Results 71 to 80 of about 453,912 (274)

Association between plasma trimethylamine N-oxide level and atrial fibrillation [PDF]

Jichu yixue yu linchuang
Objective To explore the relationship between plasma trimethylamine N-oxide(TMAO) level and atrial fibrillation(AF) by a clinical trial. Methods Totally 257 patients with AF were enrolled including 114 patients with paroxysmal AF and 143 with ...
YANG Wentao, ZHAO Qing, LI Xiangdong, WANG Yutang, LIU Wei
doaj   +1 more source

Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II–induced hypertension

Redox Biology, 2021
Gut microbiota produce Trimethylamine N-oxide (TMAO) by metabolizing dietary phosphatidylcholine, choline, l-carnitine and betaine. TMAO is implicated in the pathogenesis of chronic kidney disease (CKD), diabetes, obesity and atherosclerosis.
Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng   +19 more
doaj   +1 more source

Escherichia coli TatA and TatB Proteins Have N-out, C-in Topology in Intact Cells [PDF]

, 2012
The twin arginine protein transport (Tat) system translocates folded proteins across the cytoplasmic membrane of prokaryotes and the thylakoid membrane of chloroplasts.
Alami, Bartolomé, Bauer, Berks, Bernhardt, Berthelmann, Bogsch, Bolhuis, Bryson, Buchanan, Casadaban, Chan, Cline, Cline, Dabney-Smith, Dabney-Smith, de Leeuw, De Leeuw, Gohlke, Gouffi, Greene, Hashimoto-Gotoh, Heijne, Hu, Ize, Jack, Jack, Laemmli, Leake, Lee, Leive, Lu, Maegawa, Maldonado, Mori, Mori, Palmer, Palmer, Porcelli, Punginelli, Richter, Sambrook, Sargent, Sargent, Sargent, Sauvé, Silvestro, Simons, Stanley, Stevenson, Tarry, Tarry, Towbin, Walther, Wang, Weiner, Wessel, Wexler, Yen   +58 more
core   +3 more sources

Targeting Trimethylamine N-Oxide: A New Therapeutic Strategy for Alleviating Atherosclerosis

Frontiers in Cardiovascular Medicine, 2022
Atherosclerosis (AS) is one of the most common cardiovascular diseases (CVDs), and there is currently no effective drug to reverse its pathogenesis. Trimethylamine N-oxide (TMAO) is a metabolite of the gut flora with the potential to act as a new risk ...
Lele Jing, Honghong Zhang, Qiannan Xiang, Liang Shen, Xiaoxia Guo, Changlin Zhai, Huilin Hu   +6 more
doaj   +1 more source

Research advances of trimethylamine N-oxide and chronic kidney diseases

Linchuang shenzangbing zazhi, 2021
Trimethylamine N-oxide（TMAO）is an important gut microbiota-dependent metabolite.Currently many clinical studies have confirmed the correlation between TMAO and the prognosis of chronic kidney disease（CKD）patients.This review summarized the latest ...
Liu Mei-jun, Zhou Wen-hua, Zhao Jing, Cui Wen-Peng   +3 more
doaj  

Trimethylamine N-Oxide Promotes Cell Proliferation and Angiogenesis in Colorectal Cancer

Journal of Immunology Research, 2022
Background. Of all intestinal microbiome-derived metabolites, trimethylamine N-oxide (TMAO) has received increasing attention because of its potent role in colorectal cancer development.
Shuyan Yang, Hui Dai, Yimei Lu, Rui Li, Chengjin Gao, Shuming Pan   +5 more
doaj   +1 more source

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease

Alzheimer's Research & Therapy, 2018
Trimethylamine N-oxide (TMAO), a small molecule produced by the metaorganismal metabolism of dietary choline, has been implicated in human disease pathogenesis, including known risk factors for Alzheimer’s disease (AD), such as metabolic, cardiovascular,
Nicholas M. Vogt, Kymberleigh A. Romano, B. Darst, C. Engelman, Sterling C. Johnson, C. Carlsson, S. Asthana, K. Blennow, H. Zetterberg, B. Bendlin, F. Rey   +10 more
semanticscholar   +1 more source

Pressing the trimethylamine N-oxide narrative

AME Medical Journal, 2017
We read with interest the correspondence titled “Gut Microbe-Generated Trimethylamine N-Oxide from Dietary Choline is Prothrombotic in Subjects”, published by Zhu et al . in the journal Circulation (1). This work builds on an emerging body of evidence which has suggested a role for the gut-derived metabolite, trimethylamine N -oxide (TMAO), in the ...
Kevin C. Klatt, Marie A. Caudill
openaire   +1 more source

Synthesis and alkyne-coupling chemistry of cyclomanganated 1- and 3-acetylindoles, 3-formylindole and analogues [PDF]

, 2006
The syntheses are reported of new cyclomanganated indole derivatives (1-acetyl-κO-indolyl-κC2)dicarbonylbis(trimethylphosphite)manganese (2), (1-methyl-3-acetyl-κO-indolyl-κC2)tetracarbonylmanganese (4), (3-formyl-κO-indolyl-κC2)tetracarbonylmanganese ...
Depree, Gary J., Jameson, Geoffrey B., Main, Lyndsay, Nicholson, Brian K., Robinson, Nicholas P.   +4 more
core   +2 more sources

Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study

Nutrition & Metabolism, 2020
Background Accumulating evidence shows that circulating levels of trimethylamine N-oxide, which is generated from the metabolism of dietary choline, may predict cardiovascular disease among Caucasians.
Yuxiang Dai, Qianqian Tian, Jing Si, Zhonghan Sun, Shalaimaiti Shali, Lili Xu, Daoyuan Ren, Shufu Chang, Xin Dong, Hongxia Zhao, Zhendong Mei, Yan Zheng, Junbo Ge   +12 more
doaj   +1 more source