Results 91 to 100 of about 10,078 (159)

Investigation of the effect of trimethylamine-N-oxide on the proinflammatory cytokine genes expression in U937-derived macrophages

مجله علمی دانشگاه علوم پزشکی کردستان, 2018
Background and Aim: Atherosclerosis is known as a multifactorial inflammatory disease. Trimethylamine N-oxide (TMAO) as a risk factor, has a potential to trigger or enhance the immune inflammatory reactions in atherosclerosis. Yet, The exact mechanism by
Mohammad Abdi, Zakarya Vahabzadeh, Amin Ghanivash, Leila Farhadi, Mohammad Saeed Hakhamaneshi, Pedram Andalibi   +5 more
doaj  

Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet

Food Science and Human Wellness
Trimethylamine N-oxide (TMAO) is a risk factor of various chronic diseases, which was produced by metabolism from precursors to trimethylamine (TMA) in gut and the oxidation from TMA in liver.
Chengcheng Wang, Xuefeng Duan, Xiaoyue Li, Jinyue Yang, Changhu Xue, Teruyoshi Yanagita, Tiantian Zhang, Yuming Wang   +7 more
doaj   +1 more source

Exploring the trimethylamine pathway in advanced chronic liver disease

npj Gut and Liver
The trimethylamine (TMA)-trimethylamine-N-oxide (TMAO) pathway, involving gut microbiota-derived metabolites, may play a role in advanced chronic liver disease (ACLD).
Jil T. Bürki, Jonas Schropp, Peter Neyer, Christian Steuer, Jaume Bosch, Annalisa Berzigotti, Susana G. Rodrigues   +6 more
doaj   +1 more source

Trimethylamine-N-oxide (TMAO) and the predicted risk of cardiovascular events after partial nephrectomy

Asian Journal of Surgery
Emerging evidence suggests that uremic toxins, in particular trimethylamine-N-oxide(TMAO), indoxyl-sulfate(IS), and p-cresyl-sulfate(PCS), may associate with increased risk of cardiovascular events(CVe). However, whether uremic toxins increase after partial nephrectomy(PN) and their correlation with risk for CVe remains unknown.100 patients managed ...
Xiangpeng Zou, Longbin Xiong, Zhixing Guo, Yuchen Li, Kang Ning, Xiaohua Liu, Ye Xie, Yulu Peng, Yixuan Liu, Xinyang Cai, Boxin Zhao, Fangjian Zhou, Chunping Yu, Xia Zheng, Steven C. Campbell, Zhiling Zhang   +15 more
openaire   +2 more sources

Circulating TMAO, the gut microbiome and cardiometabolic disease risk: an exploration in key precursor disorders

Diabetology & Metabolic Syndrome
Background Elevations in the gut metabolite trimethylamine-N-oxide (TMAO) have been linked to cardiovascular and metabolic diseases. Whether elevated TMAO levels reflect early mechanistic involvement or a sequela of evolving disease awaits elucidation ...
Saba Naghipour, Amanda J. Cox, Joshua J. Fisher, Manuel Plan, Terra Stark, Nic West, Jason N. Peart, John P. Headrick, Eugene F. Du Toit   +8 more
doaj   +1 more source

Monooxygenase-dehydrogenase cascade for sustained enzymatic remediation of TMA in salmon protein hydrolysates

Applied and Environmental Microbiology
Fish protein hydrolysates hold great promise as nutraceuticals, yet their application as food ingredients or nutraceuticals is currently limited by their fish-like odor. This odor is mainly due to the presence of trimethylamine (TMA), a volatile biogenic
Rasmus Ree, Øivind Larsen, Sushil Gaykawad, Sreerekha S. Ramanand, Antonio García-Moyano, Irina Elena Chiriac, Pål Puntervoll, Gro Elin Kjæreng Bjerga   +7 more
doaj   +1 more source

Effects of choline metabolite—trimethylamine N-oxide on immunometabolism in inflammatory bowel disease

Frontiers in Immunology
Trimethylamine N-oxide (TMAO), a key metabolite derived from the gut microbial metabolism of choline, has recently been implicated as a significant contributor to the development of several chronic diseases, including diabetes, cardiovascular disease ...
Siyu Wang, Siyu Wang, Yifan Ni, Shuwei Zhou, Huiping Peng, Huiping Peng, Ying Cao, Yue Zhu, Jing Gong, Qiulu Lu, Zhongyu Han, Yumeng Lin, Yaodong Wang, Yaodong Wang   +13 more
doaj   +1 more source

Time-dependent specific molecular signatures of inflammation and remodelling are associated with trimethylamine-N-oxide (TMAO)-induced endothelial cell dysfunction. [PDF]

Sci Rep, 2023
Shanmugham M, Devasia AG, Chin YL, Cheong KH, Ong ES, Bellanger S, Ramasamy A, Leo CH.   +7 more
europepmc   +1 more source

Trimethylamine N-oxide (TMAO) for risk stratification after acute ischemic stroke: Results from the BIOSIGNAL cohort study. [PDF]

Eur Stroke J
Frenger J, Jeker B, Arnold M, Grosse GM, Pokorny T, Westphal LP, Inauen C, Bicciato G, Arnold M, Fischer U, De Marchis GM, Kägi G, Kahles T, Cereda CW, Bustamante A, Montaner J, Ntaios G, Foerch C, Spanaus K, von Eckardstein A, Mueller D, Katan M.   +21 more
europepmc   +2 more sources

Gut-Derived Metabolite, Trimethylamine-N-oxide (TMAO) in Cardio-Metabolic Diseases: Detection, Mechanism, and Potential Therapeutics. [PDF]

Pharmaceuticals (Basel), 2023
Shanmugham M, Bellanger S, Leo CH.
europepmc   +1 more source