: Background: Although dopamine D2 receptor agonists, bromocriptine and cabergoline, are notable medications in the treatment of Parkinsonism, hyperprolactinemia, and hyperglycemia, there is an identified relationship between the utilization of D2-like ...
Mohammed Fouad Shalaby, MD +5 more
doaj +1 more source
Inhibition and relaxation of sea urchin sperm flagella by vanadate [PDF]
Direct measurements of the stiffness (elastic bending resistance) of demembranated sera urchin sperm flagella were made in the presence of MgATP2- and vanadate.
Okuno, Makoto
core +3 more sources
Yeast and Viral RNA 5′ Triphosphatases Comprise a New Nucleoside Triphosphatase Family [PDF]
Saccharomyces cerevisiae Cet1p catalyzes the first step of mRNA capping, the hydrolysis of the gamma phosphate of triphosphate-terminated RNA to form a 5' diphosphate end. The RNA triphosphatase activity of Cet1p is magnesium-dependent and has a turnover number of 1 s-1.
Stewart Shuman, Yi Pei, C. K. Ho
openaire +3 more sources
Effects of cellular cholesterol loading on macrophage foam cell lysosome acidifications⃞
Macrophages incubated with mildly oxidized low density lipoprotein (OxLDL), aggregated low density lipoprotein (AggLDL), or cholesteryl ester-rich lipid dispersions (DISPs) accumulate cholesterol in lysosomes followed by an inhibition of lysosomal ...
Brian E. Cox +3 more
doaj +1 more source
Structural and Functional Studies of Chikungunya Virus nsP2
Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes Chikungunya fever. Nonstructural protein 2 (nsP2) contains an N-terminal RNA helicase with both nucleotide triphosphatase and RNA triphosphatase activities, and a C-terminal
Yee Song Law +10 more
doaj +1 more source
Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins
In plants, AAA-adenosine triphosphatase (ATPase) Cell Division Control Protein 48 (CDC48) uses the force generated through ATP hydrolysis to pull, extract, and unfold ubiquitylated or sumoylated proteins from the membrane, chromatin, or protein complexes.
Junrui Zhang +3 more
doaj +1 more source
Hepatitis C virus pharmacogenomics in Latin American populations: implications in the era of direct-acting antivirals [PDF]
In recent years, great progress has been made in the field of new therapeutic options for hepatitis C virus (HCV) infection. The new direct-acting antiviral agents (DAAs) represent a great hope for millions of chronically infected individuals because ...
Caputo, Mariela +4 more
core +1 more source
Molecular Characterization of Protease Activity in Serratia sp. Strain SCBI and Its Importance in Cytotoxicity and Virulence [PDF]
A newly recognized Serratia species, termed South African Caenorhabditis briggsae isolate (SCBI), is both a mutualist of the nematode Caenorhabditis briggsae KT0001 and a pathogen of lepidopteran insects. Serratia sp.
Petersen, Lauren M., Tisa, Louis S.
core +2 more sources
Crystallization of Chlorella deoxyuridine triphosphatase [PDF]
Deoxyuridine triphosphatase (dUTPase) is a ubiquitous enzyme that has been widely studied owing to its function and evolutionary significance. The gene coding for the dUTPase from the Chlorella alga was codon-optimized and synthesized. The synthetic gene was expressed in Escherichia coli and recombinant core Chlorella dUTPase (chdUTPase) was purified ...
Badalucco, Laura +4 more
openaire +3 more sources
The effects of calcium and magnesium ions on the adenosine triphosphatase and inosine triphosphatase activities of myosin A [PDF]
1. The effects of Ca2+ and Mg2+ on the enzymic activity of myosin were studied with myosin preparations treated by the ion-exchange resin Chelex-100. A reaction mixture containing 0·05m-potassium chloride was chosen in which the effects of univalent ions such as K+, Na+ and Cl− do not change significantly with small variations in their concentrations ...
T. Nihei, E. A. Sugden
openaire +3 more sources

