Results 91 to 100 of about 11,599 (170)

Raman Spectroscopic Signatures of Noncovalent Interactions Between Trimethylamine N-oxide (TMAO) and Water

The Journal of Physical Chemistry B, 2011
The effects of hydration on vibrational normal modes of trimethylamine N-oxide (TMAO) are investigated by Raman spectroscopy and electronic structure computations. Microsolvated networks of water are observed to induce either red or blue shifts in the normal modes of TMAO with increasing water concentration and to also exhibit distinct spectral ...
Katherine L, Munroe, David H, Magers, Nathan I, Hammer   +2 more
openaire   +2 more sources

β-cell FMO3-produced TMAO prevents NF-κB-mediated senescence and inflammation in ageing and diabetic conditions

Nature Communications
Human cells utilize gut microbiota-derived metabolites to control systemic metabolism. Trimethylamine N-oxide (TMAO) is traditionally considered a hepatocyte-derived metabolite from microbial trimethylamine.
Baomin Wang, Yumei Yang, Yuen Man Ho, Huige Lin, Juntao Yuan, Kekao Long, Kenneth King Yip Cheng, Xiaomu Li   +7 more
doaj   +1 more source

The Gut Microbial-Derived Metabolite Trimethylamine N-Oxide and Atrial Fibrillation: Relationships, Mechanisms, and Therapeutic Strategies

Clinical Interventions in Aging, 2021
Rui Huang,1,* Li Yan,2,* Yuhua Lei1 1Cardiovascular Disease Center, Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi Prefecture, 445000, Hubei Province, People’s Republic of China ...
Huang R, Yan L, Lei Y
doaj  

Increased circulating trimethylamine N-oxide plays a contributory role in the development of endothelial dysfunction and hypertension in the RUPP rat model of preeclampsia

Hypertension in Pregnancy, 2019
Objective: We examined whether trimethylamine-N-oxide (TMAO) plays a role in endothelial dysfunction and hypertension in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia (PE).
Hui Chen, Jiabao Li, Ning Li, Hongsheng Liu, Jiyun Tang   +4 more
doaj   +1 more source

Investigation of the effect of trimethylamine-N-oxide on the proinflammatory cytokine genes expression in U937-derived macrophages

مجله علمی دانشگاه علوم پزشکی کردستان, 2018
Background and Aim: Atherosclerosis is known as a multifactorial inflammatory disease. Trimethylamine N-oxide (TMAO) as a risk factor, has a potential to trigger or enhance the immune inflammatory reactions in atherosclerosis. Yet, The exact mechanism by
Mohammad Abdi, Zakarya Vahabzadeh, Amin Ghanivash, Leila Farhadi, Mohammad Saeed Hakhamaneshi, Pedram Andalibi   +5 more
doaj  

Trimethylamine N-oxide generation process was influenced by the proportion and source of macronutrients in the diet

Food Science and Human Wellness
Trimethylamine N-oxide (TMAO) is a risk factor of various chronic diseases, which was produced by metabolism from precursors to trimethylamine (TMA) in gut and the oxidation from TMA in liver.
Chengcheng Wang, Xuefeng Duan, Xiaoyue Li, Jinyue Yang, Changhu Xue, Teruyoshi Yanagita, Tiantian Zhang, Yuming Wang   +7 more
doaj   +1 more source

Exploring the trimethylamine pathway in advanced chronic liver disease

npj Gut and Liver
The trimethylamine (TMA)-trimethylamine-N-oxide (TMAO) pathway, involving gut microbiota-derived metabolites, may play a role in advanced chronic liver disease (ACLD).
Jil T. Bürki, Jonas Schropp, Peter Neyer, Christian Steuer, Jaume Bosch, Annalisa Berzigotti, Susana G. Rodrigues   +6 more
doaj   +1 more source

Circulating TMAO, the gut microbiome and cardiometabolic disease risk: an exploration in key precursor disorders

Diabetology & Metabolic Syndrome
Background Elevations in the gut metabolite trimethylamine-N-oxide (TMAO) have been linked to cardiovascular and metabolic diseases. Whether elevated TMAO levels reflect early mechanistic involvement or a sequela of evolving disease awaits elucidation ...
Saba Naghipour, Amanda J. Cox, Joshua J. Fisher, Manuel Plan, Terra Stark, Nic West, Jason N. Peart, John P. Headrick, Eugene F. Du Toit   +8 more
doaj   +1 more source

Clinical significance of gut microbiota-derived metabolite trimethylamine N-oxide in patients with systemic lupus erythematosus

Scientific Reports
Trimethylamine N-oxide (TMAO), a gut microbiota-derived metabolite, is associated with cardiovascular disease (CVD) via pro-inflammatory and pro-atherogenic mechanisms.
Jiwon Yang, Youngjae Park, Se Gwang Jang, Min-Jung Park, Su-Jin Moon, Hyung-Kyoon Choi, Seung-Ki Kwok   +6 more
doaj   +1 more source

Time-dependent specific molecular signatures of inflammation and remodelling are associated with trimethylamine-N-oxide (TMAO)-induced endothelial cell dysfunction. [PDF]

Sci Rep, 2023
Shanmugham M, Devasia AG, Chin YL, Cheong KH, Ong ES, Bellanger S, Ramasamy A, Leo CH.   +7 more
europepmc   +1 more source