Results 31 to 40 of about 57,313 (306)

Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase

mBio, 2016
Eukaryal taxa differ with respect to the structure and mechanism of the RNA triphosphatase (RTPase) component of the mRNA capping apparatus. Protozoa, fungi, and certain DNA viruses have a metal-dependent RTPase that belongs to the triphosphate tunnel ...
Paul Smith, C. Kiong Ho, Yuko Takagi, Hakim Djaballah, Stewart Shuman   +4 more
doaj   +1 more source

Infectious diseases and autoimmunity [PDF]

, 2011
Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia, Delitala, Giuseppe, Delogu, Lucia Gemma, Manetti, Roberto   +3 more
core   +1 more source

Hepatitis C virus pharmacogenomics in Latin American populations: implications in the era of direct-acting antivirals [PDF]

, 2017
In recent years, great progress has been made in the field of new therapeutic options for hepatitis C virus (HCV) infection. The new direct-acting antiviral agents (DAAs) represent a great hope for millions of chronically infected individuals because ...
Caputo, Mariela, Corach, Daniel, Flichman, Diego Martin, Hulaniuk, María L., Trinks, Julieta   +4 more
core   +1 more source

The guanylate-binding proteins: emerging insights into the biochemical properties and functions of this family of large interferon-induced guanosine triphosphatase.

Journal of Interferon and Cytokine Research, 2011
Originally identified by their unusual ability to bind guanosine monophosphate (GMP) nucleotide agarose, the guanylate-binding proteins (GBPs) were used extensively to promote our understanding of interferon-induced gene transcription and as markers of ...
D. Vestal, Jonathan A. Jeyaratnam
semanticscholar   +1 more source

Structural and Functional Studies of Chikungunya Virus nsP2

Proceedings, 2020
Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes Chikungunya fever. Nonstructural protein 2 (nsP2) contains an N-terminal RNA helicase with both nucleotide triphosphatase and RNA triphosphatase activities, and a C-terminal
Yee Song Law, Yaw Bia Tan, Orion Shih, Age Utt, Jie Zheng, Sainan Wang, Ming Wei Chen, Patrick R. Griffin, U-Ser Jeng, Andres Merits, Dahai Luo   +10 more
doaj   +1 more source

Designing New Natural‐Mimetic Phosphatidic Acid: A Versatile and Innovative Synthetic Strategy for Glycerophospholipid Research

Angewandte Chemie, EarlyView.
We report the role of the fatty acyl chains in biological activities of phosphatidic acids (PA). Several PA probes having two different fatty acyl chains were synthesized through a multi‐steps synthesis and bearing various fluorophores or photo‐cross‐linkers (PCL).
Antoine Schlichter, Alexander Wolf, Thomas Ferrand, Aurelien Cocq, Lina Riachy, Steven Vertueux, Brice Beauvais, Marine Courvalet, Paul‐Joël Henry, Emeline Tanguy, Louis Gonzales, Rémy Ferlet, Fanny Laguerre, Charles Decraene, Alexia Pellissier, Muriel Sebban, Cyrille Sabot, Lydie Jeandel, Sarah Cianférani, Jean‐Marc Strub, Magalie Bénard, Victor Flon, Valérie Peulon‐Agasse, Pascal Cardinael, Stéphane Ory, Stéphane Gasman, Pierre‐Yves Renard, Maïté Montero‐Hadjadje, Nicolas Vitale, Sébastien Balieu   +29 more
wiley   +2 more sources

Molecular Characterization of Protease Activity in Serratia sp. Strain SCBI and Its Importance in Cytotoxicity and Virulence [PDF]

, 2014
A newly recognized Serratia species, termed South African Caenorhabditis briggsae isolate (SCBI), is both a mutualist of the nematode Caenorhabditis briggsae KT0001 and a pathogen of lepidopteran insects. Serratia sp.
Petersen, Lauren M., Tisa, Louis S.
core   +2 more sources

Single nucleotide polymorphisms that increase expression of the guanosine triphosphatase RAC1 are associated with ulcerative colitis.

Gastroenterology, 2011
BACKGROUND & AIMS RAC1 is a guanosine triphosphatase that has an evolutionarily conserved role in coordinating immune defenses, from plants to mammals. Chronic inflammatory bowel diseases are associated with dysregulation of immune defenses.
A. Muise, T. Walters, W. Xu, Grace Shen-Tu, C. Guo, Ramzi Fattouh, G. Lam, V. Wolters, Joshua Bennitz, J. V. van Limbergen, P. Renbaum, Yair Kasirer, B. Ngan, D. Turner, L. Denson, P. Sherman, R. Duerr, Judy H. Cho, C. Lees, J. Satsangi, D. Wilson, A. Paterson, A. Griffiths, M. Glogauer, M. Silverberg, J. Brumell   +25 more
semanticscholar   +1 more source

Crystallization of Chlorella deoxyuridine triphosphatase [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2011
Deoxyuridine triphosphatase (dUTPase) is a ubiquitous enzyme that has been widely studied owing to its function and evolutionary significance. The gene coding for the dUTPase from the Chlorella alga was codon-optimized and synthesized. The synthetic gene was expressed in Escherichia coli and recombinant core Chlorella dUTPase (chdUTPase) was purified ...
Badalucco, Laura, Poudel, Ishwari, Yamanishi, Mamoru, Natarajan, Chandrasekhar, Moriyama, Hideaki   +4 more
openaire   +3 more sources

Complete genome sequence and taxonomic position of anguillid herpesvirus 1 [PDF]

, 2010
Eel herpesvirus or anguillid herpesvirus 1 (AngHV1) frequently causes disease in freshwater eels. The complete genome sequence of AngHV1 and its taxonomic position within the family Alloherpesviridae were determined. Shotgun sequencing revealed a 249 kbp
Abma-Henkens, M.H.C., Beurden, S.J., van, Bossers, A., Engelsma, M.Y., Haenen, O.L.M., Peeters, B.P.H., Peters, S.A., Rottier, P.J.M., Voorbergen-Laarman, H.A.   +8 more
core   +3 more sources