Results 111 to 120 of about 19,697 (197)
Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design
Journal of Structural Biology: XTripartite motif (TRIM) proteins constitute one of the largest subfamilies of RING-type E3 ubiquitin ligases and are attractive targets for the development of novel degraders that exploit the ubiquitin–proteasome pathway.
Rezart Zhubi +4 more
doaj +1 more source
Journal of Medical Virology, Volume 98, Issue 8, August 2026.ABSTRACT Coronavirus disease 2019 (COVID‐19) survivors frequently experience a wide range of symptoms known as post‐acute sequelae of SARS‐CoV‐2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood‐brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the ...
Arpan Acharya +7 more
wiley +1 more source
The B30.2/SPRY-Domain: A Versatile Binding Scaffold in Supramolecular Assemblies of Eukaryotes
CrystalsB30.2 domains, sometimes referred to as PRY/SPRY domains, were originally identified by sequence profiling methods at the gene level. The B30.2 domain comprises a concanavalin A-like fold consisting of two twisted seven-stranded anti-parallel β-sheets ...
Peer R. E. Mittl, Hans-Dietmar Beer
doaj +1 more source
Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives
MedComm, Volume 7, Issue 8, August 2026.The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng +9 more
wiley +1 more source
Nucleotide Metabolism in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao +7 more
wiley +1 more source
Protein Science, Volume 35, Issue 8, August 2026.Abstract The spatial and energetic encoding of allosteric regulatory sites remains a major challenge in structural biology, frequently representing a “blind spot” for sequence‐based artificial intelligence (AI) models. We present a protein language model (PLM)‐guided approach complemented by the energy landscape frustration analysis as a dual‐stream ...
Will Gatlin +8 more
wiley +1 more source
Deciphering the Functional Mechanisms of eIF3f in Tumors and Exploring Targeted Therapies
Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.ABSTRACT Eukaryotic translation initiation factor 3 subunit F (eIF3f) is a critical component of the eIF3 complex and plays a pivotal role in diverse biological processes, including cell proliferation, apoptosis, adhesion, and transcriptional regulation.
Yujinpeng Hao +3 more
wiley +1 more source
Aging Cell, Volume 25, Issue 8, August 2026.In Alzheimer's disease, SIRT5 downregulation enhances TRIM25‐mediated succinylation of HNRNPC at K50, increasing its stability. Stabilized HNRNPC upregulates YME1L1 expression via an m6A‐dependent mechanism, leading to OPA1 hydrolysis dysregulation, mitochondrial fission‐fusion imbalance, ROS overproduction, and neuronal death.
Xuewei Li +4 more
wiley +1 more source