverse correlation of serum levels of trimethylamine- N -oxide (TMAO) with survival in patients with heart failure (HF) is intriguing and thought provoking. Similar findings have been published recently by Norwegian researchers.
McCarty, Mark F., DiNicolantonio, James J.   +1 more
openaire   +2 more sources

Trace metal requirements for microbial enzymes involved in the production and consumption of methane and nitrous oxide [PDF]

, 2012
Fluxes of greenhouse gases to the atmosphere are heavily influenced by microbiological activity. Microbial enzymes involved in the production and consumption of greenhouse gases often contain metal cofactors.
Glass, Jennifer B., Orphan, Victoria J.
core   +3 more sources

Intestinal Microbiota Metabolism and Atherosclerosis

Chinese Medical Journal, 2015
Objective: This review aimed to summarize the relationship between intestinal microbiota metabolism and cardiovascular disease (CVD) and to propose a novel CVD therapeutic target.
Tian-Xing Liu, Hai-Tao Niu, Shu-Yang Zhang   +2 more
doaj   +1 more source

Higher Trimethylamine-N-Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria

mSystems, 2021
The gut microbiota-dependent metabolite trimethylamine-N-oxide (TMAO) is linked to an increased risk for cardiovascular diseases. Trimethylamine (TMA), which is subsequently oxidized to TMAO in the liver, is formed by intestinal bacteria via distinct ...
Silke Rath, Katharina Rox, Sven Kleine Bardenhorst, Ulf Schminke, Marcus Dörr, Julia Mayerle, Fabian Frost, Markus M. Lerch, André Karch, Mark Brönstrup, Dietmar H. Pieper, Marius Vital   +11 more
doaj   +1 more source

Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target

Nutrients, 2018
Trimethylamine N-oxide (TMAO) is a molecule generated from choline, betaine, and carnitine via gut microbial metabolism. The plasma level of TMAO is determined by several factors including diet, gut microbial flora, drug administration and liver flavin ...
M. H. Janeiro, M. Ramírez, F. Milagro, J. Martínez, M. Solas   +4 more
semanticscholar   +1 more source

Evidence of a causal and modifiable relationship between kidney function and circulating trimethylamine N-oxide

Nature Communications, 2023
The host-microbiota co-metabolite trimethylamine N-oxide (TMAO) is linked to increased cardiovascular risk but how its circulating levels are regulated remains unclear.
P. Andrikopoulos, J. Aron‐Wisnewsky, R. Chakaroun, Antonis Myridakis, S. Forslund, T. Nielsen, S. Adriouch, Bridget Holmes, J. Chilloux, S. Vieira-Silva, G. Falony, Joe-Elie Salem, Fabrizio Andreelli, Eugeni Belda, J. Kieswich, K. Chechi, F. Puig-Castellví, Mickael Chevalier, E. Le Chatelier, Michael T Olanipekun, Lesley Hoyles, Renato J Alves, Gérard Helft, R. Isnard, L. Køber, Luis Pedro Coelho, C. Rouault, Dominique Gauguier, J. Gøtze, Edi Prifti, P. Froguel, Jean-Daniel Zucker, F. Bäckhed, H. Vestergaard, T. Hansen, J. Oppert, Matthias Blüher, Jens Nielsen, J. Raes, P. Bork, Muhammad M. Yaqoob, M. Stumvoll, Oluf Pedersen, S. Ehrlich, Karine Clément, M. Dumas   +45 more
semanticscholar   +1 more source