RNA triphosphatase-mediated mRNA capping is essential for maintaining transcript homeostasis and the survival of Toxoplasma gondii [PDF]
Nature CommunicationsRNA modifications are crucial for gene expression in eukaryotes; however, the regulatory role of 5’ 7-methylguanosine (m7G) cap, the first modification of mRNA, remains unknown in the protozoan parasite Toxoplasma gondii.
Kalyani R. Aswale +2 more
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NTPase and 5'-RNA triphosphatase activities of Chikungunya virus nsP2 protein. [PDF]
PLoS ONE, 2011 Chikungunya virus (CHIKV) is an insect borne virus (genus: Alphavirus) which causes acute febrile illness in humans followed by a prolonged arthralgic disease that affects the joints of the extremities.
Yogesh A Karpe +2 more
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Reassessing the Mechanisms of PLN-R14del Cardiomyopathy [PDF]
JACC: Basic to Translational ScienceSummary: The phospholamban (PLN) pathogenic gene variant, p.Arg14del (PLN-R14del), can lead to dilated and arrhythmogenic cardiomyopathy, resulting in heart failure.
Nienke M. Stege, MSc +4 more
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Hydrogen peroxide yields mechanistic insights into human mRNA capping enzyme function. [PDF]
PLoS ONE, 2017 Capping of nascent RNA polymerase II (Pol II) transcripts is required for gene expression and the first two steps are catalyzed by separate 5' triphosphatase and guanylyltransferase activities of the human capping enzyme (HCE).
Nicholas J Mullen, David H Price
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Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
wiley +1 more source
Properties of chicken liver membrane-associated thiamine triphosphatase [PDF]
The Ukrainian Biochemical Journal, 2015 The enzymes involved in thiamine triphosphate (ThTP) metabolism in birds are not characterized so far. The aim of the present work was to study some properties of ThTPase in chicken liver.
I. K. Kolas, A. F. Makarchikov
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Halobacterial adenosine triphosphatases and the adenosine triphosphatase fromHalobacterium saccharovorum [PDF]
FEMS Microbiology Letters, 1986 Membranes prepared from various members of the genus Halobacterium contained a Triton X-100 activated adenosine triphosphatase. The enzyme from Halobacterium saccharovorum was unstable in solutions of low ionic strength (< 3 M NaCl) and maximally active in the presence of 3.5 M NaCl. A variety of nucleotide triphosphates was hydrolyzed.
H, Kristjansson +2 more
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Enzyme kinetics of deoxyuridine triphosphatase from Western corn rootworm
BMC Research Notes, 2023 Objective The Western corn rootworm (WCR), Diabrotica virgifera virgifera, is a highly adaptable insect pest that has evolved resistance to a variety of control strategies, including insecticides.
Carlos Riera-Ruiz, Hideaki Moriyama
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Animals, 2022 Kirsten rat sarcoma viral oncogene homolog (KRAS), or guanosine triphosphatase KRAS, is a proto-oncogene that encodes the small guanosine triphosphatase transductor protein.
Wenjie Yu +13 more
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Erythrocyte inosine triphosphatase activity is decreased in HIV-seropositive individuals. [PDF]
PLoS ONE, 2012 BACKGROUND:Inosine triphosphatase (ITPase) is encoded by the polymorphic gene ITPA and maintains low intracellular levels of the inosine nucleotides ITP and dITP. The most frequently reported polymorphisms are ITPA c.94C>A (rs 1127354) and ITPA c. 124+21
Jörgen Bierau +7 more
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