Results 111 to 120 of about 3,877 (200)
FEBS Open Bio, 2018 Adiponectin exhibits potent antitumor activities. Herein, we examined the molecular mechanisms underlying suppression of tumor growth by globular adiponectin (gAcrp).
Nirmala Tilija Pun +4 more
doaj +1 more source
Nature Communications, 2017 IL-27 is one of a number of cytokines that can induce antitumour CD8+ T cell responses. Here the authors show that TTP, encoded by Zfp36, degrades p28 to inhibit IL-27 production by macrophages and is thereby a negative regulator of the antitumour ...
Qinghong Wang +6 more
doaj +1 more source
Tristetraprolin suppresses AHRR expression through mRNA destabilization
FEBS Letters, 2013 The aryl hydrocarbon receptor repressor (AHRR) inhibits the transcription of the aryl hydrocarbon receptor (AHR) by binding to XRE. We report that AHRR expression is inhibited by tristetraprolin (TTP), an AU‐rich element (ARE)‐binding protein. Overexpression of TTP decreased the mRNA stability and protein expression of AHRR, and TTP‐overexpressing ...
Lee, Hyun Hee +6 more
openaire +2 more sources
PLoS Genetics, 2012 TNF expression of macrophages is under stringent translational control that depends on the p38 MAPK/MK2 pathway and the AU-rich element (ARE) in the TNF mRNA. Here, we elucidate the molecular mechanism of phosphorylation-regulated translation of TNF.
Christopher Tiedje +7 more
doaj +1 more source
Protocol to distinguish pre-mRNA from mRNA in RNA-protein interaction studies
STAR ProtocolsSummary: Transcriptome-wide studies on interactions between RNA-binding proteins (RBPs) and protein-coding RNAs in general preclude interpretations regarding RBP preference for binding to the more abundant mRNA over the less abundant pre-mRNA.
Christina Zeiler +2 more
doaj +1 more source
Post‐transcriptional control of immune responses and its potential application
Clinical & Translational Immunology, 2019 Inflammation is the host response against stresses such as infection. Although the inflammation process is required for the elimination of pathogens, uncontrolled inflammation leads to tissue destruction and inflammatory diseases.
Masanori Yoshinaga, Osamu Takeuchi
doaj +1 more source
Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
A masked PY-NLS in Drosophila TIS11 and its mammalian homolog tristetraprolin.
PLoS ONE, 2013 Many RNA-binding proteins (RBPs) dynamically shuttle between the nucleus and the cytoplasm, often exerting different functions in each compartment. Therefore, the nucleo-cytoplasmic distribution of RBPs has a strong impact on their activity.
Laure Twyffels +5 more
doaj +1 more source