Results 141 to 150 of about 4,709 (168)

Tripartite motif-containing (TRIM) 21 negatively regulates intestinal mucosal inflammation through inhibiting TH1/TH17 cell differentiation in patients with inflammatory bowel diseases

Journal of Allergy and Clinical Immunology, 2018
Tripartite motif-containing (TRIM) 21 has been implicated in the pathogenesis of several types of autoimmune diseases.We sought to elucidate TRIM21 expression in patients with inflammatory bowel diseases (IBDs) and its role in regulating intestinal mucosal inflammation.TRIM21 expression was analyzed in the inflamed mucosa of patients with IBDs by means
Guangxi Zhou, Wei Wu, Lin Yu, Tianming Yu, Wenjing Yang, Ping Wang, Xiaoping Zhang, Yingzi Cong, Zhanju Liu   +8 more
openaire   +2 more sources

Tripartite motif (TRIM) proteins roles in the regulation of immune system responses: Focus on autoimmune diseases

Experimental Cell Research
The tripartite motif (TRIM) proteins are well-studied as essential modulators of many processes, including the modulation of several pathways linked to immunological reactions. Most TRIM family members can polyubiquitinate the targeted proteins by acting as E3 ubiquitin ligases. According to current research, TRIMs play a critical role in innate immune
Subasini Uthirapathy, Abdulrahman T. Ahmed, Mahmood Jawad, Vicky Jain, Suhas Ballal, Hussein Riyadh Abdul Kareem Al-Hetty, Gaurav Khandelwal, Renu Arya, null Muthena kariem, Yasser Fakri Mustafa   +9 more
openaire   +2 more sources

MyoTRIM, an engineered tripartite motif (TRIM) protein, recapitulates canonical phosphatidylserine binding and enhances cell membrane resealing capacity

Physiology
Duchenne Muscular Dystrophy (DMD) is the most prevalent hereditary neuromuscular disease and involves progressive muscle degeneration that contributes to early death. DMD is caused by mutations in the dystrophin gene, which eliminates its expression and leads to compromised structural integrity of the muscle cell plasma membrane.
Miguel A. Lopez Perez, Kassidy K. Banford, Hannah R. Bulgart, Gianni Giarrano, Noah Weisleder   +4 more
openaire   +1 more source

Human immunodeficiency virus type 1 restriction by human-rhesus chimeric tripartite motif 5alpha (TRIM 5alpha) in CD34(+) cell-derived macrophages in vitro and in T cells in vivo in severe combined immunodeficient (SCID-hu) mice transplanted with human fetal tissue.

Human gene therapy, 2008
Species-specific innate resistance against viral infections offers novel avenues for antiviral therapeutics. The retroviral restriction factor TRIM5alpha (tripartite motif 5alpha protein) has been shown to potently restrict human immunodeficiency virus (HIV)-1 infection in otherwise susceptible cell lines and CD34(+) cell-derived macrophages.
Joseph, Anderson, Ramesh, Akkina
openaire   +2 more sources

TRIM family proteins: retroviral restriction and antiviral defence

Nature Reviews Microbiology, 2005
Sébastien Nisole, Jonathan P Stoye
exaly  

127 Characterization of Tripartite-Motif (TRIM) 22-Mediated Inhibition of HIV-1 Transcription

JAIDS Journal of Acquired Immune Deficiency Syndromes, 2011
A Kajaste-Rudnitski, S Marell, T Pertel, G Poli, J Luban, E Vicenzi   +5 more
openaire   +1 more source

Restriction of HIV-1 and other retroviruses by TRIM5

Nature Reviews Microbiology, 2019
Barbie K Ganser-Pornillos, Owen Pornillos   +1 more
exaly  

TRIM (tripartite interaction motif)

2008
openaire   +1 more source

TRIM proteins and cancer

Nature Reviews Cancer, 2011
Shigetsugu Hatakeyama
exaly  

Author response for "Role of the tripartite motif-containing (TRIM) family of proteins in insulin resistance and related disorders"

2023
null Chen, Jianrong, null Feng, Xianjie, null Zhou, Xu, null Li, Yong   +3 more
openaire   +1 more source