Results 81 to 90 of about 11,599 (170)

Nano-functionalized probiotic treats atherosclerosis via inhibiting intestinal microbiota-TMA-TMAO axis

Nature Communications
Many patients are suffering from atherosclerosis without typical risk factors, which can cause severe cardiovascular complications. Trimethylamine N-oxide (TMAO), derived from gut microbes, is a key unconventional contributor to the development of ...
Zhezhe Chen, Qiongjun Zhu, Hong Xu, Yiqing Hu, Yanan Wang, Zhebin Chen, Yao Wang, Xingru Huang, Guosheng Fu, Boxuan Ma, Wenbin Zhang   +10 more
doaj   +1 more source

Metabolic Changes During a Calorie‐Restricted, Fish‐Rich Ketogenic Diet Associated With Increased Circulating TMAO in Healthy Adults

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
A 2‐week calorie‐restricted, fish‐rich ketogenic diet increased circulating TMAO while improving selected glycemic and insulin‐related biomarkers in healthy adults. HDL cholesterol decreased, whereas oxidative stress markers remained unchanged, highlighting a complex short‐term metabolic response that should not be interpreted as evidence of causality.
Katarzyna Siedzik, Kamil Góral, Damian Flis, Maciej Jaguszewski, Robert A. Olek, Wiesław Ziółkowski   +5 more
wiley   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

The association of plasma TMAO and body composition with the occurrence of PEW in maintenance hemodialysis patients

Renal Failure
Introduction This study aims to explore the relationship between trimethylamine N-oxide (TMAO), body composition, and protein-energy wasting (PEW) in patients undergoing maintenance hemodialysis (MHD).Methods A total of 127 MHD patients participated in ...
Xinran Wang, Xinyue Peng, Jun Liu, Shiqi Tang, Xinyu Yang, Jianwen Wang   +5 more
doaj   +1 more source

Effects of Weight Loss Interventions on Gut Microbiota‐Derived Metabolites Linked to Cardiometabolic Health: A Systematic Review and Meta‐Analysis

Obesity Reviews, Volume 27, Issue 11, November 2026.
ABSTRACT Background Gut microbiota‐derived metabolites are emerging as potential mediators between obesity and cardiometabolic conditions. While weight loss interventions modify microbiota composition, their effects on systemic microbial metabolites remain unclear.
Fernando Q. Iorra, Leonardo André Swarowsky Loebens, Andrea Auler, Eduarda Caroline Tasso Nascimento, Beatriz D. Schaan, Patrícia Martins Bock   +5 more
wiley   +1 more source

Gut Microbiota-Derived Trimethylamine N-Oxide and NT-proBNP in Heart Failure: A Critical Review of Diagnostic and Prognostic Value

Biomedicines
Objective: The study aims to evaluate the diagnostic and prognostic efficacy of gut-derived trimethylamine N-oxide (TMAO) as a molecular biomarker for heart failure (HF) in comparison to the N-terminal pro-B-type natriuretic peptide.
Natalia Anna Suchecka, Patrycja Popławska, Patrycja Obrycka, Agnieszka Frątczak, Ewa Tokarz, Julia Soczyńska, Sławomir Woźniak   +6 more
doaj   +1 more source

Intestinal Microbiota Metabolism and Atherosclerosis

Chinese Medical Journal, 2015
Objective: This review aimed to summarize the relationship between intestinal microbiota metabolism and cardiovascular disease (CVD) and to propose a novel CVD therapeutic target.
Tian-Xing Liu, Hai-Tao Niu, Shu-Yang Zhang   +2 more
doaj   +1 more source

Trimethylamine N-Oxide (TMAO) and Atherosclerosis

This monograph provides a concise overview of the emerging role of trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, in the pathogenesis of atherosclerosis. It reviews the molecular mechanisms linking TMAO with endothelial dysfunction, vascular inflammation, and atherogenesis, together with current and emerging TMAO-targeted ...
openaire   +2 more sources

Trimethylamine-N-oxide (TMAO) increased aquaporin-2 expression in spontaneously hypertensive rats

Clinical and Experimental Hypertension, 2018
Recent evidence suggests that elevated plasma levels of Trimethylamine-N-oxide (TMAO) can prolong the duration of elevated blood pressure in rats. The purpose of this study was to investigate the plasma TMAO level in Spontaneously Hypertensive Rats (SHR) and to explore the possible relationship between TMAO and aquaporin-2 (AQP-2) in the formation of ...
Min Liu, Qinghua Han, Jinglu Yang
openaire   +3 more sources

Research progress on the association between TMAO and vascular calcification in patients with chronic kidney disease

Renal Failure
Vascular calcification (VC) is a common complication in patients with chronic kidney disease (CKD) and a major risk factor for increased cardiovascular mortality in patients with CKD.
Yuxin Zhang, Liangying Huang, Santao Ou
doaj   +1 more source