Results 31 to 40 of about 56,477 (262)

Structural and Functional Studies of Chikungunya Virus nsP2

Proceedings, 2020
Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes Chikungunya fever. Nonstructural protein 2 (nsP2) contains an N-terminal RNA helicase with both nucleotide triphosphatase and RNA triphosphatase activities, and a C-terminal
Yee Song Law, Yaw Bia Tan, Orion Shih, Age Utt, Jie Zheng, Sainan Wang, Ming Wei Chen, Patrick R. Griffin, U-Ser Jeng, Andres Merits, Dahai Luo   +10 more
doaj   +1 more source

Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins

Computational and Structural Biotechnology Journal, 2021
In plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes.
Junrui Zhang, Alexandra I. Vancea, Umar F. Shahul Hameed, Stefan T. Arold   +3 more
doaj   +1 more source

Infectious diseases and autoimmunity [PDF]

, 2011
Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia, Delitala, Giuseppe, Delogu, Lucia Gemma, Manetti, Roberto   +3 more
core   +1 more source

RNA 5′-Triphosphatase, Nucleoside Triphosphatase, and Guanylyltransferase Activities of Baculovirus LEF-4 Protein [PDF]

Journal of Virology, 1998
ABSTRACT Autographa californica nuclear polyhedrosis virus late and very late mRNAs are transcribed by an RNA polymerase consisting of four virus-encoded polypeptides: LEF-8, LEF-9, LEF-4, and p47. The 464-amino-acid LEF-4 subunit contains the signature motifs of GTP:RNA guanylyltransferases (capping enzymes).
C H, Gross, S, Shuman
openaire   +2 more sources

Dynein structure and power stroke [PDF]

, 2003
Dynein ATPases are microtubule motors that are critical to diverse processes such as vesicle transport and the beating of sperm tails; however, their mechanism of force generation is unknown.
A Elliot, AF Neuwald, CK Omoto, DJ Asai, DM Woolley, G Mocz, G Mocz, GG Vernon, H Sakakibara, IR Gibbons, IR Gibbons, IR Gibbons, IR Gibbons, IR Gibbons, J Fan, J Frank, K Ogawa, K Shiroguchi, KA Johnson, LM DiBella, M Okuno, M Samsó, MA Gee, MA Gee, ML Walker, MP Koonce, MP Koonce, RB Vallee, RD Vale, RD Vale, RD Vale, S Karki, SA Burgess, SA Burgess, SM King, SM King, T Yagi, UW Goodenough, UW Goodenough, UW Goodenough, UW Goodenough   +40 more
core   +1 more source

Type I Collagen Receptor (α2β1) Signaling Promotes Prostate Cancer Invasion through RhoC GTPase

Neoplasia: An International Journal for Oncology Research, 2008
The most frequent site of metastasis in human prostate cancer (PCa) is the bone. Preferential adhesion of PCa cells to bone-specific factors may facilitate the selective metastasis of the skeleton.
Christopher L. Hall, Cara W. Dubyk, Tracy A. Riesenberger, Daniel Shein, Evan T. Keller, Kenneth L. van Golen   +5 more
doaj   +1 more source

Late-onset thymidine kinase 2 deficiency: a review of 18 cases [PDF]

, 2019
BACKGROUND: TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the 'myopathic form' of the mitochondrial depletion ...
Caballero Eraso, Candelaria, Domínguez González, Cristina, Fernández Torrón, Roberto, Fuiza Luces, Carmen, García García, Jorge M., Hernández Laín, Aurelio, Hernández Voth, Ana R., Paradas, Carmen, Rivas, Eloy, Sayas Catalán, Javier   +9 more
core   +1 more source

Adenosine triphosphatase staining of dermatophytes

Acta Dermato-Venereologica, 1971
No abstract ...
W B, Shelley, L, Juhlin
openaire   +2 more sources

Plasmodium RNA triphosphatase validation as antimalarial target

International Journal for Parasitology: Drugs and Drug Resistance
Target-based approaches have traditionally been used in the search for new anti-infective molecules. Target selection process, a critical step in Drug Discovery, identifies targets that are essential to establish or maintain the infection, tractable to ...
Sonia Moliner-Cubel, Noemi Bahamontes-Rosa, Ane Rodriguez-Alejandre, Pamela M. Nassau, Argyrides Argyrou, Anshu Bhardwaja, Rachel C. Buxton, David Calvo-Vicente, Bernadette Mouzon, William McDowell, Alfonso Mendoza-Losana, Maria G. Gomez-Lorenzo   +11 more
doaj   +1 more source

Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome ActivationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Ral guanosine triphosphatase–activating protein α2 (RalGAPα2) is the major catalytic subunit of the negative regulators of the small guanosine triphosphatase Ral, a member of the Ras subfamily.
Tomoya Iida, Daisuke Hirayama, Naoki Minami, Minoru Matsuura, Kohei Wagatsuma, Kentaro Kawakami, Kanna Nagaishi, Masanori Nojima, Hiroki Ikeuchi, Seiichi Hirota, Ryutaro Shirakawa, Hisanori Horiuchi, Hiroshi Nakase   +12 more
doaj   +1 more source