Results 101 to 110 of about 3,877 (200)

Discovery of RNA‐Targeting Small Molecules: Challenges and Future Directions

MedComm, Volume 6, Issue 9, September 2025.
This review explores challenges and future directions in discovering RNA‐targeting small molecules, from analyzing RNA structures and computational design to experimental workflows. It discusses mechanistic strategies like splicing modulation and RNA degradation, alongside advanced tools (deep learning, docking, and validation) to accelerate drug ...
Zhengguo Cai, Hongli Ma, Fengcan Ye, Dingwei Lei, Zhenfeng Deng, Yongge Li, Ruichu Gu, Han Wen   +7 more
wiley   +1 more source

Advances and Deep Insights Into Lactylation: Essential Roles in Cellular Regulation and Disease Association

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT Proteins exert biological functions not only depending on abundance but also on regulation. Lactylation is an important novel post‐translational modification (PTM) that can affect protein structure and function, playing a crucial role in signal transduction, gene expression and cellular metabolism.
Tong Pan, Can‐can Du, Ying‐jian Zhang, Zhen‐long Liu   +3 more
wiley   +1 more source

PROPOSED MECHANISM OF ERLOTINIB-INDUCED RASH FORMATION IN RATS BASED ON THE SKIN EXPRESSION OF CINC1 AND TTP mRNAs

Jurnal Kedokteran Diponegoro
Background: Erlotinib's effect on the skin is greatly recognized to cause rashes. To treat the rashes effectively, it is necessary to understand the mechanism of rashes formation induced by the drug.
Iqbal Julian, Takuya Iwamoto
doaj   +1 more source

Tristetraprolin protects against osteoarthritis by restraining chondrocyte mitochondrial DNA release through post-transcriptional regulation.

Journal of Orthopaedic Translation
Background and objective Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation and chronic inflammation. Tristetraprolin (TTP) is an RNA-binding protein with anti-inflammatory properties, but its role in OA remains ...
Hong Huang, Jianmao Chen, Yingshi Zhan, Song Xue, Pengcheng Hu, Mingze Tang, Shiqian Huang, Yang Zhao, Cuixi Wu, Muhui Zeng, Hao Yang, Ze Chen, Zhaohua Zhu, Wende Xiao, Weiyu Han, C. Ding, Yan Zhang, G. Ruan   +17 more
semanticscholar   +1 more source

MK2 deficiency decreases mortality in male mice during the inflammatory phase after myocardial infarction

Physiological Reports, Volume 13, Issue 18, September 2025.
Abstract Altering inflammation can impact the recovering heart's structure and function following myocardial infarction (MI). MAP kinase‐activated protein kinase 2 (MK2) regulates the stability of several pro‐inflammatory cytokines. Hence, this study was to determine if MK2 deficiency impaired the inflammatory phase of post‐MI wound repair.
Joëlle Trépanier, Sherin A. Nawaito, Pramod Sahadevan, Fatiha Sahmi, Natacha Duquette, Danielle Gélinas, Marc‐Antoine Gillis, Yanfen Shi, Cynthia Torok, Marie‐Élaine Clavet‐Lanthier, Matthias Gaestel, Martin G. Sirois, Jean‐Claude Tardif, Bruce G. Allen   +13 more
wiley   +1 more source

ZFP36L1 negatively regulates autophagy and contributes to suppressing murine norovirus replication

Frontiers in Virology
Norovirus is a major cause of acute gastroenteritis worldwide, particularly in young children, and represents a significant public health concern. ZFP36L1, an RNA-binding protein, has demonstrated antiviral effects against several viruses, but its role ...
Malabika Bhowmik, Tooba Momin, Abiageal Newell, Mychaela Janzow, Neeraj Singh, Amit Singh, Mahmoud Darweesh, Mahmoud Darweesh, Mrigendra Rajput   +8 more
doaj   +1 more source

Increased Stability of Tristetraprolin mRNA Supports Bone Health and Decreases Frailty During Aging.

Aging and Disease
Age-related chronic low-grade inflammation contributes to both frailty and bone loss. One of the key regulators of inflammatory signaling that declines with age is tristetraprolin (TTP), an RNA-binding protein that promotes degradation of pro ...
Ramkumar Thiyagarajan, Lixia Zhang, Leticia Andrea Rojas Cortez, K. Kwack, V. Maglaras, N. Yellapu, Yukitomo Arao, K. Seldeen, Perry J. Blackshear, Bruce R Troen, K. L. Kirkwood   +10 more
semanticscholar   +1 more source

Evidence for OTUD-6B participation in B lymphocytes cell cycle after cytokine stimulation.

PLoS ONE, 2011
Deubiquitinating enzymes (DUBs) are important regulators of cell proliferation. Here we identified a functional deubiquitinating enzyme, ovarian tumor domain-containing 6B (OTUD-6B).
Zhongping Xu, Yufang Zheng, Yufei Zhu, Xiangyin Kong, Landian Hu   +4 more
doaj   +1 more source

Histone Deacetylase Inhibitors Activate Tristetraprolin Expression through Induction of Early Growth Response Protein 1 (EGR1) in Colorectal Cancer Cells

Biomolecules, 2015
The RNA-binding protein tristetraprolin (TTP) promotes rapid decay of mRNAs bearing 3' UTR AU-rich elements (ARE). In many cancer types, loss of TTP expression is observed allowing for stabilization of ARE-mRNAs and their pathologic overexpression.
Cyril Sobolewski, Sandhya Sanduja, Fernando F. Blanco, Liangyan Hu, Dan A. Dixon   +4 more
doaj   +1 more source

RNA binding proteins in the control of autoimmune diseases

Immunological Medicine, 2019
Autoimmune disease is induced by the breakdown of immune tolerance to self-antigens. This is brought about by an imbalance between the activation and the repression of immune responses.
Masanori Yoshinaga, Osamu Takeuchi
doaj   +1 more source