Results 91 to 100 of about 3,877 (200)

Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice

Redox Biology, 2020
Tristetraprolin (TTP), an mRNA binding and decaying protein, plays a significant role in controlling inflammation by decaying mRNAs encoding inflammatory cytokines such as TNFalpha.
Fatma Saaoud, Junfeng Wang, Stephen Iwanowycz, Yuzhen Wang, Diego Altomare, Ying Shao, Jianguo Liu, Perry J. Blackshear, Susan M. Lessner, E. Angela Murphy, Hong Wang, Xiaofeng Yang, Daping Fan   +12 more
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, Volume 19, Issue 11, Page 3060-3078, November 2025.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Tristetraprolin mediates anti-inflammatory effect of carbon monoxide against DSS-induced colitis.

PLoS ONE, 2014
Endogenous carbon monoxide (CO) exerts anti-inflammatory effects. Tristetraprolin (TTP) is known to destabilize pro-inflammatory transcripts. Here we found that exogenous CO enhanced the decay of TNF-α mRNA and suppressed TNF-α expression in LPS ...
Yeonsoo Joe, Md Jamal Uddin, Min Zheng, Hyo Jeong Kim, Yingqing Chen, Nal Ae Yoon, Gyeong Jae Cho, Jeong Woo Park, Hun Taeg Chung   +8 more
doaj   +1 more source

The E3 ubiquitin ligase, RNF219, suppresses CNOT6L expression to exhibit antiproliferative activity

FEBS Open Bio, Volume 15, Issue 11, Page 1874-1885, November 2025.
We identified RNF219 as a CCR4‐NOT complex‐interacting E3 ubiquitin ligase that targets the CCR4‐NOT subunit CNOT6L for ubiquitination. RNF219 directly binds to the DUF3819 domain of CNOT1 through its putative α‐helix spanning amino acids 521–542. Our findings also suggest that antiproliferative activity of RNF219 is at least partially mediated by ...
Shou Soeda, Melissa Montrose, Akinori Takahashi, Risa Ishida, Sandrine Burriel, Nao Ohmine, Tohru Natsume, Shungo Adachi, Minsoo Kim, Tadashi Yamamoto   +9 more
wiley   +1 more source

The Potential Relationship Between Low Back Pain and Depression: A Comprehensive Review

Brain and Behavior, Volume 15, Issue 11, November 2025.
This work reveals bidirectional neurobiological links between low back pain (LBP) and depression through shared stress pathways. Chronic LBP triggers depression via HPA axis dysregulation and neuroinflammation, whereas depressive states amplify pain sensitivity through neural plasticity changes, establishing a self‐perpetuating comorbidity cycle ...
Li Cao, Biao Deng, Xiaole Wang, Ting Fang, KuyikAbasi Nsima Umoh, Lang Liu, Jiaming Qian, Fushui Liu   +7 more
wiley   +1 more source

GLA-3 Mediates Stress Response in Caenorhabditis elegans Germ Cells: A key role of the Tristetraprolin (TTP) Family

bioRxiv
Tristetraprolin or TTP is an RNA-binding protein that possesses two CCCH-like zinc-finger domains that bind AU-rich elements to promote their degradation. One of its targets is the mRNA of tumor necrosis factor alpha (TNF-α). When TTP is absence, the TNF-
L. S. Salinas, Ángel Armando Dámazo-Hernández, E. Morales-Oliva, Laura I Láscarez-Lagunas, R. E. Navarro   +4 more
semanticscholar   +1 more source

Ellagic Acid and Its Nanoparticles Mitigate Atherosclerosis by Elevating Low‐Density Lipoprotein Receptor Levels Through Targeting of the Epidermal Growth Factor Receptor

FASEB BioAdvances, Volume 7, Issue 11, November 2025.
Ellagic acid and its nano‐particles increase LDLR levels through targeting the EGFR. ABSTRACT Atherosclerosis is a chronic vascular disease characterized by the accumulation of cholesterol‐rich lipids within the intima of large and medium‐sized arteries.
Guo‐Tao Li, Li‐Tian Wang, Huai‐Liu Yin, Shuang‐Qing Zhao, Jun Sheng, Ye‐Wei Huang, Xuan‐Jun Wang   +6 more
wiley   +1 more source

Low Tristetraprolin Expression Is Associated with Lethal Prostate Cancer [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2019
Abstract Background: Inflammation is linked to prostate cancer progression and is mediated by NF-κB. Tristetraprolin is a key node of NF-κB activation and we investigated its biological and prognostic role in lethal prostate cancer. Methods:
Travis Gerke, Himisha Beltran, Xiaodong Wang, Gwo-Shu Mary Lee, Andrea Sboner, R. Jeffrey Karnes, Eric A. Klein, Elai Davicioni, Kasra Yousefi, Ashley E. Ross, Daniela Börnigen, Curtis Huttenhower, Lorelei A. Mucci, Bruce J. Trock, Christopher J. Sweeney   +14 more
openaire   +2 more sources

Metabolite to Modifier: Lactate and Lactylation in the Evolution of Tumors

MedComm, Volume 6, Issue 10, October 2025.
Tumor cells produce a significant amount of lactate due to the Warburg effect, leading to an increase in extracellular lactate, which inhibits the function of immune cells. Concurrently, the intracellular lactate accumulation results in enhanced lactylation of proteins, predominantly histones, thereby promoting the initiation and progression of cancer.
Long Zhao, Haoyue Cui, Yutong Li, Yingjiang Ye, Zhanlong Shen   +4 more
wiley   +1 more source

Resveratrol attenuates inflammation through tristetraprolin expression in human hepatocytes

Journal of Advanced Biotechnology and Experimental Therapeutics, 2018
Resveratrol (Resv), a polyphenolic compound have the anti-inflammatory and antioxidant effects. Tristetraprolin (TTP) destabilizes mRNAs of pro-inflammatory cytokines. However, it was not clear how Resv exerts anti-inflammatory effects on hepatocytes. In
Akhi Moni; Asif Iqbal; Md Jamal Uddin
doaj   +1 more source